Flexible implantable neural photoelectrode and preparation method thereof

Abstract

The invention discloses a flexible implantable neural photoelectrode. The flexible implantable neural photoelectrode comprises a recording electrode layer, a metal interconnection layer and an opticaldevice layer which are sequentially arranged, wherein a plurality of electrode sites are arranged on the recording electrode layer, the metal interconnection layer is used for connecting the electrode sites with the rear end of a neural imaging system, and the optical device layer is used for transmitting laser from the rear end of the neural imaging system to the flexible implantable neural photoelectrode and emitting the laser. The invention further discloses a method for preparing the flexible implantable neural photoelectrode. The flexible implantable neural photoelectrode provided by theinvention is high in integration level, and multi-channel and high-density signal recording can be realized; the size of the part implanted into the brain is small, so that the damage of device implantation to the brain tissue can be reduced; a flexible material is adopted to be matched with the Young modulus of the brain tissue, so that the nerve scar caused in the in-vivo device implantation process can be reduced, and long-term in-vivo stable recording is realized; and accurate stimulation, in-situ recording and cross-brain-region synchronous recording can be realized through photoelectricsignal interconnection.

Description

technical field [0001] The invention relates to the technical field of neuroscience, in particular to a flexible implantable neural photoelectrode and a preparation method thereof. Background technique [0002] The photoelectrode is an electrophysiological device that integrates the functions of light stimulation and electrical activity recording, and is mainly used in conjunction with optogenetics technology. At present, people usually use the combination of optical technology and genetic technology to achieve selective control of cell behavior, and design and prepare devices that can simultaneously realize light regulation and multi-channel electrophysiological recording, that is, neural photoelectrodes. [0003] The simplest neural photoelectrode is the optical fiber electroplating photoelectrode, which electroplates a metal layer on the tapered fiber head, and then encapsulates the metal layer with an insulating layer to only expose the electrical recording point at the ...

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Problems solved by technology

[0005] However, the power consumption of the LED chip implanted in the photoelectrode of the LED light source is relatively high, and the heating of the LED chip will cause damage to the brain tissue, and the size of the LED chip limits the improvement of the integration of the device, making it difficult to achieve multi-channel high-density recording; Waveguide implanted photoelectrodes are mostly processed on a hard silicon substrate. The Young’s modulus of the hard probe on the silicon substrate is very different from that of the brain tissue. Device implantation will cause brain tissue damage and nerve scars, which is difficult to achieve. Long-term in vivo recording, easy to cause damage to the experimental body

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