Application of nitazoxanide in preparation of medicines, foods or daily necessities for preventing and treating decayed teeth and disinfecting oral cavity

A technology for nitazoxanide and oral disinfection, which is applied in the function, application, and oral care of food ingredients to achieve the effects of promoting aggregation, good antibacterial effect, assisting dental caries treatment and preventing dental caries.

Pending Publication Date: 2020-08-07
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although nitazoxanide is a marketed drug, it has never been report...

Method used

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  • Application of nitazoxanide in preparation of medicines, foods or daily necessities for preventing and treating decayed teeth and disinfecting oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of preparation for the preparation of medicine for preventing and treating dental caries:

[0026] The sucrose (18.55g), nitazoxanide (1.2g), sodium benzoate (110mg), xanthan gum (62mg), microcrystalline cellulose / sodium carboxymethyl cellulose (520mg) that take by weighing prescription quantity mix, and then Add the prescribed amount of anhydrous citric acid (130mg), sodium citrate (33mg), strawberry flavor essence (85mg), and allura red aluminum lake (10mg) and mix well to obtain nitazoxanide dry suspension.

[0027] (1) In vitro inhibitory effect test of nitazoxanide on Streptococcus mutans:

[0028] Nitazoxanide is dissolved in the liquid culture medium by doubling dilution method to prepare different concentrations of medicinal solutions. Draw 20 μL of the corresponding drug solution for each drug concentration and add it to the sterilized 96-well plate, take 180 μL of the bacterial solution dropwise to each well, and set up a well where only 200 μL of the ...

Embodiment 2

[0035] Preparation of toothpaste containing nitazoxanide:

[0036] The toothpaste containing nitazoxanide is made up of the raw material of following parts by weight: nitazoxanide (0.01%), 21 parts of calcium carbonate, 9 parts of glycerin, 0.9 part of sodium carboxymethylcellulose, 5 parts of sorbitol, dodecane 1 part of sodium phenylsulfonate, 0.1 part of xylitol, 0.4 part of mint oil, sodium fluoride (0.1%), and 13 parts of water. Weigh each ingredient according to the composition. Pre-disperse sodium carboxymethyl cellulose in glycerin to obtain glycerin gum, then add sorbitol and a small amount of water into the beaker, and stir until uniform and transparent without particles. Stir for half an hour at a temperature of 50-70°C. The remaining water was added to the beaker and stirred for 10 min. Add nitazoxanide, sodium fluoride, calcium carbonate, and sodium dodecylbenzenesulfonate into the beaker, and stir for 5 minutes. Add xylitol, peppermint oil and stir for 30min ...

Embodiment 3

[0038] Preparation of mouthwash containing nitazoxanide:

[0039]The toothpaste containing nitazoxanide is composed of the following raw materials in parts by weight: nitazoxanide (0.01%), 10 parts of sorbitol, 10 parts of edible alcohol, 0.05 parts of aspartame, 0.05 parts of acesulfame, monofluorophosphoric acid 0.01 part of sodium, 0.1 part of sodium benzoate, 0.05 part of essence, 0.03 part of menthol, appropriate amount of water. First disperse sorbitol, edible alcohol, aspartame, acesulfame potassium, and sodium monofluorophosphate with water, and then completely dissolve the essence, sodium benzoate, and menthol; under stirring (stirring speed 50 rpm), Mix the two phases and stir for 10-20 minutes; when the two phases are evenly mixed, add nitazoxanide and continue to stir. After all the materials are mixed evenly, stop stirring; The finished product of Zoxanite mouthwash.

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Abstract

The invention relates to an application of nitazoxanide in preparation of medicines, foods or daily necessities for preventing and treating decayed teeth and disinfecting oral cavities, and belongs tothe technical field of new application of medicines. The invention discloses the application of nitazoxanide in preparing medicines, foods or daily necessities for preventing and treating decayed teeth. The nitazoxanide is streptococcus mutans. The invention also discloses an application of nitazoxanide in preparation of medicines, foods or daily necessities for oral disinfection. The types of the viruses inhibited by the nitazoxanide are coronaviruses including novel coronaviruses, influenza viruses, hepatitis viruses and HIV viruses. According to the invention, detailed research on inhibition of streptococcus mutans by nitazoxanide is carried out, the types of decayed tooth prevention and treatment and oral cavity disinfection are expanded, and the new application of known medicines isalso expanded.

Description

technical field [0001] The invention relates to the application of nitazoxanide in the preparation of medicines, food or daily necessities for the prevention and treatment of dental caries and oral disinfection, and belongs to the new application technical field of medicine. Background technique [0002] Dental caries is a bacterial infectious disease, a common and frequently-occurring disease of human beings, and the third disease that requires key prevention and treatment after cardiovascular disease and cancer. 60% to 90% of children and adults in the world have been affected by it. The problem of dental caries. Bacterial morphology in the human oral cavity is extremely complex, but Streptococcus mutans has been considered the main cause of dental caries. Streptococcus mutans firmly adheres to tooth surfaces and contributes to plaque biofilm formation by producing glucosyltransferases from sucrose and synthesizing water-insoluble glucans. Plaque biofilm cannot be rinsed...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61P1/02A61P31/04A61P31/14A61P31/16A61P1/16A61P31/20A61P31/18A61K8/49A61Q11/00A61Q17/00A23G4/12A23G4/06
CPCA61K31/426A61P1/02A61P31/04A61P31/14A61P31/16A61P1/16A61P31/20A61P31/18A61K8/49A61Q11/00A61Q17/005A23G4/12A23G4/06A23V2002/00A23V2200/312A23V2250/30
Inventor 苗得足胡清文王向华杨书华刘德杰李相林胡伟
Owner REYOUNG PHARMA
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