A capsule for monitoring the pH value of gastric acid by nuclear magnetic resonance imaging and its preparation method

A nuclear magnetic resonance imaging and capsule technology, which is applied in the fields of capsule delivery, application, and pharmaceutical formulation, etc., can solve the problem of easy interference of amplification ability and pH value response ability, reduce the amplification effect of HSA-Mn system, and non-mono-responsiveness of pH and other problems, to achieve the effect of non-destructive monitoring of gastric acid pH, low production cost, and simple preparation method

Active Publication Date: 2022-03-15
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the MRI signal is very sensitive to the chemical environment and concentration profile of CAs, which alone may result in a non-mono-responsiveness to pH
Since there is no strong covalent bond, its amplification ability and pH value response ability are susceptible to interference
Certain molecules, especially those that chelate Mn(II) or bind to HSA, significantly reduce the amplification effect of the HSA-Mn system, making it unsuitable for use in the stomach alone

Method used

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  • A capsule for monitoring the pH value of gastric acid by nuclear magnetic resonance imaging and its preparation method
  • A capsule for monitoring the pH value of gastric acid by nuclear magnetic resonance imaging and its preparation method
  • A capsule for monitoring the pH value of gastric acid by nuclear magnetic resonance imaging and its preparation method

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preparation example Construction

[0111] The third aspect of the present invention provides a method for preparing the capsule shell, the method comprising the following steps:

[0112] 1) preparing a gel solution, heating the gel solution until clear and transparent;

[0113] 2) pouring the gel solution in step 1) into the capsule cavity of the mould, inserting the capsule core into the capsule cavity,

[0114] and / or,

[0115] The gel solution in step 1) is poured into the cap cavity of the mould;

[0116] 3) Leave it for a certain period of time until the gel is formed, then remove the gel from the mold to obtain the capsule shell;

[0117] In a preferred embodiment, the concentration of the gel solution in step 1) is 1-5% (mass percentage), for example, it may be 3%.

[0118] In step 1), the gel is heated until it is clear and transparent without air bubbles, which can ensure the uniformity of the prepared capsule shell.

[0119] In step 2), the heated gel solution needs to be quickly poured into the...

Embodiment 1

[0136] Example 1 HSA-Mn solution NMR signal amplification and pH responsiveness

[0137] In order to explore the nuclear magnetic signal amplification effect of HSA-Mn solution under specific detection conditions (magnetic field strength, temperature), different concentrations of HSA-Mn solutions were prepared, in which manganese ions were derived from manganese chloride (manufacturer: Aladdin Biochemical Technology Co., Ltd., Product number: M299158), the original concentration is 0.05M, that is, 2750mg / L, diluted with deionized water into two parts, A solution, the concentration is 100mg / L, and B solution, the concentration is 1000mg / L. HSA comes from Beijing Baishayi Technology Co., Ltd., product number BS027. The specific method of preparation is as follows:

[0138] 1) Mix manganese chloride and MOPS buffer according to Table 1. Each group prepares two solutions with different pH (pH=1 and pH=7), and the different pH is realized by the pH value of the MOPS buffer soluti...

Embodiment 2

[0151] The preparation of embodiment 2 hydrogel capsules

[0152] 1. Preparation of hydrogel capsule shell:

[0153] Combination mold: first put together the first template and the second template, screw 6 screws in, and lock the joint surface, such as figure 2 As shown, a complete capsule cavity is formed;

[0154] Gel pouring: heating 3% (mass percentage) agarose gel to 90 degrees Celsius to make the gel clear and transparent without bubbles, and quickly pour it into the capsule cavity;

[0155] Molding: press the third template figure 2 Insert it into the cavity of the capsule body as shown, place the mold at room temperature (25 degrees Celsius) for 5 minutes, and then transfer to an environment of 4 degrees Celsius for another 5 minutes;

[0156]Demoulding: Unscrew 6 screws, immerse the mold and the coagulated gel in water, slowly and carefully uncover the first template and the second template, and after the gel is filled and wet, remove the gel from the capsule of ...

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Abstract

The invention relates to the field of physiological index detection, in particular to a capsule for monitoring the pH value of gastric acid by nuclear magnetic resonance imaging and a preparation method thereof. The capsule includes a capsule shell and medicine placed in the capsule shell, and the capsule shell includes A capsule cap and a capsule body are connected, the capsule body is provided with a medicine containing cavity, and the capsule shell is made of gel. The capsule of the present application can be taken orally, and has strong drug compliance; it can eliminate the interference of macromolecules in gastric juice, and at the same time it will not excessively hinder the free entry and exit of hydrogen protons; it has a special structure and shows a different structural image from the surrounding tissue, which helps The signal is collected and the capsule is tracked in the body; the preparation method is simple and the production cost is low; the most important thing is that it can assist MRI to realize the non-destructive monitoring of gastric acid pH.

Description

technical field [0001] The invention relates to the field of physiological index detection, in particular to a capsule for monitoring the pH value of gastric acid by nuclear magnetic resonance imaging and a preparation method thereof. Background technique [0002] Gastric acid (HCl) is a substance secreted by gastric parietal cells and plays an important role in the digestion and assimilation of food. Its functions are: 1) activate pepsinogen and convert it into activated pepsin. In addition, gastric acid can further provide a suitable acidic catalytic environment for pepsin: 2) once gastric acid flows into the small intestine, it can stimulate the secretion of pancreatic juice, bile and small intestinal juice; 3) decompose the connective tissue fibers and tissues in the food, denature the protein, and easily Absorption; 4) Inhibit and kill pathogens that come with food; 5) Combine with calcium and iron ions to form soluble salts to promote body absorption. A normal gastri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61B5/055
CPCA61B5/055A61B5/4283A61B5/6861A61B2562/12A61B2562/162
Inventor 陈卓徐逸婷夏昕蔡芯琪杨艳霞董倩
Owner HUNAN UNIV
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