Application of kaempferol and its analogs

A technology of kaempferol and medicine, applied in the field of application of kaempferol and its analogues, to achieve the effects of enhancing the formation of venous blood vessels, strong practicability, cell proliferation and cell migration
CN111297848BActive Publication Date: 2021-05-14HKUST SHENZHEN RES INST
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HKUST SHENZHEN RES INST
Publication Date
2021-05-14

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Abstract

The application of kaempferol and its analogs is used for promoting angiogenesis by combining with vascular endothelial growth factor. The invention proposes the new application of kaempferol and its analogues, and firstly invents the means of using kaempferol to promote the angiogenesis induced by vascular endothelial growth factor, which can significantly enhance the proliferation and cell migration of human umbilical vein endothelial cells. In animal models, kaempferol can significantly enhance zebrafish inferior intestinal vein angiogenesis, further clarified its role in promoting angiogenesis, and can be used for the prevention and treatment of ischemic heart disease. The application design of the kaempferol and the analog thereof of the present invention is scientific and practical.
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Description

technical field

[0001] The invention relates to the field of angiogenesis, in particular to the application of kaempferol and its analogues. Background technique

[0002] Angiogenesis is a complex process of generating new blood vessels by stimulating the budding of endothelial cells to form small blood vessel growth and collateral circulation in the surrounding tissue on the basis of the original vascular network. This process involves multiple steps such as the degradation of vascular endothelial extracellular matrix, migration of endothelial cells to the degraded matrix, proliferation, stretching, formation of tubular structures, and production of endothelial extracellular matrix membrane. It mainly includes: degradation of vascular basement membrane in the activation phase; Activation, proliferation, migration; reconstruction of new blood vessels and vascular network is a complex process involving a variety of cells and molecules. Angiogenesis is a complex process of co...

Claims

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