Carbon microspheres loaded with metal nuclide as well as preparation method and application

Abstract

The invention belongs to the technical field of chemical engineering and medicine, and discloses carbon microspheres loaded with metal nuclide as well as a preparation method and application. The method comprises the following steps: reacting metal ions with organic micromolecules in an aqueous solution to obtain a complex; adsorbing the complex by using carbon microspheres; and carrying out firsttreatment on the adsorbed carbon microspheres. The carbon microspheres loaded with the metal nuclide and prepared by the method can stably exist in the aqueous solution at the temperature lower than180 DEG C and at the pressure lower than 10 MPa, and the dissolution rate of the metal nuclide in the aqueous solution is lower than 0.1%; and the radionuclide release rate is still lower than 0.1% after heat and humidity sterilization at 121 DEG C for 15 minutes, and the safety risk of clinical use of radioactive microsphere products can be remarkably reduced.

Description

technical field [0001] The invention relates to the technical fields of chemical industry and medicine, in particular to carbon microspheres loaded with metal nuclides, a preparation method and application. Background technique [0002] The essence of carbon microspheres is spherical activated carbon, which has the characteristics of high specific surface area, developed pores, uniform particle size, stable physical and chemical properties, and good biocompatibility, and is widely used in food and medicine, energy storage, and environmental protection. To expand the use of carbon microsphere products in chemical industry and medical treatment, metal nuclides are loaded on carbon microspheres. [0003] In the prior art, there are mainly two methods for loading metal nuclides on carbon microspheres, one is to use direct adsorption method to load, and the other is to use tartaric acid, disodium edetate, etc. for complex adsorption. The loading on carbon microspheres or activat...

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Problems solved by technology

[0004] However, in the process of realizing the technical solution of the invention in the embodiment of the present application, the inventors of the present application found that the above-mentioned technology has at least the following technical problems: although the direct adsorption method can be used to prepare radioactive granular products, it is only applicable to barium-131, etc. A small number of nuclides and a small load, moreover, the radionuclides are partially loaded on the surface of the particles, so that further encapsulation is required to prevent the radionuclides from falling off, and the process is more complicated; while the disodium ethylenediaminetetraacetic acid complex adsorption method It can realize the loading of radionuclides such as yttrium-90 on the carbon material, but it usually cannot achieve stable loading, and the dissolution rate of the nuclide of the prepared nuclide-loaded carbon microsphere product increases with the temperature of the aqueous solution. , when the temperature of the aqueous solution is greater than 100°C, the dissolution rate or release rate of the nuclide is greater than 2.0%, and after 15 minutes of damp heat sterilization at 121°C, it cannot meet the index requirements for the radioactive release rate of the radioactive microsphere product. There are greater safety risks in clinical use

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