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Biodegradable polyurethane for vascular stent and synthesis method thereof

A biodegradable and vascular stent technology, which is applied in surgery, medical science, etc., can solve the problems that polyurethane does not have reprocessing performance, does not have self-repair function, and cannot be used for biomedical purposes, and achieves low production cost, easy operation, and improved The effect of strength and toughness

Active Publication Date: 2022-06-03
梅其勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these polyurethanes are not biodegradable, lack biocompatibility, and cannot be used for biomedical purposes
The above toughened and reinforced polyurethane also does not have self-healing function
Moreover, polyurethane crosslinked with trifunctional monomers or chain extenders does not have reprocessing properties

Method used

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  • Biodegradable polyurethane for vascular stent and synthesis method thereof
  • Biodegradable polyurethane for vascular stent and synthesis method thereof
  • Biodegradable polyurethane for vascular stent and synthesis method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Polycaprolactone diol (M n=3000) dried at 40°C for 10h. Polycaprolactone diol, bisphenol A, 4,4',4" triphenylmethane triisocyanate, MDI in a molar ratio of 1:0.1:0.1:1.2, a total of 500g, 2500mL of chloroform and 0.2g of stannous octoate It was added to the 5L reaction kettle replaced by high-purity nitrogen in turn. The above reaction system was heated to 40 ° C and reacted for 24 hours. Excessive cold methanol was added to the obtained polymer solution. Biodegradable polyurethane (GPC spectrum such as figure 1 shown), and its structural formula is shown in the following formula I:

[0043]

[0044] (Formula I), wherein m and n are each an integer >1.

[0045] The number average molecular weight was 50,300, the molecular weight distribution was 2.6, the tensile strength was 42 MPa, the elongation at break was 150%, and the impact strength was 680 J / m.

[0046] The sample in this example was subjected to a damage repair test, and after it was completely cut, it w...

Embodiment 2

[0049] Polylactic acid glycol (M n =6000) dried at 100°C for 3h. The polylactic acid diol, bisphenol AF, 4,4',4" triphenylmethane triisocyanate, HDI were added sequentially according to the molar ratio of 8:1:0.2:3, a total of 1000g, 1500mL of DMF and 10g of stannous octoate. into a 5L reaction kettle replaced by high-purity nitrogen. The above reaction system was heated to 60° C., reacted for 10 hours, and excess cold methanol was added to the obtained polymer solution. The biodegradable described in the present invention was obtained through separation and drying. The polyurethane, its structural formula is shown in the following formula II:

[0050]

[0051] (Formula II), wherein m and n are each an integer >1.

[0052] The number average molecular weight was 80,600, the molecular weight distribution was 1.2, the tensile strength was 120 MPa, the elongation at break was 380%, and the impact strength was 590 J / m.

[0053] The sample in this example was subjected to a d...

Embodiment 3

[0056] Polybutylene carbonate diol (M n = 2000) dried at 50°C for 8h. The polybutylene carbonate diol, bisphenol S, 4,4',4" triphenylmethane triisocyanate, HDI in a molar ratio of 8:30:0.1:0.7, a total of 2000g, 500mL DMF and 50g subcaprylate The tin was added to the 5L reaction kettle replaced by high-purity nitrogen in turn. The above reaction system was heated to 90° C., reacted for 24h, and excess cold methanol was added to the obtained polymer solution. After separation and drying, the method described in the present invention was obtained. Biodegradable polyurethane, its structural formula is shown in the following formula III:

[0057]

[0058] (Formula III), wherein m and n are each an integer >1.

[0059] The number average molecular weight was 24,600, the molecular weight distribution was 5.2, the tensile strength was 120 MPa, the elongation at break was 20%, and the impact strength was 160 J / m.

[0060] The sample in this example was subjected to a damage repa...

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Abstract

The invention provides a biodegradable polyurethane for vascular stents and a synthesis method thereof. The structural formula of the biodegradable polyurethane material is as follows: wherein R2 is the part after the terminal isocyanate group-NCO is removed from diisocyanate; Rt is triisocyanate The part after removing the terminal isocyanate group ‑NCO; R3 is an aromatic dihydric phenol chain segment; n is an integer ≥ 1. The invention can not only improve the strength and toughness of the biodegradable polyurethane by introducing dynamic covalent cross-linking bonds, but also retain its processing performance and endow it with a self-repair function. The provided biodegradable polyurethane method has low production cost, simple process and easy operation. The biodegradable polyurethane material can be used as a high-performance environment-friendly polymer material, and can be used to prepare a high-performance biodegradable vascular stent, and has high application value.

Description

technical field [0001] The invention belongs to the technical field of polyurethane and its synthesis, relates to a method for synthesizing biodegradable polyurethane for vascular stents, and particularly relates to a method for synthesizing a self-repairing biodegradable polyurethane with dynamic covalent bond cross-linking with high strength and high toughness , and the biodegradable polyurethane obtained by this method. Background technique [0002] Polyurethane, referred to as polyurethane, has a urethane (-NHCOO-) repeating structural unit on its main chain. By changing the structure and composition of polyurethane, polyurethane can have a wide range of mechanical properties and processing properties. Due to its excellent elasticity, toughness, wear resistance and weather resistance, polyurethane materials are used to manufacture foamed plastics, fibers, elastomers, synthetic leather, coatings, adhesives, paving materials and medical materials, etc., and are widely use...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/76C08G18/73C08G18/66C08G18/44C08G18/42C08G18/32A61L31/14A61L31/06
CPCC08G18/4277C08G18/3215C08G18/664C08G18/6633C08G18/7685C08G18/7671C08G18/73C08G18/724C08G18/3812C08G18/3855C08G18/387C08G18/44C08G18/4238A61L31/06A61L31/148A61L31/14C08G2230/00C08L75/06C08L75/04
Inventor 梅其勇
Owner 梅其勇
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