High-strength self-healing hydrogel based on modified hyaluronic acid and preparation method thereof

Abstract

The invention discloses high-strength self-healing hydrogel based on modified hyaluronic acid and a preparation method of the high-strength self-healing hydrogel. The self-healing hydrogel is preparedfrom raw materials including maleic hydrazide hyaluronic acid and aldehyde hyaluronic acid. According to the invention, all-natural polymer hyaluronic acid is used as a matrix, so that the hydrogel has good biocompatibility; the hydrogel is endowed with good self-healing performance through multiple dynamic covalent bond combination of acylhydrazone bonds and disulfide bonds between the maleic hydrazide hyaluronic acid and the aldehyde hyaluronic acid; then, a photo-crosslinking mode is further adopted to carry out secondary crosslinking on the hydrogel, so that the hydrogel has excellent mechanical properties. The characteristics of disulfide bonds are utilized, a photoinitiator does not need to be additionally added in the photo-crosslinking process, so that the toxic damage of the photoinitiator to organisms is avoided, meanwhile, the characteristic of high click reaction speed of schiff is utilized, the hydrogel can be rapidly formed, and therefore, a gel solution is prevented from flowing in the organisms.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a high-strength self-healing hydrogel based on modified hyaluronic acid and a preparation method thereof. Background technique [0002] In the treatment of cancer patients, the prevention of postoperative recurrence is very important. The current conventional treatment methods include adjuvant chemotherapy, endocrine therapy and radiotherapy, etc., but some toxic reactions and systemic side effects can not be ignored. Since many types of tumor recurrence usually start locally, such as breast tumors, it has been proposed in recent years to introduce bioscaffold materials (such as hydrogels, biofilms, etc.) loaded with functional molecules into tumor sites to achieve in situ killing of tumor cells, Therapeutic strategies to suppress tumor recurrence. [0003] Hydrogel is an ideal tissue engineering repair material and has received extensive attention in the field of tum...

AI Technical Summary

Problems solved by technology

However, there are still some shortcomings in its application: first, in the complex in vivo environment, the hydrogel is easily affected by external stimuli, so it cannot function stably; second, the structural integrity of the hydrogel is easily damaged, and Partial fracture, which will affect the therapeutic effect and interfere with the repair of tissue space and the growth and differentiation of cells

However, the above-mentioned self-healing hydrogels are usually soft and brittle, and the mechanical strength and self-healing ability cannot meet the application requirements to a large extent, which makes them unable to be used for the replacement and repair of biological tissues under high loads, which limits their application. application

Moreover, the preparation process of the above self-healing hydrogel is complicated and expensive, which further limits its application.

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