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Integrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization

A technology of mineral and mineral content, applied in the field of tendon/ligament stents, can solve the problem of inability to simulate the natural tendon-bone junction mineralization to non-mineralization gradient structure, etc., and achieves fine woven structure, high strength and good sports feeling. Effect

Active Publication Date: 2020-07-28
深圳市迈捷生命科学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, a challenging question is raised: repairs require strength and elasticity to accommodate the forces of activities of daily living and avoid elongation or fracture of the repaired site
[0005] CN 208481528U discloses a hybrid artificial ligament, but its ligament material is only composed of biodegradable and non-degradable two parts, which cannot simulate the mineralization of natural tendon-bone junction to non-mineralization gradient structure

Method used

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  • Integrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization
  • Integrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization
  • Integrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization

Examples

Experimental program
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Embodiment 1

[0053] (1) Extraction of silk fibroin: Weigh 60g silkworm cocoons and cut them into several layers, put them into 0.5% sodium bicarbonate aqueous solution and boil for 30 minutes, repeat twice to remove surface sericin, fully wash with deionized water, and dry in the air. Obtain silk fibroin fibers. Place silk fibroin fibers in CaCl 2 / H 2 O / absolute ethanol (molar ratio: 1:8:2) ternary solvent, heated to 70°C to dissolve for 40 minutes, then put into a dialysis bag with a molecular weight cut-off of 14000Da and dialyzed at room temperature for 7 days, and filtered the solution to obtain pure The silk fibroin aqueous solution is freeze-dried to obtain spongy silk fibroin.

[0054] (2) Preparation of spinning solution: Weigh 0.6g of P(LLA-CL) (75:25) with a molecular weight of about 200,000 (purchased from Jinan Daigang Biotechnology Co., Ltd.) and 0.2g of silk fibroin in 10mL Hexafluoroisopropanol (purchased from Shanghai Darui Fine Chemicals Co., Ltd.) was prepared into PL...

Embodiment 2

[0060] (1) Preparation of a mineralized to non-mineralized gradient structural integrated scaffold: PPS-0% HA nanofiber yarns are used as warp yarns, and PLA-PLCL / SF / HA nanofiber yarns loaded with different mineral contents are used as weft yarns, The weft thread in the middle part of the bracket is PLA-PLCL / SF yarn with zero mineral content, and the PPS-5%HA, PPS-10%HA, PPS-15%HA nanofiber yarn is used as the weft thread in the middle to both ends. The nanofiber yarns in warp and weft directions are interwoven by a weaving method to prepare a mineralized to non-mineralized gradient structural integrated scaffold.

[0061] (2) The weaving process of the above steps (1) is: on the semi-automatic weaving machine, use PPS-0% HA nanofiber yarn as the warp, and the distance between the two warps is 0.5~2mm. 10 warp threads; PPS-0% HA is used as the weft thread in the middle of the bracket, and PPS-5% HA, PPS-10% HA, and PPS-15% HA are used as the weft thread in sequence from the mi...

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Abstract

The invention relates to an integrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization, warps are nanofiber yarns with zero mineral content, weftsin the middle of the scaffold are nanofiber yarns with zero mineral content, and wefts from the middle to two ends are nanofiber yarns with gradually increased loaded mineral content. The constructedintegrated scaffold for simulating gradient structure from bone-tendon-bone mineralization to non-mineralization provides an ideal microenvironment for repairing tendon defects, realizes guiding of tendon tissue regeneration after implantation, promotes tendon-bone healing, and is very suitable for tendon-bone injury repairing.

Description

technical field [0001] The invention belongs to the field of tendon / ligament brackets, in particular to an integrated bracket for simulating bone-tendon-bone mineralization to non-mineralization gradient structure. Background technique [0002] Tendon / ligament (T / L) refers to a bundle of tough, regularly arranged connective tissue that connects muscle and bone, transfers force from muscle to bone, and enables joint function to achieve stability and movement. Because the stiffness of the tendon is between the muscle and the bone, it acts as an elastic buffer between the muscle and the bone. T / L injury is mainly caused by severe impact or frequent stretching under low intensity, including fracture, tear, degeneration or inflammation, and has become one of the most common injuries in the human body. Currently, the standard treatment for tendon repair requires surgical intervention, most commonly autografts, allografts, artificial prostheses and sutures, and subsequent rehabili...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/22A61L27/12A61L27/50A61L27/54A61L27/56A61L27/58D03D3/00D03D15/00D01D5/00D03D15/233D03D15/283D03D15/33D03D15/47
CPCA61L27/18A61L27/227A61L27/12A61L27/50A61L27/54A61L27/56A61L27/58D03D3/00D03D15/00D01D5/003D01D5/0092A61L2430/10A61L2400/12A61L2300/412A61L2300/41A61L2300/424A61L2300/414D03D15/47C08L67/04C08L89/00
Inventor 莫秀梅谢宪瑞
Owner 深圳市迈捷生命科学有限公司
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