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Preparation technology of moxifloxacin hydrochloride sodium chloride injection

A technology for sodium chloride injection and moxifloxacin hydrochloride, which is applied in medical preparations containing active ingredients, chemical instruments and methods, and devices for making medicines into special physical or taking forms, etc., which can solve the problem of screen cleaning. Inconvenience, residual activated carbon particles, low solution yield and other problems, to achieve the effect of saving filtration time, efficient cleaning, and improving filtration efficiency

Active Publication Date: 2021-01-05
HUAXIASHENGSHENG PHARMA BEIJING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to make up for the shortcomings of the existing technology, solve the problem that the solution remains in the pores of the activated carbon and cannot come out, and the solution will also be adsorbed between the activated carbon particles, resulting in a low output rate of the solution, and there will still be some activated carbon after filtration. Particles remain in the pores of the screen, which makes the cleaning of the screen inconvenient. A preparation process for moxifloxacin hydrochloride and sodium chloride injection proposed by the present invention

Method used

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  • Preparation technology of moxifloxacin hydrochloride sodium chloride injection
  • Preparation technology of moxifloxacin hydrochloride sodium chloride injection
  • Preparation technology of moxifloxacin hydrochloride sodium chloride injection

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Embodiment approach

[0043] As an embodiment of the present invention, the clamping mechanism includes a sliding groove 19, an insertion rod 24, a cylinder 36 and a push plate 37; one end of the cylinder 36 is fixedly installed on the outer wall of the fixed frame 16; A push plate 37 is provided inside the cylindrical barrel 36; the side of the push plate 37 close to the fixed frame 16 is fixedly connected with the outer wall of the fixed frame 16 through a spring, and the side of the push plate 37 far away from the fixed frame 16 is connected with the insertion rod. One end of 24 is fixedly connected; The free end of described insertion rod 24 is inserted in the draw-in groove 22 of filter case 1 inner wall; The top of described push plate 37 is connected with the bottom end of push rod 18; The bottom end of described push rod 18 Located in the sliding groove 19 on the top edge of the cylinder 36; the top end of the push rod 18 stretches out from the top edge of the cylinder 36; during work, when ...

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Abstract

The present invention belongs to the technical field of preparation technologies of moxifloxacin hydrochloride sodium chloride injections and particularly relates to a preparation technology of a moxifloxacin hydrochloride sodium chloride injection. The preparation technology comprises the following steps: S1, adding sodium hydroxide powder into a sterilized and disinfected stirring tank, then adding 50% by volume of water for injection into the stirring tank, conducting full stirring to fully dissolve the sodium hydroxide powder to form a uniform solution; and S2, raising a temperature in thestirring tank to 90 DEG C, then adding moxifloxacin hydrochloride, and conducting uniform stirring. The preparation technology can accelerate filtration of the solution containing activated carbon powder, thus saves filtration time, improves filtration efficiency, can extract out the solution adsorbed inside the medicinal activated carbon powder and thus improves a generation rate of the solution; and meanwhile, a coarse sieve plate and a fine sieve plate are convenient to clean, the coarse sieve plate and the fine sieve plate can be beaten through a beating mechanism while cleaning is conducted, particles clamped in pores of the coarse sieve plate and the fine sieve plate are vibrated out, and the cleaning is more thorough.

Description

technical field [0001] The invention belongs to the technical field of preparation technology of moxifloxacin hydrochloride sodium chloride injection, in particular to a preparation technology of moxifloxacin hydrochloride sodium chloride injection. Background technique [0002] Moxifloxacin hydrochloride is a new broad-spectrum high-efficiency fourth-generation fluoroquinolone antibacterial drug. In 2005, Moxifloxacin hydrochloride sodium chloride injection was launched in China with the trade name: Baifule. From the perspective of chemical structure, the 7th substituent group of moxifloxacin is a diazabicycle, which can reduce drug resistance caused by active efflux of microorganisms (the main mechanism of cross-resistance to quinolones), and ensure its drug resistance Low advantage, the introduction of a methoxy group at the 8th position enables this product to enhance the antibacterial activity against Gram-positive bacteria, atypical pathogenic bacteria and anaerobic ba...

Claims

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Application Information

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IPC IPC(8): A61J3/00A61K9/00A61K9/08A61K31/4709A61K47/02A61P31/04B01D33/03B01D33/42B01D33/50
CPCA61J3/00A61K31/4709A61K9/08A61K9/0019A61K47/02A61P31/04B01D33/0346B01D33/42B01D33/50A61J2200/42A61J2200/44
Inventor 龚文卿
Owner HUAXIASHENGSHENG PHARMA BEIJING CO LTD
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