Biomimetic electronic skin medical stent material with self-repairing function and preparation method thereof

A scaffold material and self-repair technology, applied in medical science, prosthesis, etc., can solve problems such as poor mechanical properties, uncertain antigen elimination, unsuitable control of degradation rate, etc., to prevent shedding, protect cell shape, and good self-repair performance effect

Inactive Publication Date: 2020-10-27
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it also has problems such as poor mechanical properties, uncertain elimination of antigenicity, and unsuitable control of degradation rate.

Method used

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  • Biomimetic electronic skin medical stent material with self-repairing function and preparation method thereof
  • Biomimetic electronic skin medical stent material with self-repairing function and preparation method thereof
  • Biomimetic electronic skin medical stent material with self-repairing function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Preparation of acidified carbon nanotube dispersion: Accurately weigh 1.0 g of multi-walled carbon nanotubes (MWCNTs), 50.0 g of concentrated H 2 SO 4 (98%), 100 g HNO 3 (65~68%) in a three-necked flask, heated to 50°C, and the reaction time was 15 hours; after the reaction was complete, centrifuged at a gradient speed, and the conditions of the gradient speed centrifugation were: ① centrifuge at 5000 rpm for 60 min, and filter; ② add 100.0 mL Centrifuge ultrapure water at 8000 rpm for 60 min, filter; ③ add 100.0 mL of ultrapure water, centrifuge at 10000 rpm for 60 min, repeat each centrifugation step 3 times, store in freeze-dry; weigh 0.1 g of acidified carbon Nanotube powder, in 200 mL H 2 Sonicate in O for 0.5 h to prepare a 0.05% (m / v) acidified multi-walled carbon nanotube dispersion and store it for future use;

[0040] (2) Preparation of acidified carbon nanotube / PEDOT:PSS composite dispersion: accurately measure 10.0 mL of ultrapure water into a single-...

Embodiment 2

[0045] (1) Preparation of acidified carbon nanotube dispersion: Accurately weigh 3.0 g of multi-walled carbon nanotubes (MWCNTs), 250.0 g of concentrated H 2 SO 4 (98%), 20 g HNO 3 (65~68%) in a three-neck flask, heated to 80°C, and the reaction time was 10 hours; after the reaction was complete, centrifuged at a gradient speed, the conditions were: ① centrifuge at 3000 rpm for 30 min, and filter; ② add 300.0 mL ultrapure water , centrifuge at 6500 rpm for 30 min, filter; ③ add 300.0 mL of ultrapure water, centrifuge at 9000 rpm for 30 min, repeat each centrifugation step 4 times, freeze-dry and store; weigh 0.5 g of acidified carbon nanotubes powder, in 100mL H 2 Supersonicate in O for 1.0 h to prepare a 0.5% (m / v) acidified multi-walled carbon nanotube dispersion, which is stored for subsequent use;

[0046] (2) Preparation of acidified carbon nanotube / PEDOT:PSS composite dispersion: accurately measure 50.0 mL of ultrapure water into a single-necked flask, and accuratel...

Embodiment 3

[0051] (1) Preparation of acidified carbon nanotube dispersion: Accurately weigh 5.0 g of multi-walled carbon nanotubes (MWCNTs), 150.0 g of concentrated H 2 SO 4 (98%), 50 g HNO 3 (65~68%) in a three-neck flask, heated to 100°C, and the reaction time was 5 hours; after the reaction was complete, centrifuged at a gradient speed, the conditions were: ①Centrifuge at 1000 rpm for 10 min, and filter; ②Add 100.0 mL ultrapure water , centrifuge at 5000 rpm for 10 min, filter; ③ add 500.0 mL of ultrapure water, centrifuge at 8000 rpm for 10 min, repeat each centrifugation step 3 times, freeze-dry and store; weigh 1.0 g of acidified carbon nanotubes powder, in 50mL H 2 Ultrasound in O for 2.0 h, prepare a 2.0% (m / v) acidified multi-walled carbon nanotube dispersion, and store it for later use;

[0052] (2) Preparation of acidified carbon nanotube / PEDOT:PSS composite dispersion: accurately measure 25.0 mL of ultrapure water into a single-necked flask, and accurately pipette 5.0 mL...

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PUM

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Abstract

The invention relates to the field of gelatin-based biomedical materials, in particular to a preparation method and application of a bionic electronic skin medical stent with a self-repairing function. The method is characterized in that gelatin extracted from an acellular fetal calfskin dermal matrix with good biological safety is used as a raw material; then, conducting polymer poly (3, 4-ethylenedioxythiophene) with good biocompatibility is used; compounding a polystyrene sulfonate (PEDOT: PSS) solution with self-made acidified carbon nanotubes (H-MWCNTs); the hydrogel stent with a multifunctional three-dimensional network space structure is obtained through crosslinking of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), and the hydrogel is good in biocompatibility and high in mechanical strength, has both self-repairing performance and tissue regeneration inducing repairing performance and can be widely applied to skin wound repairing treatment.

Description

technical field [0001] The invention discloses a preparation method and application of a bionic electronic skin bracket with a self-repairing function, belonging to the field of biomedical materials. Background technique [0002] The skin is the largest organ of the human body, and it is the barrier between the human body and the external environment. The skin barrier refers to the natural defense line composed of the sebum membrane and the stratum corneum on the surface of the skin, which can not only effectively defend against external stimuli, but also lock the moisture in the skin. In real life, skin defects will be caused by burns, trauma, diabetes, chronic ulcers and other reasons, and the human body cannot completely heal any full-thickness skin defects with a diameter greater than 4 cm by itself. [0003] Tissue-engineered skin uses a three-dimensional scaffold as a carrier, and is obtained by planting cells on the scaffold, which can fundamentally solve the problem ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L89/00C08L65/00C08L25/18C08K9/02C08K3/04A61L27/52A61L27/50A61L27/48
CPCC08J3/075C08J3/246A61L27/52A61L27/48A61L27/50C08J2389/00C08J2465/00C08J2425/18C08K2201/011C08K9/02C08K3/041C08L89/00C08L65/00C08L25/18A61L27/26A61L27/443A61L27/60A61L2400/12B29B7/005B29B7/82B29C45/0001B29K2089/00B29K2105/167B29K2507/04B29L2031/7532C08L25/08C08L89/06A61L27/08B29B7/90
Inventor 王学川郑漫辉刘新华岳欧阳侯梦迪王优优
Owner SHAANXI UNIV OF SCI & TECH
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