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A method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product

A lubricating coating and interface bonding technology, applied in coatings, pharmaceutical formulations, catheters, etc., can solve the problem of low surface adhesion between lubricating substances and polymer materials, a wide variety of raw materials, organic solvents, human nerve stimulation or paralysis, etc. problems, to achieve the effect of long-term stable use, excellent hydrophilicity and lubricity, and excellent mechanical properties

Active Publication Date: 2021-07-30
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The surface coatings with good hydrophilicity and lubricity prepared by the above-mentioned various methods, but in some methods, the adhesion between the lubricating substance and the surface of the polymer material is small, and the lubricating substance is easy to fall off from the surface of the polymer material and loses the lubricating effect. Problem: Some methods have complex preparation process, various raw materials and use a large amount of organic solvents, which are difficult to completely remove in the later stage. The residue of organic solvents in the coating will become a potential hidden danger, which will cause negative effects such as nerve stimulation or paralysis to the human body. role problem

Method used

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  • A method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product
  • A method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product
  • A method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product

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Embodiment 1

[0033] A method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product of the present invention comprises the following steps:

[0034] (1) The medical catheter is ultrasonically cleaned and dried with acetone, ethanol, and water in sequence, and treated with oxygen plasma to introduce active groups such as hydroxyl and carboxyl.

[0035] (2) Soak the medical catheter treated in step (1) in the silane coupling agent solution for 6 hours at room temperature, so that condensation reaction occurs on the surface of the medical catheter, and the coupling agent molecules are grafted. The components of the silane coupling agent solution are: 1 wt% of silane coupling agent, 3 wt% of deionized water, and the rest is ethanol. After the silane coupling agent solution is mixed evenly, the pH of the solution is adjusted to a range of 3.5-5.5 with acetic acid, and the hydrolysis reaction is carried out.

[0036] (3) With ...

Embodiment 2

[0039] A method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product of the present invention comprises the following steps:

[0040] (1) The medical catheter is ultrasonically cleaned and dried with acetone, ethanol, and water in sequence, and treated with oxygen plasma to introduce active groups such as hydroxyl and carboxyl.

[0041] (2) Soak the medical catheter treated in step (1) in the silane coupling agent solution for 1 hour at room temperature, so that the surface of the medical catheter undergoes a condensation reaction, and the coupling agent molecules are grafted. The composition of the silane coupling agent solution is: 3wt% of silane coupling agent, 5wt% of deionized water, and the rest is ethanol. After the silane coupling agent solution is mixed evenly, the pH of the solution is adjusted to a range of 3.5-5.5 with acetic acid, and the hydrolysis reaction is carried out.

[0042] (3) With p...

Embodiment 3

[0045] A method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product of the present invention comprises the following steps:

[0046] (1) The medical catheter is ultrasonically cleaned and dried with acetone, ethanol, and water in sequence, and treated with oxygen plasma to introduce active groups such as hydroxyl and carboxyl.

[0047] (2) Soak the medical catheter treated in step (1) in the silane coupling agent solution for 3 hours at room temperature, so that condensation reaction occurs on the surface of the medical catheter, and the coupling agent molecules are grafted. The components of the silane coupling agent solution are: 5 wt% of silane coupling agent, 10 wt% of deionized water, and the rest is ethanol. After the silane coupling agent solution is mixed uniformly, the pH of the solution is adjusted to a range of 3.5-5.5 with acetic acid, and the hydrolysis reaction is carried out.

[0048] (3) W...

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Abstract

The invention discloses a method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of a polymer medical product, comprising the following steps: (1) oxygen plasma treatment on the surface of a polymer medical product; (2) grafting of coupling agent molecules ; (3) Configuration of lubricating coating solution; (4) Chemical crosslinking of lubricating coating on the surface of polymer medical products. The interfacially bonded hydrophilic lubricating coating prepared by the present invention has good biocompatibility, excellent hydrophilicity and lubricity, and at the same time is firmly combined with the surface interface of polymer medical products, and can be widely used in polymer medical products such as respiratory tract and digestive tract Lubrication of medical catheters such as , rectum, etc. can effectively protect the inner wall of the cavity and reduce the discomfort or pain of the patient during use.

Description

technical field [0001] The invention relates to the technical field of surface functionalization of medical polymer materials, in particular to a method for preparing a hydrophilic lubricating coating with strong interfacial bonding on the surface of polymer medical products. Background technique [0002] Polymer medical products such as medical catheters, drainage tubes, intubation tubes, etc. are mostly composed of hydrophobic polymers, resulting in a large frictional resistance between the outer wall of the polymer medical product and human tissue or mucous membrane of the cavity, and it is easy to cause tissue mucous membrane damage during the insertion process. Injury, leading to complications such as inflammation and ulcers (Parada G A, et al. Nature Communications 2016,7: 12028; Yu Y, et al. Advanced Materials 2018, 1807101). In order to improve the lubricity of polymer medical products, it is usually chosen to coat the surface with lubricating substances (Shaji S, et...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L29/14
CPCA61L29/085A61L29/14A61L2400/10A61L2420/02C08L51/08
Inventor 赵柏松徐家壮李妍蒲宋兴荣李忠明
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER