Preparation method of perdeuterated 1, 5-diaminotetrazole
A technology of diaminotetrazole and deuteration, which is applied in the field of synthesis of deuterated energetic materials, can solve the problems of high sensitivity of cyanogen azide and the danger of direct use, and achieve short operation process, safe and controllable operation process, and safe sex high effect
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Embodiment 1
[0016] Place a three-port pressure-resistant device with a volume of 100mL and 0.92g of cyanogen chloride in a high-precision medium-temperature circulating bath at -15°C, seal the device, replace the air in the device with nitrogen for three times, and then pass constant pressure dripping Add 14.3g of anhydrous acetonitrile dropwise into the device through the funnel at a rate of 1mL / min. After the dropwise addition, start stirring at a rate of 50rpm and stir for 15 minutes. After the cyanogen chloride is completely dissolved, slowly add 0.8g of acetonitrile into the device. For sodium nitride, keep the temperature of the solution not higher than -5°C during the addition process. After the addition is complete, seal the reaction device, replace the air in the device with nitrogen, replace three times, raise the temperature to 5°C, and heat the solution for 6 hours. The temperature was lowered to -3°C, followed by suction filtration to obtain filtrate C;
[0017] The filtrate ...
Embodiment 2
[0020] Place a three-port pressure-resistant device with a volume of 100mL and 1.66g of cyanogen chloride in a high-precision medium-temperature circulating bath at -15°C, seal the device, replace the air in the device with nitrogen for three times, and then pass constant pressure dripping Add 27.2g of anhydrous acetonitrile dropwise into the device through the funnel at a rate of 2mL / min. After the dropwise addition, start stirring at a rate of 70rpm and stir for 17 minutes. After the cyanogen chloride is completely dissolved, slowly add 1.7g of acetonitrile into the device. Potassium nitride, keep the solution temperature not higher than -5°C during the addition process, after the addition is complete, seal the reaction device, replace the air in the device with nitrogen, replace three times, raise the temperature to 10°C, keep stirring for 5 hours, and dissolve the solution The temperature was lowered to -3°C, followed by suction filtration to obtain filtrate C;
[0021] Th...
Embodiment 3
[0024] Place a three-port pressure-resistant device with a volume of 200mL and 4.77g of cyanogen bromide in a high-precision medium-temperature circulating bath at -10°C, seal the device, replace the air in the device with nitrogen for three times, and then pass constant pressure dripping Add 84.8g of anhydrous acetonitrile dropwise into the device through the funnel at a rate of 4mL / min. After the dropwise addition, start stirring at a rate of 80rpm and stir for 17 minutes. After the cyanogen bromide is completely dissolved, slowly add 2.2g of acetonitrile into the device. For sodium nitride, keep the temperature of the solution not higher than -5°C during the addition process. After the addition is complete, seal the reaction device, replace the air in the device with nitrogen, replace three times, raise the temperature to 10°C, keep stirring for 5 hours, and dissolve the solution The temperature was lowered to -4°C, followed by suction filtration to obtain filtrate C;
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Abstract
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