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Sea cucumber polysaccharide composition as well as preparation method and application thereof

A sea cucumber polysaccharide and composition technology, applied in the field of medicine, can solve the problems of limited use effect and single strain

Active Publication Date: 2020-06-12
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, probiotic products have a single strain and cannot meet the needs of the complex flora system in the human intestinal tract, which limits their application to a certain extent; prebiotic products such as oligosaccharides have limited effects when used alone, and as carbohydrates, low Glycans can provide energy for the body after being metabolized, limiting the consumption of people with diabetes and obesity

Method used

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  • Sea cucumber polysaccharide composition as well as preparation method and application thereof
  • Sea cucumber polysaccharide composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A sea cucumber polysaccharide composition is prepared from the following raw materials in parts by weight: 200 g of sea cucumber, 100 g of mulberry leaves, 100 g of purslane, 50 g of gallinaceous gold and 50 g of malt; the preparation method comprises the following steps:

[0036]S1: Preparation of sea cucumber polysaccharide extract: Weigh sea cucumber, mulberry leaves and purslane according to weight ratio, mix them evenly and crush them into 300 meshes, add 8 times the mass of pure water at 80°C to extract 3 times, cool to room temperature Centrifuge at a speed of 3000r / min, discard the centrifuge and precipitate to obtain the supernatant, concentrate the supernatant at 60°C, add 5 times the mass of 80v / v% ethanol aqueous solution for precipitation, let stand for 48h, collect the precipitate and use Sephdex LH- 20 gel column chromatography for separation, followed by eluting with 20v / v%, 30v / v%, and 40v / v% methanol aqueous solution, combining the eluents and freeze-dr...

Embodiment 2

[0038] A sea cucumber polysaccharide composition is prepared from the following raw materials in parts by weight: 400 g of sea cucumber, 200 g of mulberry leaves, 200 g of purslane, 150 g of gallinaceous gold and 150 g of malt; the preparation method comprises the following steps:

[0039] S1: Preparation of sea cucumber polysaccharide extract: Weigh sea cucumber, mulberry leaf and purslane according to weight ratio, mix them evenly and crush them into 100 mesh, add 3 times the mass of pure water at 60°C for extraction once, cool to room temperature Centrifuge at a speed of 1000r / min, discard the centrifuge and precipitate to obtain the supernatant, after the supernatant is concentrated at 40°C, add 3 times its mass of 60v / v% ethanol aqueous solution for precipitation, let it stand for 24h, collect the precipitate and use Sephdex LH- 20 gel column chromatography for separation, followed by eluting with 20v / v%, 30v / v%, and 40v / v% methanol aqueous solution, combining the eluents ...

Embodiment 3

[0041] A sea cucumber polysaccharide composition is prepared from the following raw materials in parts by weight: 240g sea cucumber, 120g mulberry leaves, 120g purslane, 80g gallinaceous gold and 80g malt; the preparation method comprises the following steps:

[0042] S1: Preparation of sea cucumber polysaccharide extract: Weigh sea cucumber, mulberry leaves and purslane according to weight ratio, mix them evenly and crush them into 200 meshes, add 6 times the mass of pure water at 75°C for extraction twice, and cool to room temperature Centrifuge at a speed of 1500r / min, discard the centrifuge and precipitate to obtain the supernatant, concentrate the supernatant at 50°C, add 4.5 times the mass of 70v / v% ethanol aqueous solution for precipitation, let stand for 36h, collect the precipitate and use Sephdex LH- 20 gel column chromatography for separation, followed by eluting with 20v / v%, 30v / v%, and 40v / v% methanol aqueous solution, combining the eluents and freeze-drying to obt...

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Abstract

The invention discloses a sea cucumber polysaccharide composition. The composition is prepared from the following raw materials in parts by weight. The composition is prepared from, by weight, 200-400parts of sea cucumbers, 100-200 parts of folium mori, 100-200 parts of herba portulacae, 50-150 parts of endothelium corneum gigeriae galli and 50-150 parts of malt. The medicinal and edible traditional Chinese medicine components are used in a compatible mode, the treatment and health care effects of the traditional Chinese medicine components are brought into full play, the advantages of the traditional Chinese medicine components complement each other, gastrointestinal flora can be effectively adjusted, gastrointestinal mucosa can be effectively protected, the immunity can be improved, andthe composition has a good treatment effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a sea cucumber polysaccharide composition and a preparation method and application thereof. Background technique [0002] The human body carries approximately 3.9×10 13 bacteria, most of which reside in the gut. According to statistics, there are about 10 million non-repetitive genes in the human intestinal flora, which is about 150 times that of the human genome. Therefore, the metabolic capacity of intestinal flora far exceeds that of human cells. In addition, there is a significant correlation between the composition and abundance of intestinal flora and the function and metabolism of the human body. Disturbance of intestinal flora can easily increase the risk of insulin resistance, dyslipidemia, chronic inflammation, cancer and low immunity, leading to obesity, type 2 diabetes, non-alcoholic fatty liver and other metabolic syndromes. Therefore, regulating and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61P1/00A61P37/04A23L33/105A23L33/125A23L33/10A61K35/57A61K35/616
CPCA61K35/616A61K36/605A61K36/185A61K35/57A61K36/8998A61P1/00A61P37/04A23L33/105A23L33/125A23L33/10A61K2236/331A61K2236/39A61K2236/53A61K2236/55A61K2236/333A23V2002/00A61K2300/00A23V2200/32A23V2200/324A23V2300/14A23V2250/2042A23V2250/21A23V2250/204A23V2250/51A23V2250/51086A23V2250/5118A23V2250/51084
Inventor 王霞宿烽任屹清
Owner QINGDAO UNIV OF SCI & TECH