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New application of bowel-relaxing composition capable of taking five fruits and vegetables as raw materials for increasing intestinal moisture and lubricating intestines

A new application and formulation technology, applied in application, plant raw materials, medical raw materials derived from fungi, etc., can solve problems such as unsuitable for constipation, severe constipation, and destruction of flora structure.

Pending Publication Date: 2020-05-29
HEBEI YUZHILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These cathartics act like high-pressure water guns in our intestines. Although they can take away the stool, they will also take away the probiotics in the intestines and destroy the flora structure in the intestines. Once they are stopped, constipation will occur. It is more serious, and long-term use will cause more intestinal diseases
[0028] 3. Products based on traditional Chinese medicine are not suitable for all types of constipation due to the limitations of the population using Chinese medicinal materials

Method used

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  • New application of bowel-relaxing composition capable of taking five fruits and vegetables as raw materials for increasing intestinal moisture and lubricating intestines
  • New application of bowel-relaxing composition capable of taking five fruits and vegetables as raw materials for increasing intestinal moisture and lubricating intestines

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 Aquaporin pharmacological experiment

[0038] In order to study whether TTC has an effect on water metabolism. In this experiment, IHC was used to detect the expression of AQP9 in colon tissue and WB was used to detect the expression changes of AQP3, AQP9 and GC-C / cGMP in colon tissue.

[0039] 1 Sample collection and storage

[0040] Serum sample: After 3 weeks of the experiment, the rats were fasted for 12 hours, weighed, and then anesthetized with 10% chloral hydrate (0.3 mL / 100 g), and blood was collected from the abdominal aorta. After the blood taken out was naturally coagulated, it was centrifuged at 3000rpm for 10 minutes to obtain a serum sample, which was stored at -80°C for testing;

[0041] Tissue samples: After 3 weeks of the experiment, the rats were fasted for 12 hours, weighed, and then anesthetized with 10% chloral hydrate (0.3mL / 100g), and the colon tissue was taken out immediately, rinsed with normal saline and blotted dry with medical ...

Embodiment 2

[0091] 1. Experimental animals: NIH mice, SPF grade, body weight 18-23g, both male and female.

[0092] 2. Drugs: TTC powder; compound diphenoxylate.

[0093] 3. Reagents: paraffin oil, ether, senna leaf water.

[0094] 4. Instruments: FA1104 electronic analytical balance, X102 sphygmomanometer, medical catheter (No. 8).

[0095] 5. Antidiarrheal effect of TTC on senna-induced mouse diarrhea model: NIH mice (half and half male and half) were randomly divided into model groups, TTC low and high dose groups, compound diphenoxylate group (dose was 2.6mg · kg / d).

[0096] The TTC group was pre-administered for 3 days, once a day, and the compound diphenoxylate group was administered once on the third day. Fasted for 12 hours before the last administration, and 1 hour after administration, the mice were fed with 0.5 mL / mouse of 1 kg / L senna leaf decoction. Then the mice were placed on a wire net lined with filter paper, each mouse was covered with a large glass funnel, and the ...

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Abstract

The invention discloses a new purpose of a bowel-relaxing composition capable of taking five fruits and vegetables as raw materials. The invention provides a purpose of the bowel-relaxing compositioncapable of taking five fruits and vegetables as raw materials for preparing a food or medicine capable of increasing intestinal moisture and lubricating intestines. The bowel-relaxing composition is BianTong Pai Tian Tian Jiao Nang consisting of Cucurbita moschata (Duch. ex Lam.) Duch. ex Poiret, Aloe vera (Haw.) Berg, poria cocos, tremella fuciformis Berk. and xylooligosaccharide with fineness of5-20 [mu] m. Researches discover that the bowel-relaxing composition can stimulate intestinal juice to be secreted through the activation of guanylate cyclase (GC-C). Due to the increment of intestinal juice secretion, an expression quantity of aquaporin 3 (AQP3) is increased, and the intestinal juice is transmitted into blood vessels from the enteric cavity. Meanwhile, the composition stimulatesthe expression of AQP9 to increase mucus secretion. A new means is provided for increasing intestinal moisture and lubricating intestines, and the invention has a wide clinical application prospect.

Description

technical field [0001] The invention relates to a laxative prescription and its new application, belonging to the field of traditional Chinese medicine. Background technique [0002] 1. Aquaporin [0003] Aquaporin, also known as aquaporin, is a protein located on the cell membrane (intrinsic membrane protein), which forms a "pore" on the cell membrane, which can control the entry and exit of water in the cell, just like "the water pump of the cell" "Same. [0004] The water channel was discovered by American scientist Peter Agre of the Johns Hopkins University School of Medicine. He and Rodriguez of the Howard Hughes Medical Research Center of the Rockefeller University confirmed the structure of the potassium ion channel through X-ray crystallography. McKinnon shared the 2003 Nobel Prize in Chemistry. [0005] Agre et al. found a 28kD hydrophobic transmembrane protein called channel-forming integral membrane protein 28 (channel-forminginte-gralmembraneprotein, CHIP28) w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A23L33/00A61K9/48A61P11/10A61K31/702A61K36/07A61K36/076A61K36/42
CPCA23V2002/00A61K9/48A61K31/702A61K36/07A61K36/076A61K36/42A61K36/886A61K36/896A23L33/00A61P11/10A61K2300/00A23V2200/32
Inventor 朱志铭赵大鹏张赞李积珍
Owner HEBEI YUZHILIN PHARMA