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Biodegradable polyurethane for intravascular stents and synthesis method thereof

A biodegradable, polyurethane technology, used in medical science, surgery, etc., can solve problems such as no self-healing function, unusable biomedical use, and lack of biocompatibility.

Active Publication Date: 2020-10-30
梅其勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these polyurethanes are not biodegradable, lack biocompatibility, and cannot be used for biomedical purposes
The above toughened and reinforced polyurethane also does not have self-healing function
Moreover, polyurethane crosslinked with trifunctional monomers or chain extenders does not have reprocessing properties

Method used

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  • Biodegradable polyurethane for intravascular stents and synthesis method thereof
  • Biodegradable polyurethane for intravascular stents and synthesis method thereof
  • Biodegradable polyurethane for intravascular stents and synthesis method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Polycaprolactone diol (M n=3000) at 40°C for 10 h. Polycaprolactone diol, bisphenol A, 4,4',4"triphenylmethane triisocyanate, MDI in a molar ratio of 1:0.1:0.1:1.2 total 500g, 2500mL of chloroform and 0.2g of stannous octoate Sequentially added to the 5L reaction kettle replaced by high-purity nitrogen. The above-mentioned reaction system was heated to 40°C and reacted for 24h. An excessive amount of cold methanol was added to the resulting polymer solution. After separation and drying, the polymeric compound of the present invention was obtained. Biodegradable polyurethane (GPC spectrum as shown in figure 1 Shown), its structural formula is as shown in formula I:

[0043]

[0044] (Formula I), wherein each of m and n is an integer ≥ 1.

[0045] Its number average molecular weight is 50,300, its molecular weight distribution is 2.6, its tensile strength is 42MPa, its elongation at break is 150%, and its impact strength is 680J / m.

[0046] The sample in this examp...

Embodiment 2

[0049] Polylactic acid diol (M n =6000) and dried at 100°C for 3h. The polylactic acid diol, bisphenol AF, 4, 4', 4" triphenylmethane triisocyanate, HDI were added sequentially according to the molar ratio of 8:1:0.2:3, a total of 1000g, 1500mL DMF and 10g of stannous octoate into a 5L reactor replaced by high-purity nitrogen. The above reaction system was heated to 60°C and reacted for 10 hours, and an excessive amount of cold methanol was added to the resulting polymer solution. The biodegradable compound of the present invention was obtained through separation and drying. The polyurethane, its structural formula is shown in following formula II:

[0050]

[0051] (Formula II), wherein each of m and n is an integer ≥ 1.

[0052] Its number average molecular weight is 80,600, its molecular weight distribution is 1.2, its tensile strength is 120MPa, its elongation at break is 380%, and its impact strength is 590J / m.

[0053] The sample in this example was subjected to a ...

Embodiment 3

[0056] Polybutylene carbonate diol (M n =2000) and dried at 50°C for 8h. The polybutylene carbonate diol, bisphenol S, 4,4', 4" triphenylmethane triisocyanate, HDI according to the molar ratio of 8:30:0.1:0.7 total 2000g, 500mL DMF and 50g octanoic acid sulfide Tin is added successively in the 5L reactor that high-purity nitrogen has replaced.The above-mentioned reaction system is heated to 90 ℃, reacts 24h, and in the polymer solution of gained, add excess cold methanol. Obtain the present invention through separation and drying Biodegradable polyurethane, its structural formula is as shown in formula III below:

[0057]

[0058] (Formula III), wherein each of m and n is an integer ≥ 1.

[0059] Its number average molecular weight is 24,600, molecular weight distribution is 5.2, tensile strength is 120 MPa, elongation at break is 20%, and impact strength is 160 J / m.

[0060] The sample in this example was subjected to a damage repair test, and after being completely cut...

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Abstract

The invention provides biodegradable polyurethane for intravascular stents and a synthesis method thereof. The structural formula of the biodegradable polyurethane material is shown in the specification, wherein R2 is a part obtained by removing an isocyanate-terminated group-NCO from diisocyanate, Rt is the part of triisocyanate after the isocyanate-terminated group-NCO is removed, R3 is an aromatic dihydric phenol chain segment, and n is an integer greater than or equal to 1. By introducing the dynamic covalent cross-linking bond, the strength and toughness of the biodegradable polyurethanecan be improved at the same time, the processability of the biodegradable polyurethane is retained, and the biodegradable polyurethane is endowed with a self-repairing function. The method for preparing the biodegradable polyurethane is low in production cost, simple and convenient in process and easy to operate. The biodegradable polyurethane material can be used as a high-performance environment-friendly high polymer material, can be used for preparing a high-performance biodegradable intravascular stent, and has a very high application value.

Description

technical field [0001] The invention belongs to the technical field of polyurethane and its synthesis, and relates to a synthesis method of biodegradable polyurethane for vascular stents, in particular to a synthesis method of dynamic covalent bond cross-linked high-strength, high-toughness self-repairing biodegradable polyurethane , and the biodegradable polyurethane obtained by this method. Background technique [0002] Polyurethane, referred to as polyurethane, has urethane (-NHCOO-) repeating structural units on its main chain. By changing the structure and composition of polyurethane, polyurethane can have a wide range of mechanical properties and processing properties. Due to its excellent elasticity, toughness, wear resistance and weather resistance, polyurethane materials are used to manufacture foam plastics, fibers, elastomers, synthetic leather, coatings, adhesives, pavement materials and medical materials, etc., and are widely used in transportation , Construct...

Claims

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Application Information

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IPC IPC(8): C08G18/76C08G18/73C08G18/66C08G18/44C08G18/42C08G18/32A61L31/14A61L31/06
CPCC08G18/4277C08G18/3215C08G18/664C08G18/6633C08G18/7685C08G18/7671C08G18/73C08G18/724C08G18/3812C08G18/3855C08G18/387C08G18/44C08G18/4238A61L31/06A61L31/148A61L31/14C08G2230/00C08L75/06C08L75/04
Inventor 梅其勇
Owner 梅其勇
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