A photoactive polypyridine ruthenium complex and its application

A technology of ruthenium polybipyridine and ruthenium bipyridine is applied in the field of ruthenium polybipyridine complexes, which can solve the problems of few anti-tumor studies and the like
CN110857310BActive Publication Date: 2021-05-28NANJING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING UNIV
Publication Date
2021-05-28

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Abstract

The present invention is based on [Ru(bpy) 3 ] 2+ Ru(II) complexes with different conjugation systems were synthesized by modifying the ligands of the polypyridine ruthenium complexes as the core, and the ligand conjugation structure was studied for the generation of singlet oxygen in such complexes. rate impact. In the photodynamic therapy of tumors, the complexes of the present invention have the maximum singlet oxygen production rate, and not only have higher phototoxicity under light, but also increase the uptake of the complexes by cells. The increase in the amount leads to the possible chemical anti-cancer effect after it enters the cells, further improving its anti-tumor activity.
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Description

technical field

[0001] The invention belongs to the field of metal complexes, in particular to a photoactive polypyridine ruthenium complex and its application Background technique

[0002] Cancer has become the second largest killer of human health and seriously endangers human life. The United Nations Cancer Agency recently pointed out that by 2030, more than 13 million people will die of cancer every year. Chemotherapy drugs, biological agents and targeted drugs are currently the most commonly used anticancer drugs. Among them, chemotherapy drugs are the main means of treating cancer. Among chemotherapy drugs, the clinical utilization rate of platinum drugs exceeds 50%. The anti-cancer mechanism of platinum-based drugs is usually combined with DNA, by changing the spatial structure of DNA, inhibiting DNA replication and transcription, to prevent the proliferation of tumor cells, but tumor cells are resistant to their own or acquired Drug resistance limits the clinical ...

Claims

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