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Polylactic acid dialysis membrane, preparation method thereof and dialyzer

A polylactic acid film and polylactic acid technology, applied in the field of medical equipment, can solve the problems of uneven distribution, poor blood compatibility of polylactic acid, uneven distribution of carboxylated graphene oxide, etc., and achieve good blood compatibility and good purification. effect of blood

Active Publication Date: 2020-11-03
JAFRON BIOMEDICAL
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Problems solved by technology

[0003] In order to solve the problem of the above-mentioned poor blood compatibility of polylactic acid, Portuguese Artur M.Pinto et al. (Biocompatibility of poly(lactic acid) with incorporated graphene-basedmaterials[J].) utilized the method of blending modification to make graphene oxide Doped into the polylactic acid film to improve the blood compatibility of the polylactic acid film, but the blending modification method makes graphene oxide embedded in the polylactic acid film, and there is very little graphene oxide on the surface of the polylactic acid film, resulting in oxidation The active sites on graphene, such as carboxyl and hydroxyl groups, cannot be completely exposed on the surface of the polylactic acid membrane, resulting in limited hemocompatibility on the surface of the polylactic acid membrane.
[0004] Ma Lankun and others (Ma Lankun. Polylactic acid film surface functionalization and blood compatibility research [D]. Tianjin University of Technology doctoral dissertation) used chemical methods to fix carboxylated graphene oxide on polydopamine in a covalent manner The surface of the modified polylactic acid membrane improves the blood compatibility of the polylactic acid membrane, but the prepared modified polylactic acid membrane has the problem of uneven distribution of carboxylated graphene oxide on the surface of the polylactic acid membrane
The uneven distribution of carboxylated graphene oxide will prevent the surface of polylactic acid membrane from being completely covered by carboxylated graphene oxide, resulting in unsatisfactory blood compatibility

Method used

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  • Polylactic acid dialysis membrane, preparation method thereof and dialyzer
  • Polylactic acid dialysis membrane, preparation method thereof and dialyzer
  • Polylactic acid dialysis membrane, preparation method thereof and dialyzer

Examples

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preparation example Construction

[0029] The preparation method of polylactic acid dialysis membrane is:

[0030] Before modifying the polylactic acid film, it is necessary to prepare the catechin compound solution and the carboxylated graphene oxide solution. The preparation steps of the catechin compound solution are: mix 0.1M bis(2-hydroxyethylamino) Tris(hydroxymethyl)methane is mixed with 0.6M sodium chloride to prepare a buffer solution with pH=7, and catechin compounds are dissolved in the buffer solution to prepare a buffer solution with a concentration of 0.5mg / mL~2.0mg / mL Catechin compound solution.

[0031] The preparation steps of carboxylated graphene oxide are: adding concentrated nitric acid and concentrated sulfuric acid to graphene oxide powder, and stirring at 60°C for 12 hours to obtain carboxylated graphene oxide; the mass-volume ratio of graphene oxide, concentrated nitric acid and concentrated sulfuric acid is 1:20:60 (m:v:v).

[0032] The modification step is as follows: soaking the poly...

Embodiment 1

[0056] Example 1 fixes carboxylated graphene oxide to the surface of a polylactic acid film by hydrogen bonding.

[0057] S1, preparation steps of catechin compound solution: mix 0.1M bis(2-hydroxyethylamino)tri(hydroxymethyl)methane with 0.6M NaCl, prepare a buffer solution with pH=7, and epicatechin Gallate was dissolved in the above buffer solution to prepare a 1 mg / mL catechin compound solution;

[0058] Preparation of carboxyl graphene oxide: Weigh 0.5g of dried graphene oxide and put it into a 100mL conical flask; first take 10mL concentrated nitric acid and add it to the conical flask, then take 30mL concentrated sulfuric acid and put it into the conical flask, add With a magnetic stirrer, keep the temperature at 60°C and stir in a water bath for 12 hours to obtain the carboxylated graphene oxide; wash the obtained carboxylated graphene oxide repeatedly with deionized water and centrifuge until the solution is neutral, then ultrasonicate the solution for 2 hours to obta...

Embodiment 2

[0072] Example 2 Carboxylated graphene oxide was immobilized on the surface of polylactic acid film through hydrogen bonding.

[0073] S1. Steps for preparing catechin compound solution: mix 0.1M bis(2-hydroxyethylamino)tris(hydroxymethyl)methane with 0.6M NaCl, prepare a buffer solution with pH=7, and dissolve tannic acid In the above buffer, prepare a 1mg / mL buffer solution;

[0074] Preparation of carboxyl graphene oxide: Weigh 0.5g of dried graphene oxide and put it into a 100mL conical flask; first take 10mL concentrated nitric acid and add it to the conical flask, then take 30mL concentrated sulfuric acid and put it into the conical flask, add With a magnetic stirrer, keep the temperature at 60°C and stir in a water bath for 12 hours to obtain the carboxylated graphene oxide; wash the obtained carboxylated graphene oxide repeatedly with deionized water and centrifuge until the solution is neutral, then ultrasonicate the solution for 2 hours to obtain carboxyl groups oxi...

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Abstract

The invention provides a polylactic acid dialysis membrane, a preparation method thereof and a dialyzer. The polylactic acid dialysis membrane comprises a polylactic acid membrane, a catechinic acid compound and carboxylated graphene oxide, wherein the catechinic acid compound is adhered to the polylactic acid membrane, and the carboxylated graphene oxide is connected with the catechinic acid compound through a hydrogen bond; when the polylactic acid dialysis membrane is prepared, mechanical force is applied to the surface of the polylactic acid dialysis membrane, and the carboxylated grapheneoxide is connected with catechin compounds under the action of the mechanical force. The catechinic acid compound modifies the polylactic acid membrane, so that the surface of the modified polylacticacid membrane has hydroxyl groups, a polylactic acid molecular chain skeleton is not damaged, and the strength of the dialysis membrane is maintained; hydroxyl groups on the surface of the modified polylactic acid film and carboxyl groups of the carboxylated graphene oxide form hydrogen-bond interaction, more carboxyl groups on the carboxylated graphene oxide are reserved, the hydrophilicity of the surface of the modified polylactic acid film is improved, the carboxylated graphene oxide is more uniformly distributed on the polylactic acid film, and the blood compatibility is better.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a polylactic acid dialysis membrane, a preparation method thereof, and a dialyzer. Background technique [0002] The most ideal treatment for patients with end-stage renal disease (ESRD) is kidney transplantation, but there are many patients, the kidney source is seriously insufficient, and the cost of kidney transplantation is high. Therefore, hemodialysis has become the most important means for ESRD patients to prolong their lives. As my country enters an aging society and the number of patients with end-stage renal disease increases, my country's demand for hemodialyzers will be about 500 million by 2023, which means that the hemodialysis membrane in hemodialyzers is a high-demand medical device. At present, the hemodialysis membrane materials widely used in clinical practice are polysulfone and polyethersulfone. The above two materials are petroleum-based materials. The appli...

Claims

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Application Information

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IPC IPC(8): B01D67/00B01D71/40A61M1/16
CPCB01D71/40B01D67/0002A61M1/16B01D2323/12
Inventor 董凡马兰坤祁腾腾黄臣勇
Owner JAFRON BIOMEDICAL
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