Preparation technology of moxifloxacin hydrochloride sodium chloride injection

Abstract

The present invention belongs to the technical field of preparation technologies of moxifloxacin hydrochloride sodium chloride injections and particularly relates to a preparation technology of a moxifloxacin hydrochloride sodium chloride injection. The preparation technology comprises the following steps: S1, adding sodium hydroxide powder into a sterilized and disinfected stirring tank, then adding 50% by volume of water for injection into the stirring tank, conducting full stirring to fully dissolve the sodium hydroxide powder to form a uniform solution; and S2, raising a temperature in thestirring tank to 90 DEG C, then adding moxifloxacin hydrochloride, and conducting uniform stirring. The preparation technology can accelerate filtration of the solution containing activated carbon powder, thus saves filtration time, improves filtration efficiency, can extract out the solution adsorbed inside the medicinal activated carbon powder and thus improves a generation rate of the solution; and meanwhile, a coarse sieve plate and a fine sieve plate are convenient to clean, the coarse sieve plate and the fine sieve plate can be beaten through a beating mechanism while cleaning is conducted, particles clamped in pores of the coarse sieve plate and the fine sieve plate are vibrated out, and the cleaning is more thorough.

Description

technical field [0001] The invention belongs to the technical field of preparation technology of moxifloxacin hydrochloride sodium chloride injection, in particular to a preparation technology of moxifloxacin hydrochloride sodium chloride injection. Background technique [0002] Moxifloxacin hydrochloride is a new broad-spectrum high-efficiency fourth-generation fluoroquinolone antibacterial drug. In 2005, Moxifloxacin hydrochloride sodium chloride injection was launched in China with the trade name: Baifule. From the perspective of chemical structure, the 7th substituent group of moxifloxacin is a diazabicycle, which can reduce drug resistance caused by active efflux of microorganisms (the main mechanism of cross-resistance to quinolones), and ensure its drug resistance Low advantage, the introduction of a methoxy group at the 8th position enables this product to enhance the antibacterial activity against Gram-positive bacteria, atypical pathogenic bacteria and anaerobic ba...

AI Technical Summary

Problems solved by technology

[0005] In order to make up for the shortcomings of the existing technology, solve the problem that the solution remains in the pores of the activated carbon and cannot come out, and the solution will also be adsorbed between the activated carbon particles, resulting in a low output rate o...

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