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Antibacterial self-repairing hydrogel and preparation method thereof

A self-healing and hydrogel technology, which is applied in the fields of polymer materials, tissue engineering, and biomedicine, can solve problems such as self-healing and antibacterial functions, and achieve high healing efficiency, short reaction cycle, and good antibacterial properties performance effect

Pending Publication Date: 2020-02-28
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although bacterial cellulose has many excellent properties, it does not have self-healing function and does not have antibacterial function. Through the introduction of functional components, the development of bacterial cellulose-based functional materials can fully tap its application potential

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Synthesis of choline-isoleucine ionic liquid: mix isoleucine and deionized water with a molar ratio of 1:30, and choline and deionized water with a molar ratio of 1:30 Then slowly add it dropwise into the amino acid solution, the molar ratio of choline and amino acid is 1:1.05, place it in an ice-water bath for 48 hours, and use a rotary evaporator after the reaction is completed, carry out rotary evaporation at 55°C and 110r / min to obtain The concentrated choline-amino acid ionic liquid is stored for future use.

[0026] (2) Preparation of vinylcholine-isoleucine ionic liquid monomer: AAc, EDC, and N-hydroxysuccinimide were uniformly dissolved in the desiccated In ionized water, react for 2 hours, add choline-isoleucine ionic liquid with a mass fraction of 11%, and then add EDC every 6 hours for a total of 5 times. After the EDC is added, use a rotary evaporator under the same conditions Next, the reaction solution was subjected to secondary rotary evaporation to ...

Embodiment 2

[0031](1) Synthesis of choline-phenylalanine ionic liquid: phenylalanine and deionized water are mixed uniformly at a molar ratio of 1:30, and choline and deionized water are mixed uniformly at a molar ratio of 1:30 After that, it was slowly added dropwise into the amino acid solution, the molar ratio of choline and amino acid was 1:1, placed in an ice-water bath for 48 hours, and after the reaction was completed, it was carried out with a rotary evaporator at 65°C and 140r / min to obtain The concentrated choline-amino acid ionic liquid is stored for future use.

[0032] (2) Preparation of vinylcholine-phenylalanine ionic liquid monomer: AAc, EDC, and N-hydroxysuccinimide are respectively dissolved in a mass fraction of 6%, 16%, and 1.5%. React in ionized water for 1 hour, add choline-isoleucine ionic liquid with a mass fraction of 11%, and then add EDC every 5 hours for a total of 5 times. After adding EDC, use a rotary evaporator under the same conditions Next, the reaction ...

Embodiment 3

[0037] (1) Synthesis of choline-serine ionic liquid: mix serine and deionized water in a molar ratio of 1:25, and then slowly add choline and deionized water to the amino acid after mixing evenly in a molar ratio of 1:25 In the solution, the molar ratio of choline and amino acid is 1: 1.03, and it is placed in an ice-water bath for 48 hours. After the reaction is completed, use a rotary evaporator to carry out rotary evaporation at 60°C and 130r / min to obtain concentrated choline- Amino acid ionic liquid, kept for future use.

[0038] (2) Preparation of vinylcholine-serine ionic liquid monomer: AAc, EDC, and N-hydroxysuccinimide were uniformly dissolved in deionized water with mass fractions of 6%, 18%, and 1.9%, respectively, React for 2 hours, add choline-serine ionic liquid with a mass fraction of 20%, and then add EDC every 5 hours for a total of 5 times. Rotary evaporation, the concentrated VILs were obtained and stored for future use.

[0039] (3) Preparation and purif...

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Abstract

The invention relates to an antibacterial self-repairing hydrogel and a preparation method thereof. According to the invention, the hydrogel is endowed with a self-repairing function by a physical crosslinking method based on a hydrophobic effect; the hydrogel is endowed with antibacterial properties and conductivity through introduction of choline-amino acid ionic liquid (VILs); and the tensile property and toughness of the hydrogel are enhanced by bacterial cellulose (BC) with good biocompatibility. The preparation method of the hydrogel comprises the following steps: (1) synthesis of choline-amino acid ionic liquid; (2) preparation of a vinyl choline-amino acid ionic liquid monomer (VILs); (3) purification and hydrolysis of bacterial cellulose; and (4) forming of the polycholine-amino acid ionic liquid self-repairing hydrogel. The hydrogel disclosed by the invention is high in self-healing efficiency, has good antibacterial property, mechanical property, conductivity and biocompatibility, and is applicable to the fields of biology, medical treatment and tissue engineering.

Description

technical field [0001] The invention relates to the technical fields of polymer materials, biomedicine and tissue engineering, in particular to a hydrogel with antibacterial properties and self-repairing and a preparation method thereof. Background technique [0002] Because the hydrogel is filled with a large amount of water in its polymer network, the whole material has a fluid property, which is very similar to the body tissue filled with a large amount of aqueous liquid, and is widely used in the field of biomedicine. However, the existing medical gel materials are prone to micro-nano cracks during use, which will hinder the diffusion and penetration of drug molecules, resulting in interruption of treatment. As a new type of biomedical smart material, self-healing hydrogel is of great significance in solving the problem of flexible biomaterial damage repair and realizing the intelligence and efficiency of biomaterials. [0003] Self-healing materials generally exist in ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F251/02C08F226/02C08F220/18C08F220/56
CPCC08F251/02C08J3/075C08F226/02C08F220/56
Inventor 贺晓凌孙晓倩宋浩德王帅贺婷婷魏东盛
Owner TIANJIN POLYTECHNIC UNIV
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