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Medicine-carrying silk fibroin bone repair screw and preparation method thereof

A technology of silk fibroin and protein bone, applied in medical science, surgery, additive processing, etc., can solve problems such as poor compliance, achieve good affinity, solve urgent needs, and promote good integration.

Pending Publication Date: 2020-06-05
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, silk fibroin bone nails were usually prepared by casting molds or cutting blocks. Due to the large individual differences in bone defects in patients, the traditional preparation methods have defects such as poor compliance.

Method used

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  • Medicine-carrying silk fibroin bone repair screw and preparation method thereof
  • Medicine-carrying silk fibroin bone repair screw and preparation method thereof
  • Medicine-carrying silk fibroin bone repair screw and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of a 3D printed drug-loaded silk fibroin bone repair screw (1) Collect CT image data of the patient, analyze and design the shape and interior of the individualized implant material for the patient in the three-dimensional image software Pore ​​Structure. Among them, the width of the rod is 10-1000 μm, and the pore diameter is 0.1-100 μm. Fill and expand the image with cube structural units to obtain a three-dimensional image of the target implant, and import the three-dimensional image file into a 3D printer;

[0050] (2) take by weighing 10g silkworm cocoons after removing silkworm chrysalis and put into 0.5% (w / w) Na 2 CO 3 Boil in the solution for 3 times, each time for 30min, the liquor ratio is 1:50. After degumming, wash away the debris and cutin with distilled water while it is hot. Dry at 70°C to obtain pure silk fibroin fibers, which are stored for future use. Dissolve the dried pure silk fibroin fibers in CaCl at 80°C 2 :C 2 h 5 O...

Embodiment 2

[0056] Embodiment 2 Preparation of a silk fibroin bone filling gel

[0057] (1) Take by weighing 6g of silkworm cocoons after removing silkworm chrysalis and put into 0.5% (w / w) Na 2 CO 3 Boil in the solution for 3 times, each time for 30min, the liquor ratio is 1:50. After degumming, wash away the debris and cutin with distilled water while it is hot. Dry at 60°C to obtain pure silk fibroin fibers, which are stored for future use. Dissolve the dried pure silk fibroin fibers in CaCl at 80°C 2 :C 2 h 5 OH:H 2 O (the molar ratio is 1:2:8) in the ternary mixed solvent, the bath ratio is 1:15, and the silk fibroin fiber is completely dissolved after 40 minutes to obtain the silk fibroin solution;

[0058] (2) Put the silk fibroin mixed solution described in (1) into a dialysis bag, place it in a 2L beaker for dialysis for three days, add 1.5L ultrapure water as the dialysis medium for dialysis, and replace the dialysis medium every 3 hours during the period. To remove meta...

Embodiment 3

[0061] Example 3: The effect of silk fibroin implant material on the morphology of osteoblasts is improved.

[0062] This example shows the promoting effect of the silk fibroin implant material prepared in Example 2 on the growth morphology and effect of osteoblasts compared with the alloy material.

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Abstract

The invention discloses a medicine-carrying silk fibroin bone repair screw and a preparation method thereof and relates to the technical field of biomedical materials. According to the medicine-carrying silk fibroin bone repair screw and the preparation method thereof, a 3D printed medicine-carrying bone repair screw based on a silk fibroin material is proposed and developed, a medicine is locallyreleased through decomposition of silk fibroin after implantation of the bone repair screw, so that the bone repair screw has the function of inhibiting bacterial infection while having basic fixation and bone formation functions.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, more specifically, the invention relates to a drug-loaded silk fibroin bone repair screw and a preparation method thereof. Background technique [0002] With the rapid development of modern society, the number of patients undergoing bone defect repair and fracture internal fixation has increased rapidly, and patients have put forward higher requirements for safe and effective implants and implantable medical devices. Bone repair screws are commonly used internal fixation devices and play an irreplaceable role in bone defect repair and functional reconstruction. However, studies have shown that the incidence of surrounding infection is always high in bone fixation of infected or potentially infected wounds, whether it is bone nails made of traditional metal materials or new absorbable polymer materials. Infections around implants can lead to loosening and failure of implants, fractur...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14A61L31/16B33Y10/00B33Y70/00B33Y80/00
CPCA61L31/047A61L31/148A61L31/16A61L2300/21A61L2300/216A61L2300/404A61L2300/406A61L2300/604B33Y10/00B33Y70/00B33Y80/00C08L89/00
Inventor 王淑君邬琼叶田田刘珺马翔宇
Owner SHENYANG PHARMA UNIVERSITY
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