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Composition for treating dysmenorrhea by combining fumigation instrument

The technology of a composition and traditional Chinese medicine, which is applied in the field of preparation of nanoemulsion dispersions, can solve the problems of poor ability of volatile oil components to penetrate the skin, sticking to the skin, unsuitable for hot water dissolution and the like

Inactive Publication Date: 2020-07-10
LIAONING HUANREN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prescriptions of traditional Chinese medicine fumigation to treat dysmenorrhea, Aconitine and other ingredients are mostly used, and aconitine is used in it. Its decomposition products have a paralyzing effect on various peripheral and central nerves, and are active ingredients for pain relief. However, long-term use of aconitine will cause cause chronic poisoning
In addition, most fumigation medicines contain volatile oil components, which dissolve under the action of hot water, but the ability of volatile oil components to penetrate the skin is poor, and the skin surface has a heavy sticky feeling after the medicated bath; traditional medicated baths need to Drugs are put into hot water to disperse the drug effect, but many drugs have special properties and are not suitable for hot water dissolution. For example, Ophiopogon japonicus and Wulingzhi are sticky in nature, and they will also cause stickiness after being dissolved in water. There are many fluffs and small thorns on the surface of inulata, capillary, thorns, etc., and the small thorns float in the water in hot water and stick to the skin, which may even easily cause scratches and allergies

Method used

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  • Composition for treating dysmenorrhea by combining fumigation instrument
  • Composition for treating dysmenorrhea by combining fumigation instrument
  • Composition for treating dysmenorrhea by combining fumigation instrument

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] 1) Take 9g of red ginseng silk, crush it with a chopping machine, add 18g of steamed ginseng water for 3 minutes, grind it with a colloid mill for 40 minutes, squeeze and filter to obtain 23.6g of slurry, add 0.02ml of volatile oil to the slurry, and use dynamic ultra-high pressure micro-jet The homogenizer is processed to obtain the red ginseng nano dispersion liquid.

[0068] 2) Take 15g of ginger, crush it with a chopping machine for 3min, add 30g of purified water, grind it with a colloid mill for 30min, press, and filter to obtain 31.2g of slurry, which is processed by a dynamic ultra-high pressure micro-jet homogenizer to obtain ginger nano Dispersions.

[0069] 3) Take 9g of mugwort leaves, 6g of angelica, 6g of chuanxiong, 6g of cassia twig, 6g of fennel, 6g of peppercorns, and 6g of Cyperus Cyperi directly into high-temperature steam at 120°C to extract volatile oil (valve opening and closing degree 0.2%), extract for 6 hours, and collect Volatile oil, obtain ...

Embodiment 2

[0073] 1) Take 13g of red ginseng silk, crush it with a chopping machine for 4min, add 26g of steamed ginseng water, grind it with a colloid mill for 50min, squeeze and filter to obtain 24.7g of slurry, add 0.03ml of volatile oil to the slurry, and use dynamic ultra-high pressure micro jet The mass machine is processed to obtain the red ginseng nano-dispersion.

[0074] 2) Take 17g of ginger, crush it with a chopping machine for 3min, add 34g of purified water, grind it with a colloid mill for 35n, press, filter to obtain 32.1g of slurry, and process it with a dynamic ultra-high pressure micro-jet homogenizer to obtain a ginger nano-dispersion .

[0075] 3) Take 10 leaves of mugwort, 7g of angelica, 7g of chuanxiong, 7g of cassia twig, 7g of cumin, 7g of Zanthoxylum bungeanum, and 7g of Cyperus Cyperi directly into 100°C high-temperature steam to extract volatile oil (valve opening and closing degree 0.2%), extract for 8 hours, and collect Volatile oil, obtain 2.8ml of volati...

Embodiment 3

[0079] 1) Take 8g of red ginseng silk, crush it with a chopping machine for 2min, add 16g of steamed ginseng water, grind it with a colloid mill for 35min, press, and filter to obtain 23.8g of slurry, add 0.02ml of volatile oil to the slurry, and use dynamic ultra-high pressure micro jet The mass machine is processed to obtain the red ginseng nano-dispersion.

[0080] 2) Take 12g of ginger, crush it with a chopping machine for 3min, add 24g of purified water, grind it with a colloid mill for 29min, press, filter to obtain 30.8g of slurry, and process it with a dynamic ultra-high pressure micro-jet homogenizer to obtain a ginger nano-dispersion .

[0081] 3) Take 10 leaves of mugwort, 5g of angelica, 5g of chuanxiong, 5g of cassia twig, 5g of fennel, 5g of peppercorns, and 5g of Cyperus Cyperi directly into high-temperature steam at 105°C to extract volatile oil (valve opening and closing degree 0.2%), extract for 6 hours, and collect Volatile oil, obtain 2.5ml of volatile oil...

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Abstract

The invention relates to the field of traditional Chinese medicine extracts, and particularly relates to a composition for treating dysmenorrhea by combining a fumigation instrument. Aiming at the technical problem of treating dysmenorrhea by fumigation in the prior art, the composition is prepared from red ginseng, raw ginger, folium artemisiae argyi, radix angelicae sinensis, acanthopanax, rhizoma chuanxiong, red peony root, moutan bark, radix ophiopogonis, fructus evodiae, cassia twig, liquorice, fennel, pericarpium zanthoxyli, radix bupleuri, rhizoma cyperi, trogopterus dung, radix achyranthis bidentatae, rhizoma corydalis, caulis spatholobi and other medicines through extraction, squeezing, nano homogenization and other processes, and is a traditional Chinese medicine nano dispersionmedicated bath solution with a dysmenorrhea treatment effect. Aiming at the medicines such as radix ophiopogonis, trogopterus dung and folium artemisiae argyi which are not suitable for being added into a medicated bath, the medicines such as radix ophiopogonis, trogopterus dung and folium artemisiae argyi can be added into the medicated bath for treatment through a certain processing technology,the effective components of the medicines are reserved to the maximum extent, the application efficiency of the medicines is remarkably improved, the prepared nano-emulsion is stable in property, aromatic and comfortable, and the use compliance of a patient is greatly improved.

Description

technical field [0001] The invention relates to the field of plant extracts, in particular to a preparation method and application of a nanoemulsion dispersion used in combination with a traditional Chinese medicine fumigation apparatus for treating dysmenorrhea. Background technique [0002] Dysmenorrhea, also known as menstrual pain, is one of the common clinical diseases of gynecological diseases. Periodic dysmenorrhea mainly occurs in women's menstrual cycle. The clinical manifestations are abdominal cramps accompanied by lower back pain, headache, nausea, vomiting or diarrhea. Medication can produce side effects and cause damage to the patient's body. Dysmenorrhea belongs to the category of "abdominal pain during menstruation" in my country's traditional Chinese medicine, and the lesion is located in the Chongren uterus. The cause of the disease is that the chongren meridian is not smooth due to the influence of various factors on the patient, qi stagnation and blood ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/107A61K9/06A61K9/00A61P15/00A61K35/24
CPCA61K9/0004A61K9/0014A61K9/06A61K9/1075A61K35/24A61K36/21A61K36/232A61K36/233A61K36/235A61K36/236A61K36/254A61K36/258A61K36/282A61K36/484A61K36/486A61K36/54A61K36/65A61K36/66A61K36/71A61K36/754A61K36/758A61K36/8905A61K36/8968A61K36/9068A61K47/32A61K2236/31A61K2236/331A61K2236/39A61K2236/51A61P15/00A61K2300/00
Inventor 郑继宇马振元周书繁苑鹏翀杨玉汪巍李国栋
Owner LIAONING HUANREN PHARMA