A magnetic microsphere with functional groups on its surface, its preparation method and application

A functional group, magnetic microsphere technology, applied in the field of material chemical industry, can solve the problems of magnetic flux leakage, uneven surface hydrophilicity and hydrophobicity, good consistency, high magnetic content, and achieve rich surface functional groups, good consistency, magnetic high content effect

Active Publication Date: 2022-02-22
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a magnetic microsphere with a functional group on the surface and its preparation method and application, the method comprising surface modification of the polymer microsphere to obtain a modified microsphere, and preparing the surface with For magnetic nanoparticles with functional groups, the two are dispersed and mixed in a solvent, and the pH of the solution is adjusted so that the surface of the modified microsphere and the magnetic nanoparticle have opposite charges, and the magnetic nanoparticle is adsorbed on the surface of the modified microsphere to form a composite microsphere. Afterwards, the composite microsphere is used as the core and the functional monomer forms a polymer layer with functional groups on the surface of the composite microsphere in the presence of a surfactant to obtain the magnetic microsphere. The method of the present invention effectively solves the problem of traditional Due to the problems of magnetic flux leakage and uneven surface hydrophilicity and hydrophobicity in the preparation process of magnetic microspheres, the obtained magnetic microspheres have uniform particle size, high magnetic content and good consistency, and rich surface functional groups

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  • A magnetic microsphere with functional groups on its surface, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0088] Preparation method of magnetic microspheres:

[0089] (1) Polystyrene microspheres were prepared by soap-free emulsion polymerization, and the specific synthesis method was as follows:

[0090] (a) Add 500mL of deionized water and 50mL of styrene into a 1L three-necked flask, and stir for 10 minutes under nitrogen at room temperature at a speed of 200r / min;

[0091] (b) Add 1.0 g of potassium persulfate to 50 ml of deionized water, and ultrasonically dissolve;

[0092] (c) Pour the potassium persulfate solution in step (b) into the solution in (a), heat up to 80° C., stir for 24 hours, and rotate at a speed of 200 r / min to obtain polystyrene microspheres;

[0093] The particle size of the prepared polystyrene microspheres is about 700 nanometers;

[0094] (II) carrying out nitration reaction on the surface of the polymer microspheres prepared in step (I), specifically comprising the following steps:

[0095] (a') 95% concentrated sulfuric acid of 900g and 65% concent...

Embodiment 2

[0106] The difference between this embodiment and Example 1 is that in step (Ⅲ), the sodium citrate solution is replaced with an equal volume of polyethylene glycol solution (polyethylene glycol in the polyethylene glycol solution is mixed with the above sodium citrate solution). The molar weight of the sodium citrate is identical), other conditions are compared with embodiment 1 and are exactly the same.

Embodiment 3

[0108] The difference between this embodiment and embodiment 1 is that the equimolar amount of methacrylic acid in step (V) is replaced by ethyl acrylate, and other conditions are completely the same as in embodiment 1.

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Abstract

The present invention relates to a magnetic microsphere with functional groups on the surface and its preparation method and application. The method comprises surface modification of polymer microspheres to obtain modified microspheres, and preparation of magnetic microspheres with functional groups on the surface. The magnetic nanoparticles are dispersed and mixed in the solvent, and the pH of the solution is adjusted so that the surface of the modified microsphere and the magnetic nanoparticle are oppositely charged, and the magnetic nanoparticle is adsorbed on the surface of the modified microsphere to form a composite microsphere, and then composite The microsphere is the nucleus. In the presence of the surfactant, the functional monomer forms a polymer layer with functional groups on the surface of the composite microsphere to obtain the magnetic microsphere. The method of the present invention effectively solves the problem of traditional magnetic microspheres. Due to the problems of magnetic flux leakage and uneven surface hydrophilicity and hydrophobicity in the preparation process, the obtained magnetic microspheres have uniform particle size, high magnetic content and good consistency, and rich surface functional groups.

Description

technical field [0001] The invention belongs to the field of material chemical industry, and relates to a magnetic microsphere with functional groups on the surface, a preparation method and application thereof. Background technique [0002] As a new type of nanomaterial, magnetic microsphere is the most widely cited core raw material in the field of in vitro diagnostics. It is a spherical magnetic material with a particle size of several hundred nanometers to several microns combined by inorganic magnetic materials and organic polymers. On the one hand, functional groups can be introduced on the surface, coupled with antibodies, antigens or other biomolecules, and the quantitative analysis of the target can be achieved through immune reaction and high-sensitivity detection methods; on the other hand, because the magnetic microspheres have a convenient magnetic field Manipulating characteristics, so when using magnetic microspheres as the carrier instead of traditional multi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F257/02C08F265/04C08F220/06C08F8/30C08F112/08C08F120/14C08K9/04C08K3/22B01J13/14G01N33/543C07K1/14C12N5/00
CPCC08F257/02C08F265/04C08F8/30C08K9/04C08K9/08C08K3/22B01J13/14G01N33/54326C07K1/14C12N5/00C08K2201/01C08K2201/011C08K2003/2275C08K2003/2272
Inventor 杨良嵘于杰淼刘会洲
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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