A New Efficient and Dynamic Synthesis and Purification Technology of N-Methylimidazole

Abstract

The invention provides a new technology for the synthesis and purification of highly efficient and dynamic N-methylimidazole, adding methylamine, formaldehyde, ammonia water and glyoxal solution into a reaction kettle to react to obtain a crude product containing N-methylimidazole; into the distillation condensing system, the distilled product is condensed and recovered into the condensation collection tank; the crude product in the condensation collection tank flows into the rectification raw material tank, and the raw material tank is connected to the rectification tower for rectification, and the raw material concentration and N-methyl The concentration of the imidazole product is adjusted dynamically to adjust the operating conditions of the refining system, and the concentration of the obtained N-methylimidazole product is above 99%. The present invention improves and upgrades the traditional process, and has the characteristics of short process and simple process. Especially, in the refining system, the operating parameters are dynamically adjusted according to the product concentration, which not only reduces energy consumption, but also improves the purity of N-methylimidazole. The obtained N-methylimidazole can be used in fields such as pharmaceutical synthesis, ionic liquid synthesis, curing agent for epoxy resin and other resins.

Description

technical field [0001] The invention relates to the technical field of synthesis and purification technology, in particular to a new high-efficiency dynamic N-methylimidazole purification technology. Background technique [0002] N-Methylimidazole (scientific name: 1-Methylimidazole) Alias: 1-methyl-1H-imidazole, 1-methylimidazole, colorless to light yellow transparent liquid, mainly used for the synthesis of conventional imidazole ionic liquids, can also be used Curing agent for epoxy resins and other resins, and intermediates for organic synthesis. [0003] Ionic liquid is a new type of green and environmentally friendly solvent composed of anions and cations. It has many properties different from conventional solvents, such as non-volatile, wide liquid range, good thermal stability, strong solubility, and wide electrochemical window. In recent years, ionic liquids have been widely used in the fields of catalysis and separation, organic synthesis, material preparation, re...

AI Technical Summary

Problems solved by technology

The imidazole substitution method has high energy consumption, a large amount of sewage, and the use of expensive and toxic methyl iodide. Therefore, most of the current one-step ring methods are used to produce N-methylimidazole

However, the existing one-step ring production process also has problems such as complicated purification and serious pollution.

Both patents CN110343071A and CN103086978 use imidazole and methanol to synthesize N-methylimidazole, and use a catalyst for the reaction. The energy consumption of the reaction is high, and the production of imidazole is not conducive to the large-scale preparation of N-methylimidazole

Patent CN105348199 uses organic solvents for extraction, which does not conform to the concept of clean and green development and the process is complicated

In the patent CN105732508A, gas-phase catalytic reaction is used to prepare N-methylimidazole, which speeds up the reaction speed, but the risk of reaction also increases

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