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Aperture gradient porous scaffold and minimal curved surface structure unit for same

A curved surface structure and gradient porous technology, applied in the field of biomedical implant materials, can solve the problems of shortened scaffold life, small surface area, unfavorable cell adhesion, etc., to improve biological performance, accelerate tissue regeneration, and improve biocompatibility Effect

Active Publication Date: 2021-01-22
北京科技大学广州新材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the one hand, the porous scaffold with lattice structure tends to generate stress concentration at the intersection of the rods of the lattice structure, which makes the scaffold fail prematurely under the action of periodic loads and greatly shortens the service life of the scaffold; on the other hand, the porous scaffold with lattice structure The small surface area of ​​the porous scaffold is not conducive to cell adhesion

Method used

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  • Aperture gradient porous scaffold and minimal curved surface structure unit for same
  • Aperture gradient porous scaffold and minimal curved surface structure unit for same
  • Aperture gradient porous scaffold and minimal curved surface structure unit for same

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preparation example Construction

[0092] The invention also discloses a method for preparing a porous scaffold with gradient pore size. The preparation method specifically includes the following steps:

[0093] S1, Constructing the structure expression: According to the required structure and performance characteristics of the implant, determine the shape and size parameters of the scaffold, as well as the type, porosity, and size range of the structural units with minimal curved surfaces that need to be selected. Expressions for porous scaffolds with gradient pore sizes;

[0094] S2, constructing the gradient structure: input the expression of the pore-diameter gradient porous scaffold into MATHEMATICA software for visualization processing, and obtain and export the 3D model of the pore-diameter gradient porous scaffold structure based on the minimal surface;

[0095] S3, through the rapid prototyping auxiliary software Materialize Magics, the model of the pore-diameter gradient porous scaffold is layered and...

Embodiment 1

[0103] A pore size gradient porous scaffold based on the Gyroid surface structure unit, the scaffold structure is a columnar porous structure with a size of The porosity is 60%, including the inner scaffold structure 1 and the outer scaffold structure 2; the inner scaffold structure 1 has a larger pore size, which is conducive to the transportation of nutrients, promotes cell proliferation and differentiation, and accelerates tissue regeneration; the outer layer The pore size of the scaffold structure 2 is small, which is conducive to cell adhesion. Specifically, the inner support structure 1 is composed of multiple Gyroid surface structural units with a porosity of 60% and a structural unit size of 2mm. The Gyroid surface structural unit is expressed by the implicit function expression The control is obtained; the outer support structure 2 is composed of multiple Gyroid surface structural units with a porosity of 60% and a structural unit size of 1mm. The Gyroid surface str...

Embodiment 4

[0117] A pore size gradient porous scaffold based on Primitive curved surface structural units, the pore size gradient porous scaffold is a columnar porous structure with a size of The porosity is 50%, including the inner scaffold structure 1 and the outer scaffold structure 2; the inner scaffold structure 1 has a larger pore size, which is conducive to the transportation of nutrients, promotes cell proliferation and differentiation, and accelerates tissue regeneration; the outer layer The pore size of the scaffold structure 2 is small, which is conducive to cell adhesion. Specifically, the inner support structure 1 is composed of a plurality of Primitive surface structural units with a porosity of 50% and a structural unit size of 2mm. The Primitive surface structural unit is expressed by an implicit function According to the control, the outer support structure 2 is composed of multiple Primitive surface structural units with a porosity of 50% and a structural unit size of...

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Abstract

The invention provides an aperture gradient porous scaffold and a minimal curved surface structure for the same. The minimal curved surface structure unit is a Gyroid curved surface structure unit, aPrimitive curved surface structure unit, a Diamond curved surface structure unit or an I-WP curved surface structure unit, and the Gyroid curved surface structure unit, the Primitive curved surface structure unit, the Diamond curved surface structure unit and the I-WP curved surface structure unit are respectively controlled by implicit function expressions. The pore diameters of the Gyroid, Primitive, Diamond and I-WP curved surface structure units are 200-1000 [mu]m, the porosity of the Gyroid, Primitive, Diamond and I-WP curved surface structure units is 10-90%, and the lengths a, b and c of the Gyroid, Primitive, Diamond and I-WP curved surface structure units in the x, y and z directions are 0.5-2 mm. The bionic scaffold with the pore structure and function similar to those of the natural bone is obtained based on the minimal curved surface structure unit.

Description

technical field [0001] The invention relates to the technical field of biomedical implant materials, in particular to a porous scaffold with gradient pore size and a minimally curved surface structure used therefor. Background technique [0002] Porous titanium and titanium alloys have low elastic modulus, high specific strength, excellent corrosion resistance and good biocompatibility, and are widely used in the field of bone repair. However, the mechanical and biological properties of the currently prepared porous titanium alloy bone scaffolds are still not well matched with the properties of human bone tissue. There is insufficient matching between strength and elastic modulus, and the scaffold structure is not conducive to cell adhesion, proliferation and differentiation. And other issues. Therefore, one of the development directions of porous titanium scaffolds is to develop a new type of porous scaffold, which has a pore size distribution similar to that of human bone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82
CPCA61F2/82
Inventor 路新侯辰锦徐伟于爱华何新波潘宇张策
Owner 北京科技大学广州新材料研究院
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