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Microcatheter and its preparation method and medical device including same

A technology of micro-catheter and tube body, applied in the direction of catheter, biocide-containing paint, coating, etc., can solve the problems of insufficient cross-linking degree, accompanied by peculiar smell, easy migration of fragments, etc.

Active Publication Date: 2021-06-08
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no effective cross-linking components are added to the composition, which easily leads to insufficient cross-linking and weak coating. At the same time, the system only uses small molecule photoinitiators, which easily leads to problems with odor and easy migration of fragments. problems, reduce the biological safety of the coating, and affect the overall performance

Method used

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  • Microcatheter and its preparation method and medical device including same
  • Microcatheter and its preparation method and medical device including same
  • Microcatheter and its preparation method and medical device including same

Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach

[0051] In the first embodiment of the present invention, a microcatheter is provided, which is characterized by comprising: a tube body and a coating formed on the surface of the tube body, the coating is formed from a coating composition, and the coating The layer composition comprises at least one photosensitive ionic liquid compound and at least one photocurable polymer, wherein,

[0052] The structure of the photosensitive ionic liquid compound includes a photosensitive structural part and a quaternary ammonium salt structural part;

[0053] The photocurable polymer is formed by copolymerization of components including a water-soluble polymerizable photosensitive monomer and a hydrophilic monomer,

[0054] The water-soluble polymerizable photosensitive monomer contains: 1) a unit containing a photosensitive structure; 2) a unit containing a quaternary ammonium salt structure; 3) a unit containing an unsaturated bond structure;

[0055] The unit containing the photosensiti...

no. 2 approach

[0120] In a second embodiment of the present invention, a medical device is provided, which includes the above-mentioned microcatheter with a coating formed on its surface.

[0121] The coated microcatheters can be inserted into various living tissues and physiological solutions containing mediators. Examples of such tissues include mucous membranes such as the urethra, blood vessels, heart, kidneys, lungs, throat, eyes. The present invention provides medical devices that are lubricious to the touch, allowing easy insertion into bodily tissues or cavities, and retaining hydrophilicity, lubricity, and antibacterial / bactericidal properties over a prolonged period of time in contact with tissues, such as mucous membranes , and the product is easily taken out, rubbed repeatedly 30 times in a simulated human tissue environment, the coating does not fall off, the lubricity does not decrease, and the firmness is excellent.

[0122] "Medical device" in the present invention should be...

Embodiment

[0124] The following examples are given to illustrate the present invention, and those skilled in the art can understand that the examples are only exemplary descriptions, not exhaustive descriptions.

[0125]

[0126] Weigh 2.0 g of the compound represented by formula (b), and dissolve it in a mixed solution of 20 mL of chloroform and 2 mL of triethylamine. Then, a 2M solution of 4-benzoylbenzoyl chloride in dichloromethane was added dropwise under ice-bath conditions, and after the dropwise addition was completed, the mixture was reacted overnight at room temperature, and the compound represented by formula (a) was obtained after the reaction was completed.

[0127]

[0128]

[0129]

[0130] Weigh 22.4g (100mmol) 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, 10.6g (105mmol) triethylamine and dissolve in 100mL dichloromethane and place in a 250mL flask and placed in an ice-water bath to fully dissolve. 9.1 mL of bromoacetyl bromide (21.1 g, 105 mmol) in di...

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Abstract

The present invention relates to a microcatheter, a preparation method thereof and a medical device including the same, comprising: a tube body and a coating formed on the surface of the tube body, the coating is formed from a coating composition, and the coating The composition includes at least one photosensitive ionic liquid compound and at least one photocurable polymer. The microcatheter of the present invention not only obtains a good and long-lasting antibacterial effect during use, but also enables the surface coating to adhere firmly and have good lubricity.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to the field of microcatheters with a hydrophilic lubricating coating. Background technique [0002] Microcatheters play a very important role in the delivery of diagnostic agents, therapeutic agents or devices, and interventional treatment of diseases. In the process of disease intervention, doctors usually need to use microcatheters to improve the operability of the guide wire, improve the support and passability of the guide wire, such as the treatment of complex coronary lesions such as chronic total occlusion lesions and bifurcation lesions. The material of the microcatheter is mainly composed of metal and polymer, and the lubricating effect of the surface of the microcatheter of these materials is generally poor, and it is easy to cause damage to the surrounding tissue during the insertion or extraction process. In addition, bacteria are easily introduced during the operation o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M25/00C09D5/14C09D139/06
CPCA61M25/0045A61M2025/0046A61M2025/0056C09D5/14C09D139/06A61L29/00A61M25/00
Inventor 李业
Owner JIANGSU BIOSURF BIOTECH CO LTD
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