Method for preparing linarin micro-capsule particles

A technology of microcapsules and fenugreek, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of oxidative degradation, drug efficacy reduction, etc., and achieve the goal of enhancing anti-oxidation, improving solubility, and improving compactness Effect

Inactive Publication Date: 2020-08-07
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Menghuaside dry powder is not protected by other media, and it is easy to oxidize and degrade under the action of light, high temperature and oxygen, resulting in a decrease in drug efficacy.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A method for preparing Menghuaside microcapsule particles, comprising the steps of:

[0025] (1) Dissolve mongoside in 10 times the weight of water, then add mongoside with 3.5% tea saponin and 5% lactic acid fatty acid glyceride, heat to 70°C, stir to dissolve completely and evenly, and obtain the core material solution;

[0026] (2) Use phlorizin, rhamnolipid and gum arabic at a mass ratio of 2:3:15 as the wall material, add water 12 times the weight of the wall material, stir evenly, and heat up to 70°C to obtain a capsule material solution ;

[0027] (3) Add the core material solution to the capsule material solution while it is hot and add it to the homogenizer according to the mass ratio of 1:3, and homogenize for 3 times at a pressure of 40 MPa, each time for 30 minutes, to obtain a mixed solution;

[0028] (4) Send the mixed solution to a granulation sprayer for spray drying to a moisture content of 4.3%, and then cool to room temperature to obtain fenugreek m...

Embodiment 2

[0032] A method for preparing Menghuaside microcapsule particles, comprising the steps of:

[0033] (1) Dissolve Menghuaside in 8 times the weight of water, then add Menghuaside with 2% tea saponin and 6% lactic acid fatty acid glyceride, heat to 65°C, stir to dissolve completely and evenly, and get the core material solution;

[0034] (2) Use phlorizin, rhamnolipid and gum arabic with a mass ratio of 1:4:10 as the wall material, add water 10 times the weight of the wall material, stir evenly, and heat up to 70°C to obtain a capsule material solution ;

[0035] (3) Add the core material solution to the capsule material solution while it is hot, add it to the homogenizer at a mass ratio of 1:2, and homogenize twice under a pressure of 50 MPa, each time for 30 minutes, to obtain a mixed solution;

[0036] (4) Send the mixed solution to a granulation sprayer for spray drying to a moisture content of 4.6%, and cool it to room temperature to obtain sagerin microcapsules. The spr...

Embodiment 3

[0039] A method for preparing Menghuaside microcapsule particles, comprising the steps of:

[0040] (1) Dissolve Menghuaside in 10 times the weight of water, then add Menghuaside with 4% tea saponin and 5% lactic acid fatty acid glyceride, heat to 70°C, stir to dissolve completely and evenly, and obtain the core material solution;

[0041] (2) Use phlorizin, rhamnolipid and gum arabic at a mass ratio of 3:5:20 as the wall material, add water 14 times the weight of the wall material, stir evenly, and heat up to 65°C to obtain a capsule material solution ;

[0042] (3) Add the core material solution to the capsule material solution while it is hot, add it to the homogenizer at a mass ratio of 1:1, and homogenize for 3 times under a pressure of 60 MPa, each time for 20 minutes, to obtain a mixed solution;

[0043] (4) Send the mixed solution to a granulation sprayer for spray drying to a moisture content of 4.8%, and then cool to room temperature to obtain the microcapsule gran...

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PUM

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Abstract

The invention discloses a method for preparing linarin micro-capsule particles. The method comprises the following steps: dissolving linarin in water with the weight being 8-10 times that of linarin,adding tea saponin and lactic acid fatty glyceride, and uniformly stirring to obtain a core material solution; taking phlorizin, rhamnolipid and Arabic gum as wall materials, adding water of which theweight is 10-15 times that of the wall materials, performing uniform stirring, and heating to 60-70 DEG C so as to obtain a capsule material solution; adding the core material solution into the capsule material solution according to a mass ratio of 1:(1-4), adding into a homogenizer, and homogenizing to obtain a mixed solution; and sending the mixed solution into a granulation sprayer, performingspray drying, and cooling to room temperature to obtain the linarin microcapsule particles. According to the method disclosed by the invention, the linarin is microencapsulated by selecting the proper core material and the wall materials, so that the efficient encapsulation of the linarin can be effectively realized, the solubility is improved, the stability is improved, the storage period is prolonged, and the adhesive capacity of the microcapsules in the stomach of a human body is effectively improved; and the antioxidant, hypoglycemic and anti-inflammatory effects and the like of the linarin microcapsules can be enhanced, the medicine flavor is masked, and the sweetness of the linarin microcapsules is improved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a method for preparing mongoside microcapsules. Background technique [0002] Buddleja officinalis Maxim is the dry flower bud and inflorescence of Buddleja officinalis Maxim. It is sweet in taste, slightly cold in nature, and returns to the liver and gallbladder meridians. It has the effects of dispelling wind and clearing heat, nourishing the liver and improving eyesight, and reducing nebula. Dim vision embolism. Clinically, it is mainly used for eye diseases such as dry eye syndrome, diabetic retinopathy, and conjunctivitis, and the curative effect is remarkable. [0003] One of the main medicinal ingredients of Budisma japonica is mongoside, which is composed of acaciacetin and an aglycone, and exists in the form of two isomers, the α body and the β body at the same time. It is the most active of many flavonoids one of the compounds. Meng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36A61K47/26A61K31/7048A61K31/7034A61K31/704A61P39/06A61P3/10A61P29/00A61P25/00A61P35/00
CPCA61K9/5015A61K9/5036A61K31/7034A61K31/704A61K31/7048A61P3/10A61P25/00A61P29/00A61P35/00A61P39/06A61K2300/00
Inventor 黄锁义周世友卢丽香陈石梅雷智冬钟兆银
Owner 右江民族医学院
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