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Application of coryfolin to preparation of drug for preventing or treating cochlear hair cell damage

A technology of psoralen, cochlear hair cells, applied in the directions of drug combination, drug delivery, medical formula, etc., to achieve the effect of protecting hearing

Active Publication Date: 2020-10-16
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing auricular point therapy only stimulates points through physical means such as "pressure" and "magnetism", and does not combine effective drug percutaneous absorption for treatment

Method used

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  • Application of coryfolin to preparation of drug for preventing or treating cochlear hair cell damage
  • Application of coryfolin to preparation of drug for preventing or treating cochlear hair cell damage
  • Application of coryfolin to preparation of drug for preventing or treating cochlear hair cell damage

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Evaluation of the effect of psoralen A on preventing and protecting cochlear hair cell damage

[0032]Studies have shown that high-intensity noise exposure or ototoxic drug exposure can cause cochlear hair cell apoptosis, degeneration, necrosis, and central auditory processing dysfunction, and the death of cochlear outer hair cells is the earliest and most important cause of noise-induced cochlear hair cell damage. Pathological changes. The accumulation of reactive oxygen species (ROS) is the cause of hearing loss. Therefore, after the prophylaxis and protection of psoralen A, the MTT cell activity detection, flow cytometry detection and intracellular reactive oxygen species ROS were performed on the cochlear hair cell (HEI-OC1) injury model stimulated by the ototoxic drug acetaminophen. Level detection, in order to verify the ear injury prevention and protection effect of psoralen A.

[0033] 1. Materials:

[0034] Preparation of psoralen A mother solutio...

Embodiment 2

[0055] Embodiment 2: Preparation of psoralen A drug-loaded pellets

[0056] 1. Materials

[0057] The carrier is medical stone pellets with a diameter of about 2 mm. The scientific name is quartz monzonite (purchased from Hebei Hongyao Mineral Products Company). It is a natural silicate mineral that is non-toxic and harmless to organisms. The main chemical composition is Inorganic aluminosilicate, the sphere is hard and the surface contains micropores (see figure 2 shown in A and B), has strong adsorption, and is an ideal framework material for drug-loaded pellets; Opadry (purchased from Shanghai Colorcon Coating Technology Co., Ltd.) is a common drug coating material. It can optimize appearance, improve odor, effectively prevent light and moisture, and increase drug stability.

[0058] 2. Instruments: electronic balance, precision booster electric stirrer, 300ml beaker, fluidized bed (Glatt, Germany).

[0059] 3. Preparation of psoralen A drug-loaded pellets

[0060] (1)...

Embodiment 3

[0076] Embodiment 3: the preparation of psoralen A hydrogel

[0077] 1. Quality composition of psoralen A hydrogel:

[0078] Quality composition of psoralen A hydrogel: final concentration of psoralen A is 0.002%, sodium polyacrylate (AH-105X) 5.4%, aluminum glycolate 0.19%, tartaric acid 0.23%, glycerin 15.77%, polyethylene glycol Alcohol (PEG 400) 4.5%, sodium carboxymethylcellulose (CMC-NA) 0.33%, disodium edetate (EDTA-2NA) 0.25%, polyvinylpyrrolidone (PVPK90) 0.62%, azone 0.6% , the balance is deionized water, and the total amount is 100%.

[0079] 2. Preparation process:

[0080] (1) Instruments: electronic balance, precision booster electric stirrer, 300ml beaker, spatula, mortar.

[0081] (2) Preparation method: Mix 5.4g of sodium polyacrylate, 0.33g of CMC-NA, 0.25g of EDTA-2NA and 0.19g of aluminum glyoxate according to the amount of the formula. PEG400, stir evenly at a low speed (no foaming is preferred), which is the oil phase; dissolve 0.23g tartaric acid in ...

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Abstract

The invention discloses application of coryfolin to preparation of a drug for preventing or treating cochlear hair cell damage. The drug is an auricular point pasting bean for preventing noise-inducedhearing loss; the auricular point pasting bean is coryfolin hydrogel auricular point pasting bean which is prepared by the steps of pasting a coryfolin-carrying mini-pill to coryfolin hydrogel and performing drying l in the shade at the room temperature for 24 h; an effective component of the coryfolin hydrogel auricular point pasting bean is derived from the kidney-tonifying traditional Chinesemedicine coryfolin and is combined with traditional Chinese medicine auricular point treatment means to prepare the auricular point pasting bean, and through pharmacodynamic verification, the preparation has a targeted protection effect on the cochlear hair cell damage caused by multiple reasons, can press and stimulate the auricular point, can stably and effectively realize transdermal absorptionof the drug and protects hearing jointly.

Description

[0001] (1) Technical field [0002] The invention relates to an auricular point sticking bean, which can prevent ear damage caused by recreational noise. [0003] (2) Background technology [0004] Noise-induced hearing loss, also known as noise-induced deafness, is a slow, progressive sensorineural deafness caused by long-term exposure to noise stimulation. Recreational noise injury refers to ear injury caused by unreasonable use of mobile phones, MP3 and other audio equipment with earphones, and being in noisy entertainment places such as KTV and bars. Studies at home and abroad have proved that exposure to recreational noise for a long time and at high volume will cause serious damage to cochlear hair cells. The number of cochlear hair cells in each person is fixed, and they have no ability to regenerate. Once lost, it will cause irreversible damage to the user's hearing. Excessive hearing loss can have a profound impact on us personally and as a society, including physica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/06A61K9/50A61K47/32A61K47/38A61K47/10A61P27/16
CPCA61K31/352A61K9/06A61K9/5047A61K9/0046A61K47/32A61K47/38A61K47/10A61P27/16
Inventor 高建莉沈佳曼丁船贺唯易
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY