Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefadroxil dispersible tablets and preparation method therefor

A technology for cefadroxil dispersible tablets and cefadroxil, which is applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of long production cycle, degradation risk of cefadroxil, The problem of high energy consumption, to achieve the effect of easy operation, suitable for large-scale production, and uniform drug release

Inactive Publication Date: 2020-07-31
REYOUNG PHARMA
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the preparation process of cefadroxil dispersible tablets in the prior art is wet granulation, which has disadvantages such as long production cycle, high energy consumption, and risk of degradation of cefadroxil

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefadroxil dispersible tablets and preparation method therefor
  • Cefadroxil dispersible tablets and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The prescription composition of every 10000 tablets of preparations: cefadroxil 5000g, ordinary microcrystalline cellulose 1000g, lactose 220g, starch 550g, magnesium stearate 80g.

[0023] Preparation:

[0024] After the raw materials are all passed through a 30-mesh sieve, take cefadroxil, common type microcrystalline cellulose, lactose and starch according to the prescription amount, mix uniformly, then add magnesium stearate, and after mixing uniformly, obtain the mixed material, the mixed material The bulk density is 0.5g / cm 3 , tap density 0.8g / cm 3 , after passing the test, the mixed material is compressed into tablets by a tablet machine to obtain cefadroxil dispersible tablets, and the hardness of the tablet is 110N.

Embodiment 2

[0026] The prescription composition of every 10000 preparations: cefadroxil 5000g, microcrystalline cellulose (PH101) 1110g, mannitol 190g, carboxymethyl starch sodium 500g, magnesium stearate 60g.

[0027] Preparation:

[0028] After the raw materials are all passed through a 30-mesh sieve, take cefadroxil, microcrystalline cellulose PH101, mannitol and carboxymethyl starch sodium according to the prescription amount, mix them uniformly, then add magnesium stearate, and mix them uniformly to obtain the mixed material. The bulk density of the material is 0.5g / cm 3 , tap density 0.9g / cm 3 , after passing the test, the mixed material is compressed into tablets by a tablet machine to obtain cefadroxil dispersible tablets, and the hardness of the tablet is 120N.

Embodiment 3

[0030] The prescription composition of every 10000 preparations: cefadroxil 5000g, microcrystalline cellulose (PH102) 1100g, starch 220g, carboxymethyl starch sodium 500g, magnesium stearate 30g.

[0031] Preparation:

[0032] After the raw materials are all passed through a 30-mesh sieve, take cefadroxil, microcrystalline cellulose PH102, starch and carboxymethyl starch sodium according to the prescription quantity, mix uniformly, then add magnesium stearate, after mixing uniformly, obtain the mixed material, mix The bulk density of the material is 0.6g / cm 3 , tap density 0.9g / cm 3 , after passing the test, the mixed material is compressed into tablets by a tablet machine to obtain cefadroxil dispersible tablets, and the hardness of the tablet is 110N.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
bulk densityaaaaaaaaaa
densityaaaaaaaaaa
hardnessaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of pharmaceutical preparations and particularly relates to cefadroxil dispersible tablets and a preparation method therefor. A prescription for the cefadroxil dispersible tablets per 10,000 tablets comprises the following ingredients by weight: 5,000g of cefadroxil, 1,000g-1,300g of filler, 500g-800g of disintegrant and 20g-100g of magnesium stearate. The preparation method comprises the steps of weighing the cefadroxil, the filler and the disintegrant according to prescription amounts, carrying out uniform mixing, then, adding the lubricant, i.e.,magnesium stearate, carrying out uniform mixing, then, carrying out tabletting by a tabletting machine, thereby obtaining the cefadroxil dispersible tablets. The cefadroxil dispersible tablets prepared by the preparation method are uniform in unit-time drug release, readily available in raw materials and controllable in quality. According to the preparation method, the cefadroxil dispersible tablets are produced by employing a mixed-powder direct-tabletting process, the process is simple, the quality is stable, the operation is easy, the method is applicable to large-scale production, and therisk of degradation of the cefadroxil is avoided.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a cefadroxil dispersible tablet and a preparation method thereof. Background technique [0002] Cefadroxil dispersible tablets not only have the characteristics of easy portability, storage and good stability of ordinary tablets, but also have the advantages of convenient administration of granules and syrups, good absorption and high bioavailability. To enhance the use effect of cefadroxil and expand the user population. Cefadroxil is a broad-spectrum semi-synthetic antibiotic of the cephalosporin class. This product has the characteristics of good oral absorption, little effect on food, high blood concentration, long effective concentration time, and low incidence of adverse reactions. This product has a good effect on penicillinase-producing and non-penicillinase-producing Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumon...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/26A61K31/545A61P31/04
CPCA61K9/2018A61K9/2054A61K9/2095A61K31/545A61P31/04
Inventor 苗得足黄京山李伟陈德仁
Owner REYOUNG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com