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Synthesis method of chiral copper sulfide superparticles

A synthetic method, copper sulfide technology, applied in the field of nanomaterials and self-assembly science, can solve the problem that chirality generates chiral signals and the interaction between chiral substances is poorly understood

Active Publication Date: 2020-08-11
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the preparation of chiral materials is relatively mature, little is known about the generation of chirality, the regulation of chiral signals, and the interaction between chiral substances.

Method used

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  • Synthesis method of chiral copper sulfide superparticles
  • Synthesis method of chiral copper sulfide superparticles
  • Synthesis method of chiral copper sulfide superparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 The synthesis and purification route of penicillamine-stabilized chiral cuprous sulfide nanoparticles is as follows:

[0022] (1) Synthesis of penicillamine-stabilized chiral cuprous sulfide nanoparticles: under argon, 50 mL of ultrapure water was first heated to 60 °C and maintained for 30 min to exclude oxygen, and then 0.67 mmol of Copper chloride dihydrate (CuCl 2 2H 2 O), after it is completely dissolved, add 0.83 mmol of sodium hydroxide (NaOH), and stir evenly. 0.83 mmol of sodium borohydride (NaBH 4 ), after the color of the solution turns purple, add 0.67 mmol of penicillamine (Pen) at the end, and the solution slowly turns brown. After the temperature rises steadily to 95°C and stirs for 30 minutes under reflux, slowly cool to room temperature, and continue to react overnight , when the solution turns purple again, the reaction is complete.

[0023] (2) Purification of nanoclusters: Add 6 times more volume of isopropanol solution, centrifuge at 1...

Embodiment 2

[0025] Example 2 The method of assembling chiral copper sulfide nanoparticles stabilized by penicillamine and tobacco mosaic virus capsid protein into chiral copper sulfide superparticles is as follows:

[0026] (1) Preparation of non-disc-shaped tobacco mosaic virus capsid protein: mix 1 mL of tobacco mosaic virus capsid protein (2.5 mg / mL) with dithiothreitol (DTT) or β-mercaptoethanol (10 μL , 1M) mixed, incubated at 30°C for 30min, and then purified by ultrafiltration through a 10KDa ultrafiltration tube (9000rpm, 10 min, three times); the transmission electron microscope image of the treated tobacco mosaic virus capsid protein is shown in Figure 6 shown;

[0027] (2) Self-assembly: The assembly of chiral copper sulfide superparticles is to first weigh 2 mg of the penicillamine-stabilized chiral cuprous sulfide nanocluster powder purified in Example 1 above, and dissolve it in 10 mL of ultrapure water At this point, take out 1mL of dissolved nanoclusters and mix them wit...

Embodiment 3

[0028] Example 3 Characterization of superparticles and nanoclusters

[0029] (1) Circular dichroism spectrum characterization is specifically as follows: take the purified chiral cuprous sulfide nanoclusters and chiral copper sulfide superparticle solution for circular dichroism spectrum test respectively, the scanning wavelength is 300-1000nm, and the scanning speed is 1s / 2nm, and the scan was stabilized at 25°C. At the same time, we obtained the circular dichroism spectrum of the buffer solution as a control;

[0030](2) X-ray crystallographic characterization is specifically as follows: After the dry powder of the original chiral cuprous sulfide nanoparticles is passed through a 300-mesh sieve, the copper target is used as the radiation source during the test. The scanning speed is 0.2 angles per second, and the scanning range is 5 degrees to 90 degrees;

[0031] (3) The electron microscope test is specifically as follows: take 5 times dilution of chiral cuprous sulfide...

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Abstract

The invention discloses a synthesis method of chiral copper sulfide superparticles, and belongs to the technical field of nanometer materials and self-assembly science. Penicillamine-stabilized chiralcuprous sulfide nanoclusters and tobacco mosaic virus capsid protein are subjected to self-assembly under the action of light to obtain cake-shaped chiral cuprous sulfide superparticles. The invention provides a light-operated preparation method of chiral copper sulphide superparticles, and the preparation method has important significance for developing more chiral materials and understanding the interaction between the chiral materials.

Description

technical field [0001] The invention relates to a method for synthesizing chiral copper sulfide superparticles, which belongs to the field of nanomaterials and self-assembly science and technology. Background technique [0002] Chirality is a measure of the symmetry of a substance, and a substance that cannot overlap its mirror image is a chiral substance. The first person to discover chirality and link it to optical activity was Louis Pasteur. Subsequently, scientists discovered that most biomolecules (proteins, nucleic acids, and sugars) are chiral, and also made amazing achievements in the enantioselective synthesis of small molecules by taking advantage of their chiral recognition. Chirality is ubiquitous in nature and is an important hallmark of life on Earth. All living organisms use almost exclusively L-amino acids and D-sugars as building blocks for proteins and nucleic acids. Chirality is observed in nature at almost all length scales. For example, chirality, or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G3/12B82Y30/00C07K14/08C07K1/34C08G83/00
CPCB82Y30/00C01G3/12C07K14/005C07K19/00C08G83/008C12N2770/00022
Inventor 胥传来高锐匡华徐丽广马伟刘丽强孙茂忠吴晓玲宋珊珊胡拥明郝昌龙
Owner JIANGNAN UNIV
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