Preparation method and application of cross-linked polymer
A technology of cross-linked polymer and polymerization reaction, applied in the field of microneedles, can solve the problems of low bioavailability and difficult use of puerarin drugs, and achieve the effects of good mechanical properties, simple and easy method, and good solubility.
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Embodiment 1
[0040] (1) Preparation of a cross-linked polymer, accurately weigh 1.0g dextrose, 1.0g sodium carboxymethylcellulose, dissolve in 20mL deionized water, dissolve at room temperature, accurately weigh 20% lemon Acid, stir to dissolve, mix completely, react in a water bath at 50°C for 10 hours, adjust pH=5 with 50% NaOH to obtain a cross-linked polymer;
[0041] (2) Use the above-mentioned cross-linked polymer to further produce soluble microneedles: measure 2 mL of the cross-linked polymer in step (1), add trypan blue, and mix well to obtain a 0.1 mg / mL trypan blue mixture;
[0042] (3) Weigh 2 mL of the polymer in step (1), add rhodamine B dyeing agent, and mix evenly to obtain a 0.1 mg / mL rhodamine B mixed solution;
[0043] (4) Put the microneedle mold into a 5mL small centrifuge tube, pipette 300 μL of the mixture in step (2), and spread it on the surface of the mold; set the centrifugal speed to 3000 rpm, and centrifuge for 60 minutes for the first time ,take out. Pipette...
Embodiment 2
[0046] (1) Preparation of a cross-linked polymer, accurately weigh 1.0g dextrose, 1.0g sodium carboxymethylcellulose (CMC), be dissolved in 20mL deionized water, dissolve at room temperature, accurately weigh the mass fraction of 20% citric acid, stirred and dissolved, mixed completely, reacted for 10 hours in a water bath at 50°C, pH = 1, and the cross-linking results were tested by infrared figure 2 ,from figure 2 It can be seen that the infrared spectrogram of the product of embodiment 2 is at 1725.66cm -1 A new ester bond peak appears at , indicating successful ester formation with citric acid. It indicated that sodium carboxymethyl cellulose and galactose had a cross-linking polymerization reaction, and the cross-linked polymer was successfully prepared.
[0047](2) Dry the cross-linked polymer in step (1) in an oven at 40°C to form a film, weigh the mass of the film at this time with a precision balance, and then place it in an air temperature of 30°C, and place a cu...
Embodiment 3
[0050] (1) Preparation of a cross-linked polymer, accurately weigh 1.0g dextrose, 1.0g sodium carboxymethylcellulose, dissolve in 20mL deionized water, dissolve at room temperature, accurately weigh 20% of the Citric acid, stir to dissolve, mix completely, react in a water bath at 50°C for 10 hours, adjust the pH to 5 with 50% NaOH, and the cross-linking results of the infrared test are as follows: figure 2 ,from figure 2 It can be seen that the infrared spectrum of the product of embodiment 3 and the infrared spectrum of the CMC-galactose cross-linked polymer Figure 1 The results show that sodium carboxymethyl cellulose and galactose undergo a cross-linking polymerization reaction, and a cross-linked polymer is successfully prepared.
[0051] (2) Dry the polymer in step (1) in an oven at 40°C to form a film, weigh the mass of the film at this time with a precision balance, and then place it in a drying pot with a cup of 100mL water at an air temperature of 30°C In a simu...
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