no n -Application of acyl amino acid ester in the preparation of antitumor drugs

A technology of acyl aminoester and anti-tumor drugs, applied in the field of anti-tumor drugs and drugs, to achieve the effects of high encapsulation efficiency, good biocompatibility and high safety
CN111939147BActive Publication Date: 2022-01-21CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CENT SOUTH UNIV
Publication Date
2022-01-21

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Abstract

The invention belongs to the field of chemotherapeutic drugs and specifically discloses a N n The application of acyl amino acid ester in the preparation of antineoplastic drugs. and discloses a modification with the N n ‑Acyl Amino Acid Esters Antineoplastic Drugs. The present invention found for the first time, N n ‑Acyl amino acid ester has good anticancer activity and anticancer selectivity, can effectively promote the rupture and death of cancer cells, and can avoid the impact on normal cells, with little toxic and side effects. In addition, the anti-cancer active chemotherapeutic component of formula 1 described in the present invention is easy to synthesize and obtain, and the cost is low.
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Description

technical field

[0001] The invention belongs to the field of medicines, in particular to the field of antitumor medicines. Background technique

[0002] Due to lack of selectivity, chemotherapeutic drugs are also highly toxic to normal cells. Classical chemotherapeutic drugs including anticancer drugs, such as cisplatin, doxorubicin, amphotericin B, etc., will all cause systemic toxic and side effects without exception; Although some natural chemotherapeutic drugs such as paclitaxel have good anticancer activity, they have complex structures and many chiral centers, which are mainly obtained by natural component extraction or semi-synthesis. At present, it is still impossible to rely on artificial total synthesis. The source of materials is effective and the cost is high. .

[0003] Nano drug delivery system is a highly respected chemotherapy drug carrier in recent years, such as liposomes (LP), lipid or polymer vesicles, polymer micelles, organic or inorganic nanoparticles...

Claims

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