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Temperature-responsive triblock hydrogel copolymer and preparation method thereof

A temperature-responsive, copolymer technology, applied in medical science, bandages, etc., can solve the problems of inability to resist bacterial invasion, increase the risk of infection, and lack of antibacterial properties, and achieve good injectability and postoperative cleaning convenience, excellent biological Compatibility, effect of good self-healing properties

Inactive Publication Date: 2020-09-15
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, after the hydrogel is placed on the wound, the movement of body muscles can easily lead to damage or even rupture of the colloid, which increases the risk of infection, and also destroys the structure of the hydrogel and affects its function.
In addition, the hydrogel itself is not antibacterial and cannot resist the invasion of bacteria, so there is a risk of infection
After long-term use of hydrogel, the hydrogel swells due to its strong water absorption capacity, and it is poorly attached to the wound surface
In addition, the ideal hydrogel applied to burn wounds needs to meet higher requirements: self-repairing dressing damage, with strain resistance; carrying some drugs to prevent wound infection, with antibacterial properties; state can be changed, with long-term fit ; to release a certain drug that promotes wound healing; however, there is currently no hydrogel that can achieve the above characteristics in clinical practice

Method used

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  • Temperature-responsive triblock hydrogel copolymer and preparation method thereof
  • Temperature-responsive triblock hydrogel copolymer and preparation method thereof
  • Temperature-responsive triblock hydrogel copolymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A three-block hydrogel copolymer with temperature response, which is an ABA type three-block network copolymer polymerized by polyethylene glycol monomers and N-isopropylacrylamide monomers, said The copolymer contains mussel biomimetic tissue adhesive groups and silver nanoparticle anchor groups, and its molecular structure is as follows:

[0030]

[0031] The hydrogel copolymer has obvious temperature-sensitive properties (such as figure 1 ), which is in a liquid state at room temperature or below body temperature, and turns into a gel state at body temperature or when it contacts the body surface, which is convenient for its storage and transportation, and is beneficial for surgical use such as spraying or injection.

[0032] The preparation method of the hydrogel refers to the method in "ACS applied materials&interfaces. 2017; 9(11):9221-9225", specifically:

[0033] (1) First, N-isopropylacrylamide monomer and polyethylene glycol monomer are synthesized into co...

experiment example 1

[0038] Construct rat severe burn model, the hydrogel material obtained in embodiment 1 (with the mass ratio of polyethylene glycol monomer and N-isopropylacrylamide monomer 1:3 as example, the number average of polyethylene glycol Molecular weight is 3000) is used for repairing after the burn, discusses embodiment 1 gained hydrogel material for the protective effect that the rat local tissue recovers after the burn and the inhibitory effect of systemic inflammatory response, and its method is as follows:

[0039] Take 40 rats and divide them into 4 groups, control group (Control), model group (Burn), positive control group (Burn+Intrasite Gel), and experimental group (Burn+HydrogelA). All rats were shaved on the back, and carried out general anesthesia with 1% pentobarbital sodium 1mL intraperitoneal injection, taking the area as 30% of the total surface area (TBSA=K*W*0.5, K=0.9, W is the weight of the mouse) as burn area. All rats except the control group were anesthetized ...

experiment example 2

[0045] The hydrogel prepared in "ACS applied materials&interfaces.2017; 9(11):9221-9225" was used in the severe burn model of rats mentioned above, which was recorded as the positive control group 2. By loading CsA, it was compared with the experimental group of the present invention. The results are shown in Table 2:

[0046] Table 2

[0047]

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PUM

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Abstract

The invention provides a temperature-responsive triblock hydrogel copolymer and a preparation method thereof. The hydrogel copolymer is an ABA-type triblock network copolymer formed by polymerizing apolyethylene glycol monomer and an N-isopropyl acrylamide monomer, the copolymer comprises a mussel biomimetic tissue adhesive group and a silver nanoparticle anchoring group, and the number average molecular weight of the polyethylene glycol is 3,000-5,000. The hydrogel copolymer provided by the present invention can be used for rapid healing of burn wounds, has biological tissue adhesion and antibacterial properties, and can carry different drugs according to clinical needs. At the same time, the hydrogel copolymer has temperature-sensitive properties, is convenient to store and transport, and is beneficial for surgical use such as spraying or injection. The molecular structural formula of the hydrogel copolymer is shown in formula (I).

Description

technical field [0001] The invention belongs to the technical field of hydrogel materials, and in particular relates to a temperature-responsive tri-block hydrogel copolymer and a preparation method thereof. Background technique [0002] Burn is a kind of tissue damage caused by various heat sources including hot liquid, high-temperature gas, flame, red-hot metal, chemical substances, etc., and mainly occurs in surface tissues such as skin and mucous membranes. After severe burns, in addition to regional local skin and mucous membrane damage, the following reactions may also occur: increased metabolism, decreased body temperature, excessive water loss, massive loss of protein, and disorders of the endocrine and immune systems. The exposed burn wounds, in addition to causing the body's fluid balance disorder and the destruction of the defense barrier in a short period of time, the wounds that do not heal for a long time will also become a breeding ground for bacterial coloniz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0019A61L26/0061A61L26/0066A61L26/008A61L2300/104A61L2300/252A61L2300/404A61L2300/41A61L2300/412A61L2300/602C08L87/005
Inventor 刘睿奇
Owner WEST CHINA HOSPITAL SICHUAN UNIV