Qingkailing tablet and preparation method thereof

A technology of Ling tablet and film formulation, applied in the field of Qingkai Ling tablet and its preparation, can solve problems such as poor drug absorption effect, achieve the effects of improving taste, improving neuroendocrine immune function of animal body, and scavenging free radicals

Inactive Publication Date: 2020-09-15
ZHEJIANG YUANLIJIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a Qingkailing tablet and its preparation method, to solve the problem of slow drug release and poor drug absorption effect of Qingkailing tablet in the prior art

Method used

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Examples

Experimental program
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preparation example Construction

[0030] The present invention proposes a preparation method of Qingkailing tablets, comprising the steps of:

[0031] Step 1, weigh extract a, extract b and extract c, dry and pulverize extract a, extract b and extract c, then mix the ground materials to obtain extract powder;

[0032] Step II, mix and granulate the extract powder, hyodeoxycholic acid, cholic acid, baicalin, dextrin and cornstarch, granulate after drying, then add magnesium stearate and mix evenly, perform coating operation after tableting, Wrap the modified sustained-release coating agent on the periphery of the compressed tablet, and cool it into the warehouse after coating.

[0033] In the step I, the drying temperature is 70°C-90°C, and the drying time is 20min-40min.

Embodiment 1

[0035] A Qingkailing tablet, the raw materials of which include by weight: 40 parts of cholic acid, 30 parts of mother of pearl, 20 parts of hyodeoxycholic acid, 6.5 parts of gardenia, 10 parts of buffalo horn, 6 parts of isatidis, 4 parts of baicalin, 6 parts of honeysuckle, 6 parts of dextrin, 6 parts of corn starch, 6 parts of magnesium stearate, 10 parts of modified slow-release coating agent.

[0036] The modified slow-release coating agent is prepared according to the following process: by weight, 20 parts of α-starch, 45 parts of rice husk powder, 20 parts of chitosan, 3.5 parts of sodium glutamate, 12 parts of donkey-hide gelatin, 6 parts Mix cassava flour, 6 parts of seaweed, 4.5 parts of saccharin, 6 parts of spirulina, 4.5 parts of shellin and 6 parts of soybean lecithin, stir at 500r / min for 25min, and then dry in a freeze dryer at -40°C 30min, then add 19 parts of polylactic acid and mix evenly, stir at 5000r / min for 15min, then add 18 parts of ethanol gel and mix...

Embodiment 2

[0048] A kind of Qingkailing tablet, its raw material comprises by weight: 30 parts of cholic acid, 40 parts of mother-of-pearl, 15 parts of hyodeoxycholic acid, 8 parts of gardenia, 6 parts of buffalo horn, 8 parts of Radix Radix, 2 parts of baicalin, 8 parts of honeysuckle, 3 parts of dextrin, 8 parts of corn starch, 3 parts of magnesium stearate, 15 parts of modified slow-release coating agent.

[0049] The modified slow-release coating agent is prepared according to the following process: 15 parts of α-starch, 50 parts of rice husk powder, 15 parts of chitosan, 5 parts of sodium glutamate, 8 parts of donkey-hide gelatin, 8 parts of Mix tapioca flour, 3 parts of seaweed, 6 parts of saccharoterpenoid, 4 parts of spirulina, 6 parts of husk and 4 parts of soybean lecithin, stir at 650r / min for 20min, and then dry in a freeze dryer at -50°C 20min, then add 24 parts of polylactic acid and mix evenly, stir at 4500r / min for 20min, then add 15 parts of ethanol gel and mix evenly, t...

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PUM

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Abstract

The invention discloses a Qingkailing tablet. The Qingkailing tablet comprises the following raw material sin parts by weight: 30 to 50 parts of cholic acid, 20 to 40 parts of concha margaritifera, 15to 25 parts of hyodeoxycholic acid, 5 to 8 parts of fructus gardeniae, 6 to 14 parts of buffalo horns, 4 to 8 parts of radix isatidis, 2 to 6 parts of baicalin, 4 to 8 parts of honeysuckle flowers, 3to 9 parts of dextrin, 4 to 8 parts of corn starch, 3 to 9 parts of magnesium stearate and 5 to 15 parts of a modified sustained-release coating agent. The invention also provides a preparation method of the Qingkailing tablet. The Qingkailing tablet prepared by the preparation method provided by the invention has the advantages of high stability, good medicine slow-release effects and good medicine absorption effects.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a Qingkailing tablet and a preparation method thereof. Background technique [0002] Qingkailing Granules is derived from Angong Niuhuang Pills, a famous prescription for preventing and treating febrile epidemic diseases in ancient times. It is formulated in strict accordance with the principles of syndrome differentiation and treatment in traditional Chinese medicine, and has undergone hundreds of years of clinical application testing. Its main ingredients are composed of cholic acid, deoxycholic acid, buffalo horn, mother of pearl, baicalin, honeysuckle, mast, and Radix Isatidis. disease. Cholic acid, Scutellaria baicalensis, Scutellaria chinensis, honeysuckle, and Radix Radix have antibacterial and antibacterial effects; Scutellaria baicalensis, honeysuckle, and Radix Radix have antiviral effects, and the antipyretic effect is rapid, long-lasting, and...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K36/82A61K9/22A61K9/36A61K47/18A61K47/36A61K47/34A61K47/46A61P29/00A61P25/20A61P11/04A61P1/02A61P11/00A61P31/16A61K35/748A61K35/618A61K35/32A61K31/685A61K31/575A61K31/7048
CPCA61K9/2059A61K9/282A61K9/2853A61K9/286A61K9/288A61K9/2893A61K31/575A61K31/685A61K31/7048A61K35/32A61K35/618A61K35/748A61K36/02A61K36/195A61K36/315A61K36/355A61K36/744A61K36/82A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P1/02A61P11/00A61P11/04A61P25/20A61P29/00A61P31/16A61K2300/00
Inventor 付泽飞赖阳平陈建伟王贵花陆方舟
Owner ZHEJIANG YUANLIJIAN PHARMA
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