Antibacterial hydrogel

A hydrogel and glycidyl ester technology, applied in the fields of medical science and prosthesis, can solve the problems of poor swelling performance, and achieve the effects of good swelling performance, long antibacterial time and good hydrophilicity

Active Publication Date: 2020-02-11
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the scaffold formed by polyethylene glycol modified polyester has no cross-linking to form a network structure, and the swelling performance is poor, which cannot meet the requirements.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (a) Preparation of unsaturated polyester

[0024] 2g (0.001mol) polyethylene glycol monomethyl ether (CAS: 9004-74-4) with a molecular weight of 2000, 2g (0.02mol) succinic anhydride, 1.43g (0.01mol) octyl glycidyl ether, 2.28g Add (0.02mol) glycidyl methacrylate and 43.8mg (0.2mmol) zinc acetate to 10mL DMF, heat up to 100°C for ring-opening polymerization for 10h under nitrogen protection, cool down to room temperature, and add cold ether to precipitate.

[0025] The infrared spectrum of the unsaturated polyester obtained above was measured by Shimadzu FTIR-8100 infrared spectrometer. The detection found that its IR(v -1 , KBr) are 3224, 2712, 1999, 1761, 1609, 1207, 1189, 971, 652cm -1 . The absorption peak at 3224 corresponds to the C-H stretching vibration peak on methacrylate, 2712cm -1 Corresponding to saturated C-H stretching vibration peak, 1761cm -1 Corresponding to the stretching vibration peak of the carbonyl group in the ester bond, 1609cm -1 Correspo...

Embodiment 2

[0049] (a) Preparation of unsaturated polyester

[0050] 2g (0.001mol) polyethylene glycol monomethyl ether with a molecular weight of 2000, 3g (0.03mol) succinic anhydride, 3.72g (0.02mol) octyl glycidyl ether, 1.42g (0.01mol) glycidyl methacrylate Esters and 287mg (0.5mmol) of bis(triphenylphosphoryl)ammonium chloride were added to 20mL of DMF, heated to 90°C for ring-opening polymerization for 8h under nitrogen protection, cooled to room temperature, added to cold ether to precipitate.

[0051] The infrared spectrum of the unsaturated polyester obtained above was measured by Shimadzu FTIR-8100 infrared spectrometer. The detection found that its IR(v -1 , KBr) are 3159, 2882, 1922, 1879, 1593, 1167, 1058, 936, 616cm -1 . The absorption peak at 3159 corresponds to the C-H stretching vibration peak on methacrylate, 2882cm -1 Corresponding to saturated C-H stretching vibration peak, 1879cm -1 Corresponding to the stretching vibration peak of the carbonyl group in the ester...

Embodiment 3

[0068] (a) Preparation of unsaturated polyester

[0069] 2g (0.001mol) polyethylene glycol monomethyl ether with a molecular weight of 2000, 3g (0.03mol) succinic anhydride, 1.863g (0.01mol) octyl glycidyl ether, 2.84g (0.02mol) glycidyl methacrylate Esters, 57.4mg of bis(triphenylphosphoryl)ammonium chloride (0.1mmol) and 65.7mg (0.3mmol) of zinc acetate were added to 15mL of DMF, heated to 85°C for 6h under nitrogen protection, cooled to room temperature, added Precipitated from ether.

[0070] The infrared spectrum of the unsaturated polyester obtained above was measured by Shimadzu FTIR-8100 infrared spectrometer. The detection found that its IR(v -1 , KBr) is 3291, 2822, 1946, 1827, 1644, 1197, 1100, 957, 673cm -1 . The absorption peak at 3291 corresponds to the C-H stretching vibration peak on methacrylate, 2822cm -1 Corresponding to saturated C-H stretching vibration peak, 1827cm -1 Corresponding to the stretching vibration peak of the carbonyl group in the ester ...

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Abstract

The invention relates to antibacterial hydrogel. The antibacterial hydrogel consists of unsaturated polyester, dimethyl diallyl ammonium chloride, di(ethylene glycol) ethyl ether acrylate and photoinitiator, wherein the weight of the dimethyl diallyl ammonium chlorid is 1 time to 2 times of the weight of the unsaturated polyester, the weight of the di(ethylene glycol) ethyl ether acrylate is 2 times to 4 times of the weight of the unsaturated polyester, and the weight of the photoinitiator is 0.1 time to 0.5 time of the weight of the unsaturated polyester. The unsaturated polyester is initiated by methoxypolyethylene glycols, and is obtained by performing ring-opening polymerization on succinic anhydride, ethylhexyl glycidyl ether and glycidyl methacrylate. The antibacterial hydrogel disclosed by the invention is high in hydrophilicity and antibacterial performance, and long in antibacterial time.

Description

technical field [0001] The present invention relates to prosthetic materials characterized by their functional or physical properties, and in particular to polymeric hydrogels with antibacterial properties. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network and can retain a certain amount of water. It has the characteristics of viscoelasticity, hydrophilicity, porosity, and biocompatibility. It can be used in drug delivery, wound dressing, tissue repair, and cell culture. and implanted materials. Among them, antibacterial hydrogels have potential application prospects in the fields of health, medical devices, food industry, and personal hygiene. [0003] Currently, there are two types of preparation methods for antibacterial hydrogels. The first is to compound antibacterial agents and hydrogels, for example, mixing nano-silver with antibacterial activity or antibiotics with hydrogels. For example, Chinese patent (CN108339152A) re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/01C08F226/04C08F220/28C08G63/676C08G63/78A61L27/52A61L27/54A61L27/56A61L27/16
CPCC08F283/01C08G63/676C08G63/78A61L27/52A61L27/54A61L27/56A61L27/16C08F226/04
Inventor 吴旭屠以诺李想陈旭源
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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