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Composition beneficial for promoting bone health and application of composition

A composition and healthy technology, applied in the field of medicine, can solve the problems of unclear mechanism of action, unclear calcium absorption and utilization results, complex composition, etc., and achieve the effects of simple configuration, low cost, and high zinc content

Inactive Publication Date: 2020-11-03
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex composition of the product and the unclear mechanism of action of the preparation obtained by this formula and method, its absorption and utilization of calcium is not clear enough.

Method used

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  • Composition beneficial for promoting bone health and application of composition
  • Composition beneficial for promoting bone health and application of composition
  • Composition beneficial for promoting bone health and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～5 and comparative example 1～2

[0049] 1. Formula components

[0050] Table 1 provides a series of compositions helpful for promoting bone health, which are formed by mixing the components with the mass fractions shown in Table 1. Among them, vitamin D 3 The fine powder for embedding is BASF's Dry Vitamin D3 100GFP.

[0051] The composition formula of table 1 embodiment 1~5, comparative example 1~2

[0052]

[0053] The preparation method is as follows: weighing the above-mentioned components according to the formula amount, mixing and stirring evenly to obtain the composition.

[0054] 2. Formula efficacy evaluation

[0055] Taking the compositions of Examples 3, 4, and 5 as representatives to conduct pharmacological experiments, the compositions prepared in Examples 3, 4, and 5 and Comparative Examples 1, 2 were subjected to animal bone mass testing experiments.

[0056] 1. Rat grouping and modeling

[0057] The 8-week-old SD rats were randomly divided into blank group, model group, comparative exa...

Embodiment 6

[0128] Example 6: Trial Production Sampling of 500kg Material 11.25kg sample was found to have 34 stained flakes, the proportion of stained flakes was about 0.27%.

[0129] After the improvement of tablet stains, samples were taken for crowd evaluation of stains:

[0130] There were 124 participants in the evaluation, and the information is as follows in Table 9:

[0131] Table 9 Background information of color spot evaluators

[0132]

[0133] Test standards for dark spots (ie dark spots) and white spots (ie light spots):

[0134] 1) Whether such black spots on the tablet are acceptable.

[0135] 2) Whether such white spots on the tablet are acceptable.

[0136] Take Example 6 to test from two different angles of dark spots (ie dark spots) and white spots (ie light spots), and ask the evaluators whether they are acceptable. The results show that whether it is dark spots or white spots, the consumer acceptance rate is 79.8%.

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Abstract

The invention discloses a composition beneficial for promoting bone health and an application of the composition. The composition beneficial for promoting bone health consists of the following components in percentage by mass of 39.59%-66.81% of calcium carbonate, 29.59%-60.01% of calcium hydrophosphate, 0.30%-2.59% of zinc citrate and 0.10%-1.01% of vitamin D3 embedded fine powder. All the components in the formula coordinate with one another, the bone mineral density can be effectively increased, expression of RANKL and M-CSFR is reduced, bone tissue is subjected to multi-target-point protection, and the absorption effect is good. Tablets for promoting bone health, prepared from the composition are convenient to carry, smooth and uniform in appearance, free from obvious color spots, pleasant in smell, fine and smooth in mouth feel and excellent in product satisfaction degree.

Description

technical field [0001] The invention belongs to the technical field of medicine. In particular, it relates to a composition and an application thereof for promoting bone health. Background technique [0002] Osteoporosis (osteoporosis) is a systemic bone disease that is prone to fractures due to the decrease in bone density and bone quality and the destruction of bone microstructure due to various reasons. The serious consequence is the occurrence of osteoporosis. Fractures, that is, fractures can occur after minor trauma or daily activities. With the increasing trend of aging, the incidence of osteoporosis is increasing year by year. Osteoporosis is divided into primary and secondary two categories. Primary osteoporosis refers to women's postmenopausal osteoporosis and senile osteoporosis (including men's osteoporosis). Due to aging, female estrogen decreases, and bone remodeling (Remodeling) leads to age-related osteoporosis. Bone loss and metabolic disorders of male s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K33/10A61K33/30A61K33/42A61P19/08A61K31/194A61K31/593
CPCA61K33/10A61K33/42A61K31/194A61K31/593A61K33/30A61K9/2059A61P19/08A61K2300/00
Inventor 罗琥捷罗珍温良明李文治陈媛媛
Owner INFINITUS (CHINA) CO LTD
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