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Blood purification adsorbent and preparation method thereof and hemoperfutor

A blood purification and adsorbent technology, applied in chemical instruments and methods, inorganic chemistry, alkali metal compounds, etc., can solve the problems of decreased adsorption capacity and adsorption range, poor mechanical properties of activated carbon, vascular blockage, etc., and achieves pore size and distribution. Controllable, wide adsorption range, excellent mechanical properties

Pending Publication Date: 2020-05-05
苏州仝康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The earliest blood purification material used is activated carbon (the first generation product). Activated carbon has a rich porous structure and can absorb toxins in a wide range. However, the mechanical properties of activated carbon are poor, and particles will fall off during use, which can easily cause serious blood vessel blockage.
The improved second-generation blood purification adsorbent is polystyrene microspheres. Compared with the first-generation product activated carbon, the mechanical strength of the adsorbent is greatly improved, but the adsorption capacity and adsorption range are reduced.

Method used

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  • Blood purification adsorbent and preparation method thereof and hemoperfutor
  • Blood purification adsorbent and preparation method thereof and hemoperfutor
  • Blood purification adsorbent and preparation method thereof and hemoperfutor

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Experimental program
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Effect test

Embodiment 1

[0029] A blood purification adsorbent of the present embodiment, the blood purification adsorbent is a porous polyurethane airgel material, which is obtained by using MDI trimer and polyethylene glycol / polypropylene glycol as raw materials, through the sol-gel method, supercritical Obtained after drying with carbon dioxide. The blood purification adsorbent has the characteristics of excellent mechanical properties, controllable pore size and distribution, high specific surface area, large adsorption capacity and the like.

Embodiment 2

[0031] The preparation method of the blood purification adsorbent of embodiment 1, it comprises the following steps:

[0032] 1) Add 5L of acetone to tank A, then add 1 mol of MDI trimer into it, fully shake and dissolve to obtain the first solution;

[0033] 2) Add 5L of acetone to tank B, then add 1.5 mol of polyethylene glycol or polypropylene glycol into it, fully shake and dissolve to obtain the second solution; wherein, polyethylene glycol is polyethylene glycol 200, polyethylene glycol One of alcohol 400, polyethylene glycol 600, polyethylene glycol 800, polypropylene glycol is polypropylene glycol 400 or polypropylene glycol 1000;

[0034] 3) Mix the first solution and the second solution in tanks A and B, stir and dissolve them fully, add 5mL catalyst DBTDL to obtain the third solution;

[0035] 4) Pour the obtained third solution into the mold, let it stand at room temperature, gel after 12 hours, take it out after gel, soak and wash 4 times with acetone, and then d...

Embodiment 3

[0037] Carry out performance test to the porous polyurethane airgel that embodiment 2 makes

[0038] refer to figure 1 , is the pore size distribution diagram of the porous polyurethane airgel. It can be seen from the figure that the prepared porous polyurethane airgel block material has a wide range of pore size distribution, ranging from 2nm to 100nm.

[0039] refer to figure 2 , is the comparison result figure of the porous polyurethane airgel of embodiment 2 and the international similar products in the prior art for the removal effect of bacterial endotoxin in blood plasma, as can be seen from the figure, the porous polyurethane airgel of embodiment 2 The removal effect of the gel on bacterial endotoxin is significantly better than that of the other three existing products.

[0040] refer to image 3 , is the comparison result of the adsorption rate of cytokines between the porous polyurethane airgel of Example 2 and the international similar products (Cytosorb, Toray...

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Abstract

The invention discloses a blood purification adsorbent. The blood purification adsorbent is porous polyurethane aerogel. The invention also discloses a preparation method of the blood purification adsorbent, and the blood purification adsorbent is prepared by taking MDI trimer and polyethylene glycol / polypropylene glycol as raw materials through adoption of a sol-gel method and supercritical carbon dioxide drying. The invention also discloses a hemoperfutor. The porous polyurethane aerogel is used as an adsorbent in the hemoperfutor. The blood purification adsorbent provided by the invention adopts a porous polyurethane aerogel material, and has the advantages of excellent mechanical properties, controllable pore size and distribution, the high specific surface area, the large adsorption capacity and the like; and the adsorbent is wide in adsorption range, can adsorb bacterial endotoxin, tumor necrosis factors, interleukin 6 and other cytokines in blood plasma at the same time, and canbe used for treating endotoxemia, sepsis, cytokine storm and other diseases caused by severe infection.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a blood purification adsorbent, a preparation method thereof, and a hemoperfusion device. Background technique [0002] Blood purification refers to the technology of specifically or relatively specifically removing the pathogenic toxins in the patient's plasma. Blood purification therapy is to drain the patient's plasma out of the body, flow through a perfusion device loaded with adsorbent, and remove the virus-causing toxins from human plasma through the action of plasma and adsorbent. The sorbent is the core of the perfusion device, and the clearance rate of the target toxin in the plasma is a key indicator for evaluating the sorbent. At present, the adsorbents successfully used in clinical practice include polystyrene anion exchange resin for the treatment of liver failure, high specific surface area polystyrene microspheres for the treatment of renal failure, and polyvin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30
CPCB01J20/262B01J20/28047Y02C20/40
Inventor 郑飞周平刘路邢雪奎陈荣胜
Owner 苏州仝康医疗科技有限公司
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