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Probiotic microbial inoculum, cotton swab, and preparation method and application of cotton swab

A technology of probiotics and bacterial agents, applied in pharmaceutical formulations, other medical devices, medical preparations containing active ingredients, etc., can solve the drug resistance of bacteria, the destruction of beneficial bacteria and neutral bacteria, and the unsatisfactory treatment effect of CSOM and other problems, to achieve the effect of less viable bacteria, stable shelf life, and safe and reliable bacteria.

Pending Publication Date: 2020-05-22
SHANGHAI URBAN CONSTR VOCATIONAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical application of CSOM antibiotics (systemic application of antibiotics in acute attacks) is mostly empirical medication, without evidence-based medical evidence, especially for middle ear mastoid submucosal vascular scar fibrosis, which requires a large amount of medication to achieve effective concentration, but a large amount of long-term medication Not only does the pathogenic bacteria develop drug resistance, but the beneficial bacteria and neutral bacteria are also destroyed, so the treatment effect of CSOM is not ideal, and the large dose or long-term use of broad-spectrum antibiotics and the decline of the body's immune function will make the ear canal flora Imbalance, will trigger the occurrence of inflammation, thus a vicious circle

Method used

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  • Probiotic microbial inoculum, cotton swab, and preparation method and application of cotton swab
  • Probiotic microbial inoculum, cotton swab, and preparation method and application of cotton swab
  • Probiotic microbial inoculum, cotton swab, and preparation method and application of cotton swab

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Probiotic Swabs

[0042] Such as figure 1 As shown, the probiotic cotton swab contains probiotic bacteria agent, dry ice, fiber, cylinder, lining film and grid plate, and the cylinder is divided into upper cylinder 1, middle cylinder 2 and lower cylinder 3, all of which are Hollow structure, the cylinder can be made of wood, bamboo or plastic, the upper cylinder 1 and the middle cylinder 2, the middle cylinder 2 and the lower cylinder 3 are combined by thread rotation; the upper end of the upper cylinder 1 is wound with fibers 4, The fiber 4 can be wound into a half-mountain shape, a cylinder or a cone shape, and the surface is in the shape of a concave-convex thread. The fiber 4 can be cotton fiber, a silk-cotton mixture, non-woven fabric or bamboo fiber; the central column 2 contains the probiotic bacteria The probiotic bacteria agent is sealed in the middle cylinder 2 by the inner lining film 5 arranged at the upper end of the central cylinder 2 and the i...

Embodiment 2

[0046] Embodiment 2: the preparation of probiotic cotton swab

[0047] (1) Cultivation of probiotics: select secondary activated probiotics to be inoculated into the culture medium for 20 to 50 hours, and the probiotics are Staphylococcus epidermidis and Bifidobacterium coryniform, and the inoculum size is 5% to 10%;

[0048] (2) Freeze-drying of probiotics: the cultured probiotics are collected by centrifugation, freeze-dried, and the moisture is lower than 5%, and the freeze-dried powder is stored in a -18°C refrigerator for later use;

[0049] (3) Pulverizing the probiotic freeze-dried powder at low temperature and passing through an 80-mesh sieve;

[0050] (4) Mix each probiotic bacteria powder according to the following ratio of the total number of bacteria to obtain the probiotic bacterial agent;

[0051] Probiotics Proportion of total bacteria count (%) Staphylococcus epidermidis 40 Bifidobacterium coryneformis 60

[0052] (5) Fill the prob...

Embodiment 3

[0056] The difference from Example 2 is that the composition of the probiotic bacterial agent and the probiotic cotton swab is as follows:

[0057] (1) Probiotics

[0058] Probiotics Proportion of total bacteria count (%) Staphylococcus epidermidis 20 Bifidobacterium coryneformis 80

[0059] (2) Probiotic cotton swabs

[0060] components Quality score (%) Probiotics 1 dry ice 99

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Abstract

The invention discloses a probiotic microbial inoculum, a cotton swab, and a preparation method and application of the cotton swab. The probiotic microbial inoculum comprises staphylococcus epidermidis and bifidobacterium coryneforme, and the cotton swab comprises the probiotic microbial inoculum and dry ice. The preparation method of the probiotic microbial inoculum and the preparation method ofthe cotton swab are simple, and the microbial inoculum is prepared into a powder form, so that the viable count of the microbial inoculum can be effectively maintained. The cotton swab is designed tobe in a separation mode, probiotic microbial powder and dry ice are stored separately, and mixing is carried out immediately when in use, so that activity of the probiotic microbial inoculum is effectively maintained, use is convenient, and the dosage can be flexibly adjusted. The cotton swab is used for administration by an ear canal, and the dry ice sublimates to enable probiotics to penetrate deep into the ear canal, so that the probiotics can be planted more deeply, the effect is more direct and effective, and the effect is quick.

Description

technical field [0001] The present invention relates to a probiotic bacterial agent, a cotton swab and its preparation method and application, in particular to a probiotic bacterial agent which can be prepared as a medicine for treating ear canal diseases and its preparation method and application, and also relates to a probiotic bacterial agent which can be used to treat ear canal diseases. Cotton swab for tract diseases and its preparation method and application. Background technique [0002] Normal flora exists in the part where the host communicates with the outside world. There are a large number of normal flora in the external auditory canal. They restrict each other, maintain the acidic environment (pH3-5) of the ear canal skin, and play physiological functions such as nutrition, antagonism, and immunity. The results of the analysis of the ear canal flora of the elderly show that compared with presbycusis patients, the elderly with normal hearing have fewer microecolo...

Claims

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Application Information

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IPC IPC(8): A61K35/745A61K35/741A61P27/16A61F11/00A61M31/00
CPCA61K35/745A61K35/741A61P27/16A61F11/00A61M31/00A61M2210/0662A61K2300/00A61M2210/005
Inventor 王春华尚胜美韦德祥左迪曲瑞丹唐鹤宸王文纨
Owner SHANGHAI URBAN CONSTR VOCATIONAL COLLEGE