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A kind of high acid-resistant vitamin A product and preparation method thereof

A vitamin and acetate technology, applied in pharmaceutical formulations, non-active components of polymer compounds, medical preparations of non-active components, etc., can solve the problems of high pressure and homogenization temperature, difficult industrialization, complicated processes, etc., and achieve acid resistance. The effect of improving the property and stability, increasing the product load and reducing the degree of degradation

Active Publication Date: 2022-08-05
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CN200710192023.7 discloses a method for preparing vitamin A and vitamin E nanosphere / microsphere double embedding system, using Tween-80 and monoglyceride as emulsifier, and octenyl succinic esterified starch as wall material , after high-speed shearing and high-pressure homogenization, vitamin A nanoemulsions were obtained, and then spray-dried to obtain finished products, but the high-pressure homogenization temperature was relatively high, and the spray-drying method adopted was not conducive to tablet production
[0007] A preparation method of vitamin E microcapsules is disclosed in CN20081024267.3. Soybean lecithin and Tween-80 are used as composite emulsifiers to obtain vitamin E microcapsule products through high-pressure emulsification and centrifugal spray drying. The emulsifier addition amount is 1.5 The dosage of %~1.75% is not allowed to be used in some countries and regions. At the same time, high-speed shearing and high-pressure homogenization are used many times. The complicated process is not conducive to industrial production
[0008] CN200880025234.4 discloses tabletable preparations of lipophilic health ingredients. In the production process of vitamin A tableted microcapsules, cornstarch needs to be cooled and sieved, and then dried at room temperature. The complex process is not conducive to industrial production
[0009] In view of the above various vitamin A microcapsule products, the preparation process is complicated, the industrialization is difficult, and the application characteristics are not clear. A new preparation method for vitamin A microcapsules is needed to better solve the above problems

Method used

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  • A kind of high acid-resistant vitamin A product and preparation method thereof
  • A kind of high acid-resistant vitamin A product and preparation method thereof
  • A kind of high acid-resistant vitamin A product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Water phase preparation: Arabic glue 40.4g and glide 14.8g of glueylin are dissolved in 100g of water, adding 0.4g of askthalotic acid and 1.2g of sodium ascorbicate.

[0041] Oil phase preparation: Vitamin A acetate 20.8g and BHT 2.4G are dissolved from light and stirring at 60-65 ° C.

[0042] After the two phases are mixed, the dispersed emulsification is fully stirred and the temperature is 60-65 ° C during the period to obtain an emulsion solution.

[0043] The analogenic liquid at 40 ± 2MPa is high.

[0044] Place the emulsification solution in the constant temperature tank, the control temperature is 60-65 ° C, spray drying, spray dry, and then fluidize and polish to obtain vitamin A acetate micro-capsule.

Embodiment 2

[0046]Water phase preparation: 38.2g of Arabic gel essence of ethyl amber, 15.2g of gloutic syrup is dissolved in 100g of water, adding 0.6g of askthalogenic acid and 0.8g of sodium ascorbicate.

[0047] Oil phase preparation: Vitamin A palmate 23.2g and BHT 2.0g are dissolved from light and stirring at 60-65 ° C.

[0048] After the two phases are mixed, the dispersed emulsification is fully stirred and the temperature is 60-65 ° C during the period to obtain an emulsion solution.

[0049] The analogy of emulsification at 50 ± 2MPa is high.

[0050] Place the emulsification solution in the constant temperature tank, the control temperature is 60-65 ° C, spray drying, spray dry, and then fluidize and polish to obtain vitamin A palmate micro-capsule.

Embodiment 3

[0052] Water phase preparation: 43.5g of Arabic gels in ethyl amber curl acid and 16.0g of gloud syrup is dissolved in 100g of water, adding 0.5g of askthalotic acid, and 1.5g of sodium ascorbicate.

[0053] Oil phase preparation: Vitamin A 15.5g and BHT 3.0G are dissolved from light and stirring at 60-65 ° C.

[0054] After the two phases are mixed, the dispersed emulsification is fully stirred and the temperature is 60-65 ° C during the period to obtain an emulsion solution.

[0055] High pressure on the emulsification solution at 30 ± 2MPa.

[0056] Place the emulsification solution in the constant temperature tank, the control temperature is 60-65 ° C, the spray is dry, the spray is dry, and then the vitamin A microcapsule is obtained by fluidization and polishing.

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PUM

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Abstract

The invention discloses a high acid-resistant vitamin A product and a preparation method thereof. The raw materials include, in parts by weight, 10-40 parts of vitamin A substances; 30-60 parts of embedded wall materials; and 5-35 parts of filling materials; 0-8 parts of antioxidants, wherein the vitamin A substance is selected from vitamin A, vitamin A acetate or palmitate. The invention overcomes the defects existing in the application of vitamin A raw materials, and the combined use of the preferred embedded wall material, filling material and antioxidant greatly improves the stability and acid resistance of the vitamin A ester microencapsulated product; The high-temperature melting and high-speed shearing process can effectively reduce the degree of degradation of the raw materials during processing, and achieve the effect of safety and environmental protection, and the preparation process is simple, which is conducive to industrial production.

Description

Technical field [0001] The present invention is a functional additive preparation technology field. Specifically designed a high -acid -resistant vitamin A product and its preparation methods. Background technique [0002] Vitamin A, also known as retinol or anti -eye drying factors, is a unsaturated one -dollar alcohol with a lipid ring. Its pure products are pale yellow crystals with a molecular weight of 286.46g / mol. Vitamin A is a fat -soluble vitamin, insoluble in glycerin and water, and is easily soluble in methane, ether, petroleum ether, water -free ethanol and vegetable oil. Vitamin A is an essential nutrient element for normal growth and development of the human body, skeletal formation, maintaining normal visual and immune systems. It has the functions of lipid -resistant peroxidation, enhanced immunity, enhances anti -infection, regulates fat storage, and improves iron deficiency anemia. Vitamin A deficiency will increase the incidence of various infectious diseases, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/42A61K47/26A61K47/36A61K47/10A61K31/07
CPCA61K9/5057A61K9/5015A61K9/5036A61K31/07
Inventor 马宇骥李倩陈碧聪耿佳鑫李晓贺吴文忠
Owner INNOBIO CORP LTD
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