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Drug loading system capable of loading anti-cancer drug, and preparation and application of drug loading system

An anti-cancer drug and drug-carrying technology, which is applied in drug delivery, anti-tumor drugs, drug combination, etc., can solve the problems of weak targeting performance and tissue cell damage, and achieve good biocompatibility, large pore volume, water-soluble good sex effect

Active Publication Date: 2020-05-01
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, it is necessary to provide a drug-carrying system loaded with anticancer drugs and its preparation and application to solve the problems caused by the weak targeting performance of anticancer drugs or drug-carrying systems containing anticancer drugs in the prior art during chemotherapy. The problem of damage to the normal body tissue cells of the patient

Method used

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  • Drug loading system capable of loading anti-cancer drug, and preparation and application of drug loading system
  • Drug loading system capable of loading anti-cancer drug, and preparation and application of drug loading system
  • Drug loading system capable of loading anti-cancer drug, and preparation and application of drug loading system

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Experimental program
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Effect test

Embodiment 1

[0050] The preparation of embodiment 1 mesoporous silica nanosphere MSN

[0051] Add 0.9614g CTATos and 0.14mLTEA into 50mL deionized water, heat to 60-80°C, and stir for 1h. TEOS (2-2.5 mL) was added and stirring continued for 2 h. After standing to cool to room temperature, the mesoporous silica nanospheres (MSN) were collected by centrifugation. Wash several times by centrifugation with absolute ethanol. The precipitate was dispersed in 100 mL of 0.6% wt ammonium nitrate ethanol solution, extracted at 60° C. for 24 h to remove the template. Centrifuge at 11500rpm, wash the precipitate alternately with water and absolute ethanol several times, repeat the extraction 3 times, and store the MSN in absolute ethanol.

Embodiment 2

[0052] Example 2 Preparation of a Mesoporous Silica Nanosphere MSN / Drug Nanoparticle

[0053] Get the RuDPNI dimethyl sulfoxide solution of 30mg / mL, add the MSN prepared by the method of Example 1, the mass ratio of the added MSN and the small molecule complex RuDPNI is 1:1, stir for 72h, centrifuge at 5000rpm for 3min, and then use 25mL of water was redispersed and then centrifuged to obtain drug-loaded silicon mesoporous nanoparticles (Ru-MSN).

Embodiment 3

[0054] Example 3 Preparation of a Mesoporous Silica Nanosphere MSN / Drug Nanoparticle

[0055] The difference from Example 2 is that the mass ratio of MSN added to the small molecule complex RuDPNI is 1.5:1.

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Abstract

The invention relates to the technical field of nanometer medicines, in particular to a drug loading system capable of loading an anti-cancer drug, and preparation and application of the drug loadingsystem. Drug loading particles consisting of micromolecule complexes and mesoporous silica nanospheres with good biocompatibility and a large specific surface area are adopted as an inner nuclear layer, and the outer surface of the inner nuclear layer is coated with a lipidosome layer containing a specific target protein and a liposome membrane. Since the lipidosome layer is blended by the specific target protein (which is expressed due to the blending and the construction of H1299.2 target peptide, e-GFP (enhanced green fluorescent protein) and MscL) and the liposome membrane, after the drugloading system enters an organism as an anti-cancer chemotherapy drug, the anti-cancer chemotherapy drug is not accumulated in normal tissues without target protein binding sites, and the drug loadingparticles and the lipidosome layer are combined on a tumor cell with a target position to realize fixed-point drug releasing. Since the specific target protein contains the e-GFP, the distribution ofthe specific target protein in the body can be measured through the measurement of a fluorescence value of the e-GFP so as to more accurately guide drug utilization during chemotherapy.

Description

technical field [0001] The present invention relates to the field of nanomedicine technology, in particular to a proteoliposome anti-tumor drug targeting carrier supported by mesoporous silica nanospheres and the coupling of the carrier with anti-tumor drugs, and the formed carrier Drug systems and their preparation and application. Background technique [0002] Cancer is considered by the World Health Organization to be the "No. 1 killer" of human beings in the 21st century. It seriously threatens the survival of human beings. It is difficult to diagnose and has a high mortality rate. The treatment of malignant tumors mainly adopts surgical resection, radiotherapy, immunotherapy and chemotherapy. . Cancer control has become a global health strategic priority. At present, China has become the world's largest cancer country, and cancer not only seriously threatens people's lives and health. Chemotherapy is still one of the main means of treating malignant tumors. Tradition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/42A61K47/04A61K45/00A61P35/00
CPCA61K9/0053A61K9/1271A61K45/00A61K47/02A61K47/42A61P35/00
Inventor 吴允昆肖方南陈方满张维彬
Owner FUJIAN NORMAL UNIV
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