Preparation method of disposable polyethersulfone liquid medicine membrane

A polyethersulfone, disposable technology, applied in chemical instruments and methods, membrane, membrane technology and other directions, can solve the problems of nylon membrane acid and alkali resistance, poor durability, poor firmness, etc., to improve the anti-pollution ability, reduce The effect of increasing the cost of use and the service life

Pending Publication Date: 2020-11-24
山东振富医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the microfiltration membranes produced in the market and used in the filtration of medical clinical infusion terminals mainly include melt-blown polypropylene non-woven fabrics, polyethersulfone microfiltration membranes produced by phase inversion method, nuclear pore membranes, nylon membranes, etc. There are some defects in the membranes. Melt-blown polypropylene non-woven fabrics have long fibers and are easy to fall off. The product is hydrophobic and needs to

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of a disposable polyethersulfone drug liquid membrane provided in this embodiment includes the following steps:

[0024] Step 1. Mix and dissolve polyethersulfone with organic solvent at 40°C-80°C, stir for 6-10 hours, add pore-forming agent, continue stirring for 10-12 hours to fully dissolve, filter insoluble matter and vacuum defoam for 12 -24h to obtain the casting solution, wherein, the polyethersulfone in the casting solution is Japan Sumitomo PES5900p, the molecular weight is 3×105, the weight is 18g, the organic solvent is dimethylformamide, the weight is 55g, and the pore-forming agent is anhydrous Ethanol, parts by weight are 5g;

[0025] Step 2, casting the casting solution on the support body, scraping the film with a scraper, the gap height of the scraper is 0.25mm, the temperature of the scraping film is 30°C, and the relative humidity is 80%, to obtain the primary film;

[0026] Step 3: Leave the nascent membrane in the air for 10-...

Embodiment 2

[0030] The preparation method of a disposable polyethersulfone drug liquid membrane provided in this embodiment includes the following steps:

[0031] Step 1. Mix and dissolve polyethersulfone with organic solvent at 40°C-80°C, stir for 6-10 hours, add pore-forming agent, continue stirring for 10-12 hours to fully dissolve, filter insoluble matter and vacuum defoam for 12 -24h to obtain the casting solution, wherein, the polyethersulfone in the casting solution is Solvay PES3000p, the molecular weight is 2×104, the weight is 16g, the organic solvent is dimethylacetamide, the weight is 50g, and the pore-forming agent is acetone , with a weight of 2g;

[0032] Step 2, casting the casting solution on the support body, scraping the film with a scraper, the gap height of the scraper is 0.12mm, the temperature of the scraping film is 20°C, and the relative humidity is 70%, to obtain the primary film;

[0033] Step 3: Leave the nascent membrane in the air for 10-150s to volatilize t...

Embodiment 3

[0037] The preparation method of a disposable polyethersulfone drug liquid membrane provided in this embodiment includes the following steps:

[0038] Step 1. Mix and dissolve polyethersulfone with organic solvent at 40°C-80°C, stir for 6-10 hours, add pore-forming agent, continue stirring for 10-12 hours to fully dissolve, filter insoluble matter and vacuum defoam for 12 -24h to obtain the casting solution, wherein the polyethersulfone in the casting solution is Japan Sumitomo PES5900p, the molecular weight is 5×105, and the weight is 20g, and the organic solvent is N-methyl-2-pyrrolidone (NMP), and the weight is 60g, Pore ​​former is polyvinylpyrrolidone (PVP), and weight is 10g;

[0039] Step 2, casting the casting solution on the support body, scraping the film with a scraper, the gap height of the scraper is 0.40mm, the temperature of the scraping film is 35°C, and the relative humidity is 90%, to obtain the primary film;

[0040] Step 3: Leave the nascent membrane in th...

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Abstract

The invention discloses a preparation method of a disposable polyethersulfone liquid medicine membrane, belonging to the technical field of biomedical polymer materials. The method disclosed by the invention comprises the following steps of: step 1, mixing and dissolving polyethersulfone with an organic solvent at 40-80 DEG C, adding a pore-forming agent, carrying out sufficient stirring and dissolving, filtering out insoluble substances, and carrying out vacuum defoaming to obtain a membrane casting solution, wherein the membrane casting solution comprises, in parts by weight, 15-20 parts ofpolyethersulfone, 45-60 parts of the organic solvent and 1-10 parts of the pore-forming agent; and step 2, casting the membrane casting solution on a support body, and conducting knifing by using a scraper to obtain a primary membrane. According to the preparation method, hydrophilic bonds can be better grafted to a base membrane of the polyethersulfone micro-filtration membrane, so the hydrophilicity of the polyethersulfone membrane is greatly improved, and the flux of liquid is improved; and due to the existence of charges, the anti-pollution capability of the filtration membrane is improved, the service life of the filtration membrane is prolonged, use cost is reduced, and good economic benefits are obtained.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, in particular to a preparation method of a disposable polyethersulfone liquid membrane. Background technique [0002] Infusion therapy can supplement the nutrients, water, electrolytes, etc. necessary for the human body, and plays a very important role in clinical treatment. However, ordinary infusion sets can only filter out particles with a diameter of more than 20 microns in the liquid medicine, and have no interception effect on particles with a diameter of 0.2 microns to 10 microns. The insoluble particles in the drug are very harmful to the human body, may cause blood vessel injury, and are prone to thrombosis, fat embolism, air embolism, etc., and even form thrombophlebitis, which can block microcirculation and cause different degrees of necrosis or necrosis of human tissues or organs. damage. Therefore, the research on filter membranes in medical liquid filters, esp...

Claims

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Application Information

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IPC IPC(8): B01D71/68B01D69/10B01D67/00B01D61/14
CPCB01D71/68B01D69/10B01D67/0011B01D67/0013B01D61/147B01D2323/38B01D2323/02B01D2325/14B01D2325/36
Inventor 张靖华董克兰朱宸颐刘彤
Owner 山东振富医疗科技股份有限公司
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