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Ecological food for simulating fecal transplantation, and production method and application thereof

A fecal transplantation and ecological technology, which is applied to the field of ecological food simulating fecal transplantation and its preparation, can solve the problems of the efficacy and safety of fecal transplantation, insufficient medical evidence, and infection of patients with drug-resistant bacteria.

Inactive Publication Date: 2020-04-17
天津创源生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the efficacy of fecal microbiota transplantation and its long-term safety and medical evidence are not sufficient, and there are occasional reports of drug-resistant bacterial infections in patients caused by fecal microbiota transplantation

Method used

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  • Ecological food for simulating fecal transplantation, and production method and application thereof
  • Ecological food for simulating fecal transplantation, and production method and application thereof
  • Ecological food for simulating fecal transplantation, and production method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Example 1: A method for preparing ecological food using a bionic technology that simulates the characteristics of each stage of the human digestive process in vitro

[0094] Proceed as follows:

[0095] 1. Simulate the characteristics of the upper digestive tract to process food (mouth-duodenum part)

[0096] (1) Simulated oral grinding, stirring and salivary amylase enzymatic hydrolysis: wash soybeans, tartary buckwheat, and hemp seeds and dry them in an oven at 60°C for 6 hours, and grind them to a size above 60 mesh to obtain soybean powder and tartary buckwheat powder 1. Hemp seed powder, mix soybean powder, tartary buckwheat powder, and hemp seed powder in a weight ratio of 4.5:3:2.5 to obtain a mixed raw material powder, mix the raw material powder and water in a mass-volume ratio of 1:1.8, After heating, add amylase for enzymolysis, the amount of amylase added is 30U / g, the enzymolysis condition is 40°C, 60min, keep stirring during the process;

[0097] (2) Sim...

Embodiment 2

[0109] Example 2: A method for preparing ecological food using a bionic technology that simulates the characteristics of each stage of the human digestive process in vitro

[0110] Proceed as follows:

[0111] 1. Simulate the characteristics of the upper digestive tract to process and digest food (mouth-duodenum part)

[0112] (1) Simulated oral grinding, stirring, and salivary amylase enzymatic hydrolysis: wash soybeans, red beans, white kidney beans, oats, tartary buckwheat, turmeric, Yu Liren, mulberry leaves, and hemp seeds and dry them in an oven at 60°C for 6 hours. Grind the powder to more than 60 meshes to obtain soybean powder, red bean powder, white kidney bean powder, oat powder, tartary buckwheat powder, turmeric powder, plum seed powder, mulberry leaf powder, and hemp seed powder, and mix them in equal weight ratios to obtain mixed raw material powder , mix the raw material powder and water at a ratio of 1:1.8, add amylase after heating for enzymolysis, the amoun...

Embodiment 3

[0125] The preparation of ecological food under the different fermentation parameters of embodiment 3

[0126] (1) Different ratios of bionic digestion raw materials

[0127] The raw materials soybean, tartary buckwheat and hemp seed are divided into 5 groups with different weight ratios, and the following groups are set:

[0128] Combination 1: 3: 3: 4

[0129] Combination two: 3.5: 2: 4.5

[0130] Combination three: 4: 2.5: 3.5

[0131] Combination four: 4.5: 3: 2.5

[0132] Combination five: 5: 3.5: 1.5

[0133] According to the above five groups of different proportions, the following ecological foods are prepared, and the steps are as follows:

[0134] 1. Process the food by simulating the characteristics of the upper digestive tract: the steps are the same as (1)-(3) in step 1 of Example 1, the only difference is that the composition of the raw materials is according to the above five different combination ratios;

[0135] 2. Simulate the characteristics of the low...

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Abstract

The invention discloses an ecological food for simulating fecal transplantation, and a production method and an application thereof, and belongs to the field of probiotic fermentation and application.The production method of the ecological food comprises the following steps: mixing raw materials with water, sequentially adding single enzymes including amylase, pepsase and pancreatin in three stages, and performing enzymolysis; inoculating the raw materials with Bacillus subtilis and Bacillus coagulans after enzyme deactivation of the raw materials, performing aerobic fermentation, inoculatingwith Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus paracasei, Pediococcus acidilactici and Lactobacillus plantarum, performing airtight fermentation, finally inoculating with Bifidobacterium adolescentis, Bifidobacterium longum and Bifidobacterium animalis, performing strict anaerobic fermentation, and performing freeze-drying to obtain the product. Theecological food can simulate fecal transplantation therapy and relieve a series of health problems caused by intestinal flora imbalance. The ecological food can be directly eaten, does not need to beintroduced into the intestinal tract of a patient through a complex method, reduces the administration difficulty, and can be used as a supplement or partial replacement scheme of fecal transplantation therapy.

Description

technical field [0001] The invention belongs to the field of fermentation and application of probiotics, and in particular relates to an ecological food simulating feces transplantation and its preparation method and application. Background technique [0002] As an important participant in the normal operation of the human body, intestinal microorganisms form a complex micro-ecosystem in the intestinal tract. Through the interaction with each other and the human body, they maintain a state of dynamic balance for a long time, and participate in intestinal nutrition, immune , metabolism and barrier function and other physiological activities. When this micro-ecological system is broken, the human body will produce a series of health problems, such as inflammatory bowel disease, recurrent Clostridium difficile infection, irritable bowel syndrome, metabolic related diseases, etc. [0003] Fecal transplantation, also known as fecal flora transplantation, refers to the method of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L29/00A23L33/135A23L3/3571A23L11/00A23L7/104A23L25/00A23L11/50
CPCA23L33/00A23L29/06A23L29/065A23L33/135A23L3/3571A23L7/104A23L25/40A23V2002/00A23L11/50A23V2400/113A23V2400/165A23V2400/173A23V2400/175A23V2400/169A23V2400/413A23V2400/513A23V2400/515A23V2400/533A23V2200/32A23V2200/10A23V2250/124
Inventor 梁武张震韩雪梅沈发迪李树森
Owner 天津创源生物技术有限公司
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