Dressing for stopping bleeding and preventing cancer recurrence after liver cancer resection

A technology for resection and liver cancer, which is applied in the field of medical materials, can solve the problems of not being able to effectively control bleeding and reduce the amount of bleeding, and achieve the effects of improving hydrophilicity, good slow-release effect, and simple preparation process

Active Publication Date: 2020-11-24
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, surgical methods alone cannot effectively control bleeding during the operation, and the use of highly effective hemostatic materials can significantly reduce the amount of bleeding

Method used

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  • Dressing for stopping bleeding and preventing cancer recurrence after liver cancer resection
  • Dressing for stopping bleeding and preventing cancer recurrence after liver cancer resection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Preparation of verteporfin sustained-release nanomicelles

[0022] Add 8g of lactide, 2g of glycolide, 1g of polyethylene glycol 2000 into the polymerization tube, and then add 0.5g of 0.3% stannous octoate in dichloromethane as a catalyst, heat the polymerization tube to 150°C in vacuum to mix The substance was melted and mixed uniformly, and kept warm for 8h. After natural cooling, dissolve with acetone, precipitate and wash with water to obtain the polymer as the shell material. The hydrophilic test contact angle of the polymer prepared above was 30°, the viscosity was 1.2, and the elongation at break was 4.5%.

[0023] Add 50mg of verteporfin and 200mg of PEG-PE into a flask containing 50ml of methanol, and stir the mixture until completely and uniformly dissolved. Use a low-pressure rotary evaporator, 60°C, 50r / min rotary evaporation to form a thin film, then place the spinner bottle in ice water, vacuum dry to remove excess organic solvent, and form a dry pol...

Embodiment 2

[0027] 1) Preparation of verteporfin sustained-release nanomicelles: This step is the same as in Example 1.

[0028] 2) Preparation of verteporfin sustained-release nanomicelle modified electrospun dressing

[0029] The core liquid of electrospinning is composed of verteporfin sustained-release nano-micelle, chitosan / gelatin / collagen mixture, ultrapure water, the mass content of verteporfin sustained-release nano-micelle is 10%, chitosan The mass content of gelatin / collagen protein mixture is 5%; the shell liquid of electrospinning is made up of chitosan / gelatin / collagen protein mixture, ultrapure water, and the mass content of chitosan / gelatin / collagen protein mixture is 20%; Prepared by the coaxial electrospinning method, wherein the electrostatic high voltage is 50 kV, the receiving distance is 200 mm, and the electrospinning rate is 0.05 ml / min, the verteporfin slow-release nano-micelle modified electrospinning dressing is prepared.

Embodiment 3

[0031] 1) Preparation of verteporfin sustained-release nanomicelles: This step is the same as in Example 1.

[0032] 2) Preparation of verteporfin sustained-release nanomicelle modified electrospun dressing

[0033] The core liquid of electrospinning is composed of verteporfin sustained-release nano-micelle, chitosan / gelatin / collagen mixture, ultrapure water, the mass content of verteporfin sustained-release nano-micelle is 1%, chitosan The mass content of gelatin / collagen protein mixture is 15%; the shell liquid of electrospinning is made up of chitosan / gelatin / collagen protein mixture, ultrapure water, and the mass content of chitosan / gelatin / collagen protein mixture is 25%; Prepared by coaxial electrospinning method, wherein the electrostatic high voltage is 1 kV, the receiving distance is 50 mm, and the electrospinning rate is 0.2 ml / min, the verteporfin slow-release nano-micelle modified electrospinning dressing is prepared.

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Abstract

The invention relates to a dressing for stopping bleeding and preventing cancer recurrence after liver cancer resection. The dressing is characterized in that glycolide and/or lactide are/is used as monomers for polymerization reaction to prepare a polymer; the polymer is used as a shell material, verteporfin is used as a raw material, polyethylene glycol derived phosphatidylethanolamine (PEG-PE)is used as a carrier, and a verteporfin sustained-release nano-micelles are prepared by adopting a thin film dispersion-hydration method; and the dressing for stopping bleeding and preventing cancer recurrence after liver cancer resection is obtained by carrying out coaxial electrostatic spinning on a core solution and a shell solution containing verteporfin sustained-release nano-micelles. The dressing for stopping bleeding and preventing cancer recurrence provided by the invention provides good conditions for stopping bleeding and inhibiting tumor microenvironment after liver cancer resection, realizes release of verteporfin, has enough concentration at an initial stage, and can maintain a long-term slow release effect.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and mainly relates to a dressing for hemostasis after resection of liver cancer and prevention of cancer recurrence, which is applied in the clinical field. Background technique [0002] Bleeding in liver cancer surgery is a major problem in hepatobiliary surgery. On the one hand, the liver has rich blood flow, and it is relatively difficult to stop bleeding after bleeding. On the other hand, bleeding may contribute to tumor recurrence. At present, surgical methods alone cannot effectively control bleeding during surgery, and the use of highly effective hemostatic materials can significantly reduce the amount of bleeding. At present, the most researched hemostatic materials at home and abroad are mainly divided into the following categories: fibrin, gelatin, oxidized cellulose, chitosan, etc. In recent years, electrospinning technology has attracted extensive attention as a simple and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/42A61L15/26A61L15/20A61L15/28A61L15/32
CPCA61L15/44A61L15/42A61L15/26A61L15/20A61L15/28A61L15/325A61L15/32A61L2400/04A61L2300/416A61L2300/602A61L2300/626A61L2300/216A61L2400/12C08L67/04C08L5/08C08L89/00
Inventor 潘子杰陈骅崔翔李建鹏张晗李楠尹雷明陈力
Owner GENERAL HOSPITAL OF PLA
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