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Oral drug-loaded patch film and preparation method thereof, and oral drug-loaded patch film assembly and preparation method thereof

A technology of drug loading and oral cavity, which is applied in drug combination, pharmaceutical formula, drug delivery, etc., can solve the problems of thick thickness, easy to fall off, and barrier effect to reduce the effective absorption of drugs, so as to achieve the effect of improving the therapeutic effect and not easy to fall off

Active Publication Date: 2020-06-12
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing oral adhesive preparations still have the following problems: (1) in the moist environment of the oral cavity, the wet adhesion is insufficient and easy to fall off; (2) the drug release rate is uncontrollable; (3) the area is small, and it cannot be used according to different diseases. The size of the lesion is specifically tailored, and the thickness is thick and the comfort is insufficient, resulting in poor patient compliance; (4) The barrier effect of the oral mucosal epithelium and mucus layer reduces the effective absorption of drugs

Method used

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  • Oral drug-loaded patch film and preparation method thereof, and oral drug-loaded patch film assembly and preparation method thereof
  • Oral drug-loaded patch film and preparation method thereof, and oral drug-loaded patch film assembly and preparation method thereof
  • Oral drug-loaded patch film and preparation method thereof, and oral drug-loaded patch film assembly and preparation method thereof

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preparation example Construction

[0068] The embodiment of the present invention also provides a preparation method of the above-mentioned oral drug-loaded patch, comprising the following steps:

[0069] Loading the drug-loaded particles on the carrier film, specifically, the loading step includes: mixing the first solution containing the drug-loaded particles with the second solution containing a dopa-modified polymer, Then freeze-dry to form the carrier film, and the drug-loaded particles are loaded on the carrier film. The above operation steps can ensure the formation of oral drug-loaded film.

[0070] Wherein, the preparation step of the first solution includes: mixing and dissolving the coating material and the active ingredient, then adding it to a poor solvent, stirring and mixing, and then centrifuging to form a centrifugal sediment; at this time, the coating material has wrapped the active ingredient, so that the active ingredient Can be sustained slow release.

[0071] Further, both the coating ma...

Embodiment 1

[0082] The present embodiment provides a preparation method of an oral drug-loaded patch, comprising the following steps:

[0083] S1, preparing the first solution;

[0084] Dissolve 40mg of polylactic-co-glycolic acid (PLGA) and 4mg of dexamethasone (Dex) in 2ml of acetonitrile solution, then slowly drop into 40ml of deionized water, stir and react at 25°C for 4 hours, and then centrifuge at 12000rpm for 20min at high speed to form sink, and washed repeatedly three times to form a centrifugal sediment.

[0085] In 40ml of deionized water, tris (Tris) was added to make the pH of the solution 10, and then 0.5mg of dopamine hydrochloride (C 8 h 11 NO 2 HCl), stir until it is completely dissolved, add the aforementioned centrifugal sediment and let it dissolve, then, stir and react at 25°C for 6h, then centrifuge at 12000rpm for 20min to collect the sediment after centrifugation, and wash the sediment several times , forming a first solution, the first solution contains PLGA-...

Embodiment 2

[0094] Example 2 When preparing the second solution, 4 mmol of 3,4-dihydroxyphenylalanine (DOPA) was added, and the number of the polymer modified by the dopa-like substance formed was PVA-DOPA2;

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Abstract

The invention relates to the technical field of oral local medication, in particular to an oral drug-loaded patch film, a preparation method thereof, an oral drug-loaded patch film assembly and a preparation method of the oral drug-loaded patch film assembly. The oral drug-loaded patch film comprises a carrier film and drug-loaded particles loaded on the carrier film, the carrier film is a film which is formed by a dopa substance modified polymer and has wet adhesion; the drug-loaded particles comprise active ingredients and wrapping materials, and the wrapping materials wrap the active ingredients and then slowly release the active ingredients. The oral drug-loaded patch film has good wet adhesion, is not easy to fall off after being adhered to a wound surface, can slowly and continuouslyrelease active ingredients and control the release of the active ingredients, and has good comfort.

Description

technical field [0001] The present invention relates to the technical field of local oral administration, in particular to an oral drug-loaded patch and a preparation method thereof, an oral drug-loaded patch component and a preparation method thereof. Background technique [0002] Oral mucosal disease is a general term for a series of various types of diseases involving the oral mucosa, including oral mucosal ulcer diseases, potentially malignant diseases of the oral mucosa, and bullous diseases. The etiology of this kind of disease is complex, the course of the disease is protracted, the treatment is difficult, and even systemic disease or cancer may occur, which seriously threatens human health. The oral mucosal drug delivery route has received more and more attention in recent years, because this delivery method not only has good prospects in the development of drug sustained-release systems, but also can effectively avoid the transient effect, gastrointestinal enzyme de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/34A61K31/573A61P1/02
CPCA61K9/006A61K9/7007A61K31/573A61K47/32A61K47/34A61P1/02
Inventor 胡杉杉王剑万乾炳
Owner SICHUAN UNIV