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Glucosamine hyaluronate and application thereof

A technology of hyaluronate and glucosamine, which is applied in the field of glucosamine hyaluronate and its application, to achieve good therapeutic effect, safe application and high purity

Active Publication Date: 2020-04-03
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no corresponding research on the structural modification of sodium hyaluronate

Method used

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  • Glucosamine hyaluronate and application thereof
  • Glucosamine hyaluronate and application thereof
  • Glucosamine hyaluronate and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Weigh 5 g of hyaluronic acid with a molecular weight of 100,000 and 5 g of glucosamine hydrochloride, dissolve them in water, dialyze in a dialysis bag with a molecular weight cut-off of 2000 Da for 1 day, concentrate by rotary evaporation, and freeze-dry to obtain glucosamine hyaluronate.

Embodiment 2

[0032] The difference from Example 1 is:

[0033] Weigh 3 g of hyaluronic acid with a molecular weight of 500,000 and 5 g of glucosamine hydrochloride, dissolve them in water, dialyze in a dialysis bag with a molecular weight cut-off of 500 Da for 3 days, concentrate by rotary evaporation, precipitate with ethanol, suction filter, and dry at 60 degrees Celsius After 8 hours, glucosamine hyaluronate was obtained.

Embodiment 3

[0035] The difference from Example 1 is:

[0036] Weigh 2g of hyaluronic acid with a molecular weight of 50,000 and 5g of glucosamine hydrochloride, dissolve them in water, use ion exchange, remove metal ions through a cation exchanger, and then enter an anion exchanger to remove anions to obtain glucosamine hyaluronic acid saline solution, spray-dried to obtain glucosamine hyaluronate.

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PUM

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Abstract

The invention relates to the industries of functional food, cosmetics and medicine, and in particular, relates to glucosamine hyaluronate and an application thereof. The structural formula of the glucosamine hyaluronate is represented by a formula (1), and the average polymerization degree n is 10-1000. The prepared glucosamine hyaluronate has a good treatment effect on osteoarthritis model rats in an articular cavity injection mode, and can be used for but not limited to the field of daily chemicals especially moisture absorption and preservation agents of cosmetics, wrinkle removal filling injection for beauty, anti-fatigue eye drops and related joint treatment or auxiliary health care.

Description

technical field [0001] The invention relates to functional food, cosmetics and pharmaceutical industries, in particular to glucosamine hyaluronate and its application. Background technique [0002] Glucosamine compounds are a class of specific drugs for the treatment of osteoarthritis, and are also important components necessary for the synthesis of amino polysaccharides in the human articular cartilage matrix. At present, the reported glucosamine compounds are almost all in the form of glucosamine inorganic acid salts, mainly including its hydrochloride, sulfate, and compound salts containing metal elements such as magnesium and calcium. Among them, glucosamine hydrochloride is mainly obtained by degrading chitin under hydrochloric acid and high temperature conditions; the preparation of glucosamine sulfate is obtained by degrading chitin through sulfuric acid, and one method is through glucosamine hydrochloride obtained by salt substitution. The preparation of various gl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K8/73A61K9/00A61K47/36A61Q19/00
CPCC08B37/0072A61K8/735A61K47/36A61K9/0019A61Q19/00
Inventor 郭占勇谭文强王刚董方李青
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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