Wound care spray
A spray and wound technology, applied in the field of medicine, can solve the problems of easy ingrowth of granulation tissue on the wound surface, failure to achieve an ideal curative effect, and easy passage of pathogens, so as to reduce various exudation and inflammatory reactions, and reduce the adhesion of dressings and wound surfaces. , the effect of high chemical reactivity
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Embodiment 1
[0028] A wound care spray, characterized in that it is made of the following raw materials in parts by weight: 6 parts of borneol modified hyperbranched polyglycerol, 5 parts of water-soluble chitosan quaternary ammonium salt, 1 part of Lycium barbarum polysaccharide, 0.5 parts of vitamin E 0.1 part of polyaminopropyl biguanide amidated norfloxacin, 5 parts of Chinese herbal medicine extract, 90 parts of distilled water.
[0029] The preparation method of the borneol-modified hyperbranched polyglycerol comprises the following steps: after mixing 0.3 g of 5-norbornene-2-acyl chloride, 15 g of hyperbranched polyglycerol, 2 g of anhydrous pyridine, and 45 g of tetrahydrofuran, in a nitrogen atmosphere, Stir in an ice bath for 0.3 hours, then stir and react at 35° C. for 4 hours, and then remove the solvent and anhydrous pyridine by rotary evaporation to obtain borneol-modified hyperbranched polyglycerol.
[0030] The preparation method of the polyaminopropyl biguanide amidated no...
Embodiment 2
[0035] A wound care spray, characterized in that it is made of the following raw materials in parts by weight: 7 parts of borneol modified hyperbranched polyglycerol, 6 parts of water-soluble chitosan quaternary ammonium salt, 2 parts of Eucommia polysaccharide, 1 part of vitamin C , 0.2 parts of polyaminopropyl biguanide amidated norfloxacin, 6.5 parts of Chinese herbal medicine extract, 93 parts of distilled water.
[0036] The preparation method of the borneol-modified hyperbranched polyglycerol comprises the following steps: after mixing 0.3 g of 5-norbornene-2-acyl chloride, 16.5 g of hyperbranched polyglycerol, 2.5 g of anhydrous pyridine, and 49 g of dichloromethane, In a helium atmosphere, stir in an ice bath for 0.4 hours, then stir and react at 37° C. for 4.5 hours, and then remove the solvent and anhydrous pyridine by rotary evaporation to obtain borneol-modified hyperbranched polyglycerol.
[0037] The preparation method of the polyaminopropyl biguanide amidated no...
Embodiment 3
[0042] A wound care spray, characterized in that it is made from the following raw materials in parts by weight: 9 parts of borneol-modified hyperbranched polyglycerol, 8 parts of water-soluble chitosan quaternary ammonium salt, 2.5 parts of polysaccharides, 1.5 parts of vitamin K 0.25 parts of polyaminopropyl biguanide amidated norfloxacin, 7.5 parts of Chinese herbal medicine extract, and 100 parts of distilled water.
[0043] The preparation method of the borneol-modified hyperbranched polyglycerol comprises the following steps: 0.3 g of 5-norbornene-2-acyl chloride, 18 g of hyperbranched polyglycerol, 3 g of anhydrous pyridine, and N,N-dimethylformamide After mixing 52 g, stir in an ice bath in a neon atmosphere for 0.45 hours, then stir and react at 40°C for 5 hours, and then remove the solvent and anhydrous pyridine by rotary evaporation to obtain borneol-modified hyperbranched polyglycerol.
[0044] The preparation method of described polyaminopropyl biguanide amidated ...
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