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A kind of amphiphilic block copolymer, absorbable bone wax and preparation method

A block copolymer and amphiphilic technology, applied in drug delivery, surgery, surgical adhesives, etc., can solve problems such as unsatisfactory hemostatic effect, poor natural material source and process stability, immunogenic allergies, etc., to improve safety Sexuality and handling properties, rapid disintegration and degradation, and the effect of reducing cytotoxicity

Active Publication Date: 2021-07-16
CHENGDU EHANRI MEDICAL TECH LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of material is often in the form of sponge or powder, and has a significant hemostatic effect in routine soft tissue bleeding, but the hemostatic effect is often not ideal when applied to spongy bone wounds.
In addition, the source of natural materials and process stability are poor, and there are various problems such as immunogenicity and allergies
There are currently no absorbable bone wax products of this type on the market

Method used

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  • A kind of amphiphilic block copolymer, absorbable bone wax and preparation method
  • A kind of amphiphilic block copolymer, absorbable bone wax and preparation method
  • A kind of amphiphilic block copolymer, absorbable bone wax and preparation method

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Embodiment 1

[0060] This embodiment discloses the preparation method of the amphiphilic block copolymer of the present invention, specifically:

[0061] Weigh 10.2 g of the dried polyethylene glycol 1000, 29.4 g of trimethylene carbonate, and 14.0 g of ε-caprolactone, add them into a 250 mL three-necked bottle, and then add 3 mg of stannous octoate as a catalyst. Under the protection of nitrogen, raise the temperature to 150°C, stir and react for 12 hours, then add ε-caprolactone 46.5g, continue to stir and react for 36 hours, cool to room temperature, purify and dry to obtain an amphiphilic block copolymer as 1# bone wax.

Embodiment 2

[0063] This embodiment discloses the preparation method of the amphiphilic block copolymer of the present invention, specifically:

[0064] Weigh 8.6 g of the dried polyethylene glycol monomethyl ether 600, 16.8 g of trimethylene carbonate, and 46.6 g of ε-caprolactone, add them into a 250 mL three-necked bottle, and then add 3 mg of stannous octoate as a catalyst. Under the protection of nitrogen, raise the temperature to 150°C, stir and react for 24 hours, then add ε-caprolactone 28.0g, continue to stir and react for 48 hours, cool to room temperature, purify and dry to obtain an amphiphilic block copolymer as 2# bone wax.

Embodiment 3

[0066] This embodiment discloses the preparation method of bone wax of the present invention, specifically:

[0067] Weigh 86g of 1# bone wax and 14g of four-armed polyethylene glycol 10000, add it into a 250mL three-necked bottle, heat up to 80°C until the materials are completely melted, stir and blend for 2 hours, and cool to room temperature to obtain 3# bone wax.

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Abstract

The invention discloses an amphiphilic block copolymer, absorbable bone wax and a preparation method, and belongs to the technical field of medicines. In the amphiphilic block copolymer of the present invention, the hydrophilic segment is a water-soluble polyoxyethylene chain, and the hydrophobic segment is a semi-crystalline ester chain; the ester chain is a dichotomy of trimethylene carbonate and ε-caprolactone. Metapolymer; the general structural formula of the amphiphilic block copolymer is as follows: PEG (—PTCL) n , wherein n is 1-8; wherein, PEG is polyethylene glycol or polyethylene glycol monomethyl ether; PTCL is a binary copolymer of trimethylene carbonate and ε-caprolactone. When the amphiphilic block copolymer of the present invention is used as bone wax, it has good plugging performance, rapid disintegration without occupying space, does not affect bone healing, good handling performance, good cell compatibility, low local acidity, easy Stabilize production.

Description

technical field [0001] The invention belongs to the technical field of hemostatic materials, and in particular relates to an amphiphilic block copolymer, absorbable bone wax and a preparation method. Background technique [0002] Clinically, bone destruction is often involved in orthopedics, thoracic surgery, neurosurgery and other surgical procedures, resulting in blood oozing from cancellous bone wounds. Due to the loose tissue structure, rich blood supply, dense sinusoids, poor vasoconstriction in the tissue, platelet aggregation, and difficulty in adhering blood clots to the bone wound, it is often difficult to rely on vasoconstriction to stop bleeding during surgery. , It is also difficult to effectively stop bleeding by conventional methods such as electrocoagulation, clamping, hemostatic gauze, and gelatin sponge packing. Currently, bone wax is commonly used clinically for hemostasis of cancellous bone wounds. The mechanism of bone wax hemostasis is physical packing...

Claims

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Application Information

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IPC IPC(8): C08G63/664C08G63/64C08G63/78C08G63/85A61L24/00A61L24/04
CPCA61L24/001A61L24/0042A61L24/046A61L2400/04C08G63/64C08G63/664C08G63/78C08G63/85C08L67/04C08L69/005
Inventor 潘高峰高建丰曾静雯郑少东朱志远
Owner CHENGDU EHANRI MEDICAL TECH LTD
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