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A kind of dressing for hemostasis and cancer recurrence prevention after liver cancer resection

A technology for resection and liver cancer, which is applied in the field of medical materials, can solve the problems of reducing bleeding volume and not being able to effectively control bleeding, and achieves the effects of improving hydrophilicity, good sustained-release effect, and simple preparation process

Active Publication Date: 2022-08-02
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, surgical methods alone cannot effectively control bleeding during the operation, and the use of highly effective hemostatic materials can significantly reduce the amount of bleeding

Method used

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  • A kind of dressing for hemostasis and cancer recurrence prevention after liver cancer resection
  • A kind of dressing for hemostasis and cancer recurrence prevention after liver cancer resection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Preparation of verteporfin sustained-release nanomicelles

[0022] Add 8g lactide, 2g glycolide, 1g polyethylene glycol 2000 to the polymerization tube, then add 0.5g of 0.3% stannous octoate in dichloromethane solution as a catalyst, and heat the polymerization tube to 150°C under vacuum to mix The material is melted and mixed uniformly, and kept for 8h. After natural cooling, it was dissolved in acetone, precipitated and washed with water to obtain a polymer as a shell material. The hydrophilicity test contact angle of the polymer prepared above was 30°, the viscosity was 1.2, and the elongation at break was 4.5%.

[0023] 50 mg of verteporfin and 200 mg of PEG-PE were added to a flask containing 50 ml of methanol, and the mixture was stirred until completely homogeneously dissolved. Use a low-pressure rotary evaporator at 60 °C and 50 r / min to form a thin film, then place the rotary bottle in ice water, vacuum dry to remove excess organic solvent, and form a dry...

Embodiment 2

[0027] 1) Preparation of verteporfin sustained-release nanomicelles: This procedure is the same as that in Example 1.

[0028] 2) Preparation of Verteporfin Sustained Release Nanomicelle Modified Electrospinning Dressing

[0029] The core solution of electrospinning is composed of verteporfin sustained-release nanomicelles, chitosan / gelatin / collagen mixture, ultrapure water, the mass content of verteporfin sustained-release nanomicelles is 10%, chitosan The mass content of gelatin / collagen mixture is 5%; the electrospinning shell liquid is composed of chitosan / gelatin / collagen mixture and ultrapure water, and the mass content of chitosan / gelatin / collagen mixture is 20%; using Prepared by coaxial electrospinning method, wherein the electrostatic high voltage is 50 kV, the receiving distance is 200 mm, and the electrospinning rate is 0.05 ml / min, and the verteporfin sustained-release nanomicelle modified electrospinning dressing is prepared.

Embodiment 3

[0031] 1) Preparation of verteporfin sustained-release nanomicelles: This procedure is the same as that in Example 1.

[0032] 2) Preparation of Verteporfin Sustained Release Nanomicelle Modified Electrospinning Dressing

[0033] The core solution of electrospinning is composed of verteporfin sustained-release nanomicelles, chitosan / gelatin / collagen mixture, ultrapure water, the mass content of verteporfin sustained-release nanomicelles is 1%, chitosan The mass content of gelatin / collagen mixture is 15%; the shell liquid of electrospinning is composed of chitosan / gelatin / collagen mixture and ultrapure water, and the mass content of chitosan / gelatin / collagen mixture is 25%; using Prepared by coaxial electrospinning method, wherein the electrostatic high voltage is 1 kV, the receiving distance is 50 mm, and the electrospinning rate is 0.2 ml / min, and the verteporfin slow-release nanomicelle modified electrospinning dressing is prepared.

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Abstract

The present application relates to a dressing for hemostasis and prevention of cancer recurrence after liver cancer resection. Glycolide and / or lactide are used as monomers for polymerization to prepare polymers, the above polymers are used as shell materials, and verteporfin is used as materials. The raw material, using polyethylene glycol derivatized phosphatidylethanolamine (PEG-PE) as a carrier, adopts a film dispersion-hydration method to prepare verteporfin sustained-release nanomicelles; The core fluid and the shell fluid are coaxially electrospun to obtain hemostatic and anti-cancer recurrence dressings after liver cancer resection. The hemostatic and anti-cancer recurrence dressing of the present application provides good conditions for hemostasis and inhibition of tumor microenvironment after liver resection, and realizes that the release of verteporfin can have a sufficient concentration in the initial stage, and can maintain a long-term sustained release Effect.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and mainly relates to a dressing for hemostasis and cancer recurrence prevention after liver cancer resection applied in the clinical field. Background technique [0002] Bleeding in liver cancer surgery is a major problem in hepatobiliary surgery. On the one hand, liver blood flow is abundant, and it is relatively difficult to stop bleeding after bleeding. On the other hand, bleeding may contribute to tumor recurrence. At present, only relying on surgical methods cannot effectively control bleeding during surgery, and the use of high-efficiency hemostatic materials can significantly reduce the amount of bleeding. At present, the most studied hemostatic materials at home and abroad are mainly divided into the following categories: fibrin, gelatin, oxidized cellulose, chitosan, etc. In recent years, electrospinning technology has attracted extensive attention as a simple and effective ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/42A61L15/26A61L15/20A61L15/28A61L15/32
CPCA61L15/44A61L15/42A61L15/26A61L15/20A61L15/28A61L15/325A61L15/32A61L2400/04A61L2300/416A61L2300/602A61L2300/626A61L2300/216A61L2400/12C08L67/04C08L5/08C08L89/00
Inventor 潘子杰陈骅崔翔李建鹏张晗李楠尹雷明陈力
Owner GENERAL HOSPITAL OF PLA
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