Anti-allergic sulfated polysaccharide and preparation method and application thereof

Abstract

The invention relates to anti-allergic sulfated polysaccharide and a preparation method and application thereof. The anti-allergic sulfated polysaccharide uses sulfated polysaccharide as a raw material, is obtained by removing divalent metal ions from the raw material and has the characteristics of low molecular weight and high content of sulfuric acid groups, wherein the molecular weight of the anti-allergic sulfated polysaccharide is 600 Da-1000 Da, and the retention degree of the sulfuric acid groups relative to the raw material sulfated polysaccharide is more than or equal to 95% by mass.The method for preparing the anti-allergic sulfated polysaccharide is simple in production process and high in production efficiency, and the obtained anti-allergic sulfated polysaccharide is high inanti-allergic activity and very suitable for developing anti-allergic medicines or functional foods.

Description

technical field [0001] The invention relates to the field of biological preparations, in particular to an antiallergic sulfated polysaccharide and its preparation method and application. Background technique [0002] With the increasing number of people with food allergies, food allergic diseases have become an important public health problem. Studies have shown that about 8% of children in the United States have food allergies (Gupta et al., 2011); the proportion of food allergies in European populations is as high as 6% (Nwaru et al., 2014); food allergies in 1-year-old children in Australia The incidence rate reaches 11% (Peters et al., 2017). In my country, the prevalence of food allergy increased from 3.5% in 1999 to 7.7% in 2009 (Hu et al., 2010). However, the drugs currently on the market for food allergy are mainly antihistamines, such as chlorpheniramine, loratadine, promethazine, etc. These drugs often treat the symptoms but not the root cause, and are highly res...

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Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of antiallergic sulfated polysaccharide in order to overcome the low problem of existing sulfated polysaccharide antiallergic activity, and it adopts common sulfated polysaccharide as raw material to carry out modification processing, and common sulfated polysaccharide originates from marine brown algae (such as kelp, Hijiki, Sargassum, Undaria pinnatifida, Sargassum, Stagweed, etc.), marine red algae (such as red hair algae, Eucheuma, Gracilaria, seaweed, Gemweed, Porphyra, Seaweed, Partridge, etc.) and Micrococcus have high anti-allergic activity after removing divalent metal ions (activation of sulfate groups), reducing molecular weight, and increasing retention of sulfate groups

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