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Wound care spray

A spray and wound technology, applied in the field of medicine, can solve the problems of easy ingrowth of granulation tissue on the wound surface, failure to achieve an ideal curative effect, and easy passage of pathogens, so as to reduce various exudation and inflammatory reactions, and reduce the adhesion of dressings and wound surfaces. , the effect of high chemical reactivity

Inactive Publication Date: 2020-05-29
张秀燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned wound treatment and medication are prone to infection and scarring. If ulcers and other serious cases occur, the above-mentioned methods and formulas cannot achieve the desired curative effect, and may even cause a decline in immunity, which brings many troubles to the life, study, and work of the patient.
[0004] Wound dressing is another common wound care material currently on the market. However, this material is more or less unable to keep the wound moist and delays wound healing; the dressing fibers are easy to fall off, causing foreign body reactions and affecting healing; It grows into the mesh of the dressing, which can cause pain when changing the dressing; when the dressing is soaked, pathogens can easily pass through; when changing the dressing, it is easy to damage the new tissue; the defect of heavy dressing workload
[0005] The Chinese invention patent with the application publication number CN 104688981A discloses a wound care spray, which is composed of the following raw materials and components: 5-15 parts of Panax notoginseng, 6-15 parts of safflower, 3-9 parts of myrrh, 7-15 parts of dried blood, 2-6 parts of angelica, 5-20 parts of Jiulixiang, 4-12 parts of Tianqi powder, 4-10 parts of borneol, 3-9 parts of mint, 4-16 parts of corydalis, 6-10 parts of wintergreen 4-12 parts of Nadihua Zizhu, 6-12 parts of Great Thistle, 7-15 parts of Calendula officinalis, 2-4 parts of methyl salicylate, 2-5 parts of ginger camphor oil, 2-6 parts of cinnamon oil part; the medicine of this invention is made of natural pure Chinese medicine, and the power of the medicine can reach the deep part of the affected part by spraying. Any toxic side effects, but the composition is complex, the cost is high, and the ability of anti-infection and anti-inflammatory response needs to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A wound care spray, characterized in that it is made of the following raw materials in parts by weight: 6 parts of borneol modified hyperbranched polyglycerol, 5 parts of water-soluble chitosan quaternary ammonium salt, 1 part of Lycium barbarum polysaccharide, 0.5 parts of vitamin E 0.1 part of polyaminopropyl biguanide amidated norfloxacin, 5 parts of Chinese herbal medicine extract, 90 parts of distilled water.

[0029] The preparation method of the borneol-modified hyperbranched polyglycerol comprises the following steps: after mixing 0.3 g of 5-norbornene-2-acyl chloride, 15 g of hyperbranched polyglycerol, 2 g of anhydrous pyridine, and 45 g of tetrahydrofuran, in a nitrogen atmosphere, Stir in an ice bath for 0.3 hours, then stir and react at 35° C. for 4 hours, and then remove the solvent and anhydrous pyridine by rotary evaporation to obtain borneol-modified hyperbranched polyglycerol.

[0030] The preparation method of the polyaminopropyl biguanide amidated no...

Embodiment 2

[0035] A wound care spray, characterized in that it is made of the following raw materials in parts by weight: 7 parts of borneol modified hyperbranched polyglycerol, 6 parts of water-soluble chitosan quaternary ammonium salt, 2 parts of Eucommia polysaccharide, 1 part of vitamin C , 0.2 parts of polyaminopropyl biguanide amidated norfloxacin, 6.5 parts of Chinese herbal medicine extract, 93 parts of distilled water.

[0036] The preparation method of the borneol-modified hyperbranched polyglycerol comprises the following steps: after mixing 0.3 g of 5-norbornene-2-acyl chloride, 16.5 g of hyperbranched polyglycerol, 2.5 g of anhydrous pyridine, and 49 g of dichloromethane, In a helium atmosphere, stir in an ice bath for 0.4 hours, then stir and react at 37° C. for 4.5 hours, and then remove the solvent and anhydrous pyridine by rotary evaporation to obtain borneol-modified hyperbranched polyglycerol.

[0037] The preparation method of the polyaminopropyl biguanide amidated no...

Embodiment 3

[0042] A wound care spray, characterized in that it is made from the following raw materials in parts by weight: 9 parts of borneol-modified hyperbranched polyglycerol, 8 parts of water-soluble chitosan quaternary ammonium salt, 2.5 parts of polysaccharides, 1.5 parts of vitamin K 0.25 parts of polyaminopropyl biguanide amidated norfloxacin, 7.5 parts of Chinese herbal medicine extract, and 100 parts of distilled water.

[0043] The preparation method of the borneol-modified hyperbranched polyglycerol comprises the following steps: 0.3 g of 5-norbornene-2-acyl chloride, 18 g of hyperbranched polyglycerol, 3 g of anhydrous pyridine, and N,N-dimethylformamide After mixing 52 g, stir in an ice bath in a neon atmosphere for 0.45 hours, then stir and react at 40°C for 5 hours, and then remove the solvent and anhydrous pyridine by rotary evaporation to obtain borneol-modified hyperbranched polyglycerol.

[0044] The preparation method of described polyaminopropyl biguanide amidated ...

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Abstract

The invention discloses a wound care spray. The spray is characterized by being prepared from the following raw materials in parts by weight: 6-12 parts of borneol modified hyperbranched polyglycerol,5-10 parts of a water-soluble chitosan quaternary ammonium salt, 1-4 parts of plant polysaccharides, 0.5-2.5 parts of vitamins, 0.1-0.4 part of polyaminopropyl biguanide amidated norfloxacin, 5-10 parts of traditional Chinese herbal medicine extract, and 90-110 parts of distilled water. The invention also discloses a preparation method of the wound care spray. The wound care spray disclosed in the invention can avoid wound infection, promote wound healing and new skin growth, can use a spraying manner to reach the deep part of an affected part, and has a good curative effect on wounds withoutany side effects, and no scars are left after healing.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a wound care spray. Background technique [0002] As the largest organ of the human body, the skin plays a very important role in the human body. It is an important organ to control the evaporation of water in the body and prevent external bacteria from invading the human body. In daily life, skin damage often occurs. Trauma such as burns and scalds is one of the common accidental injuries in people's daily life. Trauma will destroy the natural antibacterial barrier defense ability of normal skin, so it will not only cause the patient's Severe pain, and it is easy to cause the injured wound to become deeper and deeper, complicated by infection, thus causing internal injury to the patient, so timely and correct treatment of the trauma is necessary. [0003] In the prior art, for the treatment of wounds such as burns, scalds, postoperative wound inflammation, traumatic ulcers, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/90A61K9/12A61K47/34A61K47/59A61P17/02A61P31/04C08G65/337C08G73/00A61K31/496A61K31/715A61K31/722A61K31/765A61K36/185A61K36/19A61K36/27A61K36/282A61K36/287A61K36/515A61K36/58A61K36/634A61K36/86
CPCA61K9/0014A61K9/12A61K31/496A61K31/715A61K31/722A61K31/765A61K36/185A61K36/19A61K36/27A61K36/282A61K36/287A61K36/515A61K36/58A61K36/634A61K36/86A61K36/896A61K36/90A61K47/34A61K47/59A61P17/02A61P31/04C08G65/337C08G73/00A61K2300/00
Inventor 张秀燕
Owner 张秀燕
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