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Antioxidant acne-removing repair essence and preparation method thereof

An anti-oxidation and essence technology, applied in the field of anti-acne repair essence and its preparation, in the field of anti-oxidation, can solve the problems of inability to dissolve and disperse, difficult for skin absorption and utilization, easy recrystallization and precipitation of cannabidiol, etc., and achieves the effect of moisturizing and moisturizing Good, increase transdermal absorption effect and bioavailability, clear and transparent appearance

Inactive Publication Date: 2020-02-21
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since cannabidiol is a fat-soluble compound and insoluble in water, it cannot be dissolved and dispersed when directly added to cosmetics, and it is difficult to be absorbed and utilized by the skin
Most of the essence is deionized water. Even if cannabidiol is dissolved by a solubilizer, it is easy to re-crystallize and separate out after adding a large amount of deionized water.

Method used

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  • Antioxidant acne-removing repair essence and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0037] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 300 mg of phospholipids and 100 mg of cholesterol and add them to ethanol, heat and stir to dissolve them fully to obtain an organic phase.

[0038] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 50 ° C and the vacuum degree is 0.1 MPa.

[0039] ③Hydration: Slowly add 20ml of 0.02mol / L phosphate buffer (pH 8.0) into the phospholipid film container, and continue rotary steaming for 3 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0040]④ Homogenization: inject the suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 40MPa, after homog...

Embodiment 2

[0046] (1) Preparation of cannabidiol nanoliposomes, the steps are as follows:

[0047] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 200 mg of phospholipids and 50 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.

[0048] ② Film production: Evaporate the organic phase obtained in step ① to remove the solvent on a rotary evaporator, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.2 MPa.

[0049] ③Hydration: Slowly add 15ml of 0.01mol / L phosphate buffer (pH7.0) into the phospholipid film container, and continue rotary steaming for 2 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0050] ④ Homogenization: Inject the above suspension into a high-pressure homogenizer for 2 times for homogenization, the homogenization pressure is 20MPa, after homogenizatio...

Embodiment 3

[0056] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0057] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 100 mg of phospholipid and 20 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain the organic phase.

[0058] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.1 MPa.

[0059] ③Hydration: Slowly add 10ml of 0.01mol / L phosphate buffer (pH6.5) into the phospholipid film container, and continue rotary steaming for 1 hour to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0060] ④ Homogenization: inject the above suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 30MPa, after homoge...

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Abstract

The invention discloses an antioxidant acne-removing repair essence and a preparation method thereof. The essence contains a plurality of plant extract essences, wherein cannabidiol (CBD) of a hemp extract has good effects of resisting bacteria, diminishing inflammation, removing acnes, relieving, resisting oxidation and the like. However, the CBD is insoluble in water, so that the application field and the bioavailability of the CBD are limited. According to the invention, the fat-soluble CBD is prepared into the nanoscale cannabidiol liposome, so that the water solubility and stability of the CBD are improved, the transdermal absorption effect of the CBD is promoted, the CBD can quickly and effectively penetrate through the surface layer of the skin, directly reach the deep layer of theskin and be slowly released, and the effect of the CBD is more lasting. The essence disclosed by the invention does not contain hormones, artificial pigments, essences and other components, is safe and mild in formula, and has multiple beautifying and skin-care effects of resisting oxidation, removing acnes, relieving, resisting bacteria, diminishing inflammation, efficiently moisturizing, smoothing fine lines and the like.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to an anti-oxidation, acne-removing and repairing essence lotion and a preparation method thereof. Background technique [0002] Essence is not a new type of product, but a dosage form of essence, which is rich in nutrients. Essence is to make up for the lack of efficacy of traditional skin care products. In other words, essence is positioned as a value-added cosmetic, at least highlighting some Functions, such as whitening, sun protection, anti-aging, repairing, etc. As people pay more and more attention to the safety of functional ingredients in cosmetics, plant extracts are popular as active ingredients added to cosmetics. [0003] Due to the important pharmacological and physiological activities of its active component cannabinoids, cannabis has been paid more and more attention by the world. So far, more than 100 plant-derived cannabinoids have been isolated. Ca...

Claims

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Application Information

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IPC IPC(8): A61K8/9794A61K8/14A61K8/34A61K8/365A61K8/44A61K8/60A61K8/63A61K8/65A61K8/67A61K8/68A61K8/73A61K8/92A61K8/9771A61K8/9789A61P17/10A61Q17/00A61Q19/08A61Q19/00
CPCA61K8/14A61K8/345A61K8/347A61K8/365A61K8/44A61K8/60A61K8/63A61K8/65A61K8/673A61K8/68A61K8/73A61K8/735A61K8/922A61K8/9771A61K8/9789A61K8/9794A61K2800/56A61P17/10A61Q17/005A61Q19/00A61Q19/08
Inventor 王钲霖刘胜贵薛红芬付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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