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Dendritic macromolecular quaternary ammonium salt compound, preparation method and application thereof

A technology of quaternary ammonium salts and macromolecules, applied in botany equipment and methods, chemical instruments and methods, applications, etc., can solve the problems of poor biocidal properties and low penetration, and achieve low cost, easy operation, and low cost. cytotoxic effect

Active Publication Date: 2020-12-15
惠州卫生职业技术学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Larger molecules tend to be less permeable to cell membranes and therefore less biocidal

Method used

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  • Dendritic macromolecular quaternary ammonium salt compound, preparation method and application thereof
  • Dendritic macromolecular quaternary ammonium salt compound, preparation method and application thereof
  • Dendritic macromolecular quaternary ammonium salt compound, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Embodiment 1: the synthesis of the dendrimer surface quaternary ammonium compound of terminal amino group

[0050] 4.76 g of amino-terminated dendrimers G1.0 (NH 2 ) 3 (1equiv, 10mmol) was dissolved in 500mL of anhydrous toluene solution, under ice bath conditions, 3.30g of 2-chloroethyl isocyanate (1.02equiv, 30.6mmol) was added dropwise, and the reaction was stirred 12 hours. Then add 7.67g of N,N-dimethyldodecylamine (1.2equiv, 36mmol), 100mL of N,N-dimethylacetamide, and 100mL of toluene, slowly heat to 80°C, and react at constant temperature for 72 hours, then The solution was concentrated to about 100 mL, and the concentrate was precipitated in acetone. The mixture was filtered and dried in vacuo at 60 °C to obtain a yellow solid material (70% yield).

[0051] IR(KBr,cm -1 ): C-H saturated 2930.4cm -1 ,C=O 1639.9cm -1 ,N-H bend1562.3cm -1 , and N-H stretch 3297.9cm -1 . 1 H NMR (CDCl 3 , δ / ppm): 0.89, 1.25-1.73, 1.82-1.87, 2.54, 3.20, 3.36, 3.51, 3.67, 3...

Embodiment 2

[0052] Embodiment 2: the synthesis of the dendrimer surface quaternary ammonium salt functional compound of terminal acrylate group

[0053] Add 6.55g of acrylate-terminated dendrimer G1.0(acrylate)8 (5.26mmol), 4.43g of diethanolamine (42.2mmol) and 9.49g of methanol into a 100mL three-necked flask in sequence, and stir at 25°C The reaction was carried out for 24 hours. After the reaction, the methanol was distilled off under reduced pressure to obtain 11.0 g (5.28 mmol) of G1.0(OH)16 as a colorless viscous product with a purity of 94.6%.

[0054] Weigh 6.25g (3.00mmol) G1.0(OH)16 into a 100mL three-neck round bottom flask, add 10mL of chloroform, stir to dissolve, slowly add SOCl 2 The acid-binding agent pyridine of the amount of equal substance, then add dropwise 6.55g (0.055mol) SOCl 2 After the dropwise addition was completed, the oil bath was heated to raise the temperature, magnetically stirred at 85° C., and refluxed for 6 hours. After the reaction is over, wait for ...

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PUM

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Abstract

The invention discloses a dendritic macromolecular quaternary ammonium salt compound, a preparation method and application thereof. The quaternary ammonium salt compound comprises amino-terminated andacrylate-terminated dendritic macromolecular quaternary ammonium salt compounds. The dendritic macromolecular quaternary ammonium salt compound disclosed by the invention has good surface activity and bacteriostatic activity.

Description

technical field [0001] The invention relates to the technical field of antibacterial compounds, in particular to a dendritic macromolecule quaternary ammonium salt compound and a preparation method and application thereof. Background technique [0002] Quaternary ammonium salt has been used as a fungicide for nearly a hundred years. Due to its low concentration, low side effect, colorless, odorless, low toxicity and safety, it is widely used as a sterilizing agent for surgical operations and medical equipment, and industrial circulating water treatment. Bactericides and algaecides, cleaning and disinfecting agents for household personal, public health and hard surfaces, cleaning and disinfecting agents for food processing equipment, used to prepare laundry detergents, hand sanitizers and other cleaning products with bactericidal functions. [0003] At present, monovalent and divalent quaternary ammonium fungicides are widely used in the fields of hygiene and biomedicine. It...

Claims

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Application Information

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IPC IPC(8): C08G83/00B01F17/18A01N33/12A01P1/00A01P3/00C09K23/18
CPCC08G83/004C08G83/003A01N33/12C09K23/16Y02A50/30
Inventor 吁诚铭
Owner 惠州卫生职业技术学院
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