Coumarin-Tr * ger's base Fe < 3 + > fluorescent probe and preparation method thereof

Abstract

The invention discloses a coumarin-base Fe < 3 + > fluorescent probe which has a structural formula shown in the specification, and is prepared from multiple raw materials such as p-bromoaniline and paraformaldehyde through a multi-step reaction. The synthesis process has the advantages of mild reaction conditions, short reaction time and high yield. The coumarin-base Fe < 3 + > fluorescent probesolution emits green fluorescence and red fluorescence in a solid state, the fluorescence brightness is high, and all compounds have specific recognition capability on Fe < 3 + >, and are low in detection limit, quick in response and good in stability. Tests show that part of the product has a good inhibition effect on cancer cells.

Description

Technical field

[0001] The invention belongs to the field of chemical synthesis, and specifically relates to a class of coumarin- base class Fe 3+ High-brightness fluorescent probe and its preparation method and application. Background technique

[0002] As an essential trace element for the human body, iron is an essential component of hemoglobin and myoglobin, and participates in the transport and exchange of oxygen and carbon dioxide. But excessive iron can cause harm to the human body. Therefore, it is of great significance to establish a fast and efficient detection method. The current methods for detecting iron ions mainly include atomic absorption spectroscopy and high performance liquid chromatography. However, some methods are cumbersome to process, costly, and require large instruments and professional operations. Fluorescence spectroscopy has the advantages of fast response speed, low cost and high sensitivity, and is widely used in the identification of iron ions....

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